Prof. Jacob George
The Department
of Cardiology
Tel Aviv
University, Israel
E-mail: jgeorge@bezeqint.net
Qualifications
1998 Internal
Medicine Residency (passage of phase B exams in 1997, Cum Laude)
1989 M.D., Technion
Medical School, Haifa, Cum Laude
1986 B.Sc., Technion
Medical School,
Haifa
Publications
(Selected)
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Y. Beigel, J.
George, L. Leibovici, A. Mattityahu, S. Sclarovsky, L. Blieden. Coronary risk
factors in children of parents with premature coronary heart disease. Acta
Pediatrica 82: 162-165, 1993.
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Y. Levy, J.
George, Y. Shoenfeld. The occurrence of thromboembolic events following
airplane flights-’the economy class syndrome’. Isr J Med Sci 331:
621-23, 1995.
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L. Leibovitch,
J. George, Y. Levy, R. Bakimer, Y. Shoenfeld. Anti actin antibodies
determination in sera from patients with autoimmune, liver diseases and
patients with carcinomas by ELISA assay. Immunology Letters 48:
129-132, 1995.
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Y. Levy Y, J.
George, M. Hojnik, M. Ehrenfeld, M. Lorber, S. Bombaridieri, Y.
Shoenfeld. Comparison of clinical and laboratory parameters in
patients with SLE between Israelis versus Europeans. Isr J Med Sci 32:
100-104, 1996.
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G.
Zandman-Goddard, J. George, Y. Levy, M. Blank, S. Slavin, Y. Shoenfeld.
Modulation of experimental systemic lupus erythematosus with linomide. Lupus.
5; 328-333, 1996.
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G.
Zandman-Goddard, J. George, V. Barak, M. Blank, Y. Levy, Y.
Shoenfeld. The effects of early and late administration of M20 IL-1
inhibitor on the manifestations of experimental systemic lupus erythematosus.
Immunology Letters. 53; 77-82, 1996.
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M.
Damianovich, B. Gilburd, J. George, N. Del Papa, A. Afek, I. Goldberg, Y.
Kopolovic, D. Roth, G. Barkai, PL Meroni, Y. Shoenfeld. Pathogenic role of
antiendothelial cell antibodies (AECA) in vasculitis: an idiotypic experimental
model. The Journal of Immunology. 156; 4946-4951, 1996.
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Y. Levy Y, L.
Ziporen, B. Gilburd, J. George, S. Polac-Charcon, H. Amital, J. Cledes, P.
Youinou, Y. Shoenfeld.Membraneous nephropathy in primary antiphospholipid
syndrome; description of a case and induction of renal injury in SCID
mice.Human Antibodies Hybridomas. 7 91-96, 1996.
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A. Livneh,
JPH. Drenth, IS. Klasen, P. Langevitz, J. George, D. Shelton, DL.
Gumucio, E. Pras, DL. Kastner, M. Pras, JWM. van-der Meer. Familial
mediterranean fever and hyperglobulinemia D syndrome: Two diseases with
distinct clinical, serological and genetic features. Journal of Rheumatology.
24; 1558-1563, 1997.
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J. George, M.
Blank, M. Hojnic, E. Bar-Meir, T. Koike, E. Matsuura, M. Lorber, M. Aviram, Y.
Shoenfeld. Oxidized low density lipoprotein (oxLDL) but not LDL aggravates the
manifestations of antiphospholipid syndrome (APS). Clinical and Experimental
Immunology. 108; 227-233, 1997.
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J. George, M.
Blank, B. Gilburd, M. Hojnik, B. Shenkman, I. Tamarin, D. Varon, E. Matsuura,
T. Koike, Y. Shoenfeld. Immunologic characterization and functional properties
of murine antibodies raised against deleted mutants of human beta 2 glycoprotein
I.International Immunology. 9; 913-921, 1997.
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J. George, B.
Gilburd, Y. Levy, A. Afek, M. Damianovich, A. Doria, S Todesco, Y. Shoenfeld.
“Autoantibody dominance” pattern following idiotypic manipulation of naive mice
with different anti-U1RNP antibodies. Pathobiology. 65; 204-209, 1997.
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Y. Levy Y, J.
George, L. Ziporen, J. Cledes, H. Amital, Y. Bar-dayan, A. Afek, P. Youinou, Y.
Shoenfeld.
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Massive
proteinuria as a main manifestation of primary antiphsopholipid syndrome.
Pathobiology. 66: 49-52, 1998.
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J. George, A. Afek,
B. Gilburd, Y. Levy, M. Blank, J. Kopolovic, D. Harats, Y.
Shoenfeld.Atherosclerosis is accelerated in low-density receptor knockout mice
by immunization with anticardiolipin antibodies Lupus. 6: 723-729, 1997.
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J. George, M.
Blank, Y. Levy, PL. Meroni, M. Damianovitch, A. Tincani, Y. Shoenfeld.
Differential effects of anti-b2 glycoprotein I antibodies on endothelial cells
and on the manifestations of experimental antiphospholipid syndrome.
Circulation. 97: 900-906, 1998.
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M. Blank, J.
George, P. Fishman, Y Levy, V Toder, S Savion, Y, Shoenfeld. Ciprofloxacin
immunomodulation of experimental antiphospholipid syndrome associated with
elevation of IL-3 and GM-CSF expression. Arthritis and Rheumatism 41:
224-232, 1998.
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Y Levy, B
Gilburd, J George, M Damianovich, M Blank, N Del-Papa, PL Meroni, P
Youinou, Y Shoenfeld. Monoclonal murine antiendothelial cell antibodies
(AECA)-characteristics and binding properties.International Immunology. 10:
861-868, 1998.
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M Galleazzi, F
Bellisai, GD Sebastiani, G Morozzi, R Marcolongo, F Houssiau, R Cervera, Y
Levy, J. George, Y Sherer, Y Shoenfeld. Association of 16/6 and SA1
anti-DNA idiotypes with anticardiolipin antibodies and clinical manifestations
in a large cohort of SLE patients. European Concerted Action on the
Immunogenetics of SLE. Clin Exp Rheumatology. 16: 717-720, 1998.
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J. George, A.
Afek, B. Gilburd, Y. Levy, H. Levkovitz, A Shaish, I. Goldberg, J. Kopolovic,
G. Wick, Y. Shoenfeld, D. Harats. Hyperimmunization of ApoE deficient mice with
homologous malondialdehyde low-density lipoprotein suppresses early
atherogenesis. Atherosclerosis. 138: 147-152, 1998.
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M. Blank, J. George, V. Barak,
A. Tincani, T. Koike, Y. Shoenfeld. Oral tolerance to low dose b2GPI:
immunomodulation experimental antiphospholipid syndrome. The Journal of
Immunology. 161: 5303-5312, 1998.
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J. George,
A. Afek, B. Gilburd, Y. Levy, A. Aron-Maor, A. Shaish, H. Levkovitz, M. Blank,
D. Harats, Y. Shoenfeld. Induction of early atherosclerosis in LDL receptor
deficient mice by immunization with beta 2 glycoprotein I. Circulation. 98:
1108-1115, 1998.
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J. George,
M. Pantaik, E. Bakshi, Y. Levy. A. Ben David, A. Ahmed, JB Peter, Y. Shoenfeld.
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Seropositivity
for Hantavirus in Isreali patients with end stage renal failure. Viral Immunology.
11: 103-108, 1998.
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J. George, B.
Gilburd, M. Hojnik, Y. Levy, P. Langevitz, E. Matsuura, T. Koike, Y. Shoenfeld.
Target recognition of b2-glycoprotein I (b2GPI)-dependent
anticardiolipin antibodies: Evidence for involvement of the IV domain of b2GPI
in antibody binding. The Journal of Immunology 32: 116-125, 1998.
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J. George, B.
Gilburd, P Langevitz, Y. Levy, D. Harats, Y. Shoenfeld. b2-glycoprotein
I containing immune complexes: association with thrombocytopenia and
lipoprotein (a) levels.Lupus. 8: 116-120, 1999.
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J. George, Y.
Shoenfeld, A. Afek, B. Gilburd, P. Keren, A. Shaish, Y. Kopolovic, D. Harats.
Enhanced fatty streak formation C57BL/6J mice by immunization with heat shock
protein 65. Arterioscler Thromb Vasc Biol. 19: 505-510, 1999.
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A. Afek, J.
George, Y. Shoenfeld, B. Gilburd, Y. Levy, P. Keren, A. Shaish, D. Harats.
Enhanced Atherosclerosis in ApoE deficient mice by immunization with b2-glycoprotein
I Pathobiology. 67: 19-25, 1999.
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J. George, D.
Harats, B. Gilburd, Y. Levy, P. Langevitz, Y. Shoenfeld. Atherosclerosis
related markers in systemic lupus erythematosus patients: the role of humoral
immunity in enhanced atherogenesis. Lupus. 8: 220-226, 1999.
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J. George, D.
Harats, B. Gilburd, A. Afek, Y. Levy, J. Schneiderman, I. Barshack, J.
Kopolovic, Y. Shoenfeld. Immunolocalization of b2-glycoprotein
I to human atherosclerotic plaques: potential implications for lesion
formation. Circulation. 99; 2227-2230, 1999.
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A Shaish, J.
George, B Gilburd, P Keren, H Levkovitz, D Harats. Dietary b-carotene
and a-tocopherol combination does not inhibit atherogenesis in an apoE
deficient mouse model. Arterioscler Thromb Vasc Biol. 19:1470-1475, 1999.
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N. Zurgil, Y.
Levy, K. Deutch, B. Gilburd, J. George, D. Harats, Y. Shoenfeld.
Reactivity of peripheral blood lymphocytes (PBL) to oxidized LDL: a novel
system to estimate atherosclerosis employing the cell scan.Clinical Cardiology.
22; 55-62, 1999.
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Y. Levy, Y.
Sherer, J. George, P. Langevitz, A. Ahmed, Y. Bar-dayan, F.
Fabrizzi, J. Terryberry, JB Peter, Y. Shoenfeld. Serologic and clinical
response to treatment of systemic vasculitis associated autoimmune disease with
intravenous immunoglobulin. Int Arch Allergy Immunol, 119; 231-238, 1999.
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J. George,
A. Aron, Y. Levy, A. Ben-David, M. Hojnik, Y. Renaudineau, A. Zonana-Nachach,
P. Youinou, D. Harats, Y. Shoenfeld. Anti-cardiolipin, anti-endothelial-cell
and anti-malondialdehyde-LDL antibodies in uremic patients undergoing
hemodialysis: relationship with vascular access thrombosis and thromboembolic
events Human Antibodies. 9; 125-131, 1999.
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J. George, D.
Harats, E. Bakshi, Y. Levy, Y. Adler, B. Gilburd, Y. Shoenfeld.
Anti-oxidized-low density lipoprotein antibody determination as a predictor of
restenosis following percutaneous transluminal coronary angioplasty. Immunology
letters. 68; 263-266, 1999.
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J. George, Y.
Shoenfeld, D. Harats. The involvement of b2-glycoprotein I in human and
murine atherosclerosis. The Journal of Autoimmunity. 13; 57-60, 1999.
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Y. Levy, J.
George, BA Sela, P Langevitz, D Hatats, Y Shoenfeld. Elevated homocysteine
levels in patients with primary Raynaud’s syndrome. J. Rheumatology.
26; 2383-2385. 1999.
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A Afek, R
Manor, I Goldberg, L Ziporen, J. George, Polak-Charcon, MC Amigo,
Garcia-Torres, R Segal, Y Shoenfeld, J Kopolovic. Increased endothelial cell
expression of a3b1integrin in Libman-Sacks
endocarditis in the antiphospholipid syndrome. Lupus. 8; 502-509, 1999.
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Y. Levy, Y.
Sherer, A. Ahmed, P Langevitz, J. George, F. Fabrizzi, J.
Terryberry, M. Lorber, JB. Peter, Shoenfeld Y. A study of 20 SLE patients
with intravenous immunoglobulin-clinical and serologic response.Lupus 8;
705-712, 1999.
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A. Afek, J.
George, B. Gilburd..D. Harats, Y. Shoenfeld.Immunization with heat shock
protein 65 enhances early atherosclerosis in low-density lipoprotein receptor
deficient mice. J. Autoimmunity. 14; 115-121, 2000.
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Levy Y. Y.
Sherer, .J. George, J. Rovensky, J. Lukac, L. Rauova, P Porprac, P. Langevitz,
F. Fabbrizzi, Y. Shoenfeld Intravenous gammaglobulin treatment of patients with
lupus nephritis Semin. Arthritis Rheum. 29: 321-327, 2000.
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P. Keren, J.
George, A. Shaish, H. Levkovitz, Z. Janakovic, A. Afek, I. Goldberg, J.
Kopolovic, G. Keren, D. Harats. The effect of combined hyperglycemia and
hyperlipidemia on atherosclerosis in LDL-receptor deficient mice: establishment
of a combined model and association with heat shock protein 65 immunity.
Diabetes. 49; 1064-1069. 2000.