Prof. Basil
Rigas
Division of
Gastroenterology and Hepatology
Stony Brook
University, USA
Email: basil.rigas@stonybrook.edu
Qualifications
1977
Internship/Residency, Department of Medicine, Brown University
1975 DSc. (Biochemistry; with highest distinction), Athens University Medical School,
Greece
1972 M.D.
(summa cum laude), Athens University Medical School, Greece
Publications
(Selected)
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Rigas B, Van
Vunakis H, Levine L. The effect of phenothiazines and their metabolites on
prostaglandin production by rat basophilic leukemia cells in culture. Prostagland
Med.1981; 7:183-1035
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Rigas B, Lewis
RA, Austen KF, Corey EJ, Levine L. Identification and quantitation of
arachidonic acid metabolic products in rabbit, rat and human saliva.Arch
Oral Biol. 1983; 28:1031-1035
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Rigas B,
Levine L. Concentrations of arachidonic acid metabolites in human mixed saliva
are independent of flow rate. Arch Oral Biol. 1983; 28:1135-1137
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Rigas B,
Levine L. Human salivary eicosanoids: Circadian variation. Bioch Bioph Res
Commun. 1983; 115:201-205
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Rigas B,
Rosenfeld LE, Barwick KW, Enriquez R, Helzberg J, Batsford WP, Josephson ME,
Riely CA. Amiodarone hepatotoxicity: A clinicopathologic study of five patients.
Ann Int Med. 1986; 104:348-351
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Rigas B,
Welcher AA, Ward DC, Weissman SM. Rapid plasmid library screening using
RecA-coated biotinylated probes. Proc Natl Acad Sci USA. 1986;
83:9591-9595
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Lawrance SK,
Srivastava R, Rigas B, Chorney MJ, Gillespie GA, Smith CL, Cantor CR, Weissman
SM. Molecular approaches to characterization of megabase regions of DNA:
Applications to the human major histocompatibility complex. Cold Spring
Harbor Symp Quant Biol. 1986; 51:123-130
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Rigas B,
Levine L. Folk medicine inhibits mellitin-induced prostaglandin synthesis. Iatriki 1986;
49:91-94
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Rigas B,
Korenberg J, Merrill WW, Levine L: Prostaglandins E2 and F2a are
elevated in saliva of patients with cystic fibrosis. Am J Gastroent.
1989; 84:1408-1412
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van Vunakis H,
Tashkin DP, Rigas B, Simmons M, Gjika HB, Clark VA: Relative sensitivity and
specificity of salivary and serum cotinine in identifying tobacco-smoking
status of self-reported nonsmokers and smokers of tobacco and/or marijuana. Arch
Environ Health 1989; 44:53-58
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Rigas B,
Morgelo S, Goldman IS, Wong PTT. Human colorectal cancers display abnormal
Fourier-transform infrared spectra. Proc Natl Acad Sci USA, 1990,
87:8140-8144
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McDougall CJ,
Ngoi SS, Goldman IS, Godwin T, Felix J, DeCosse J, Rigas B. Reduced expression
of HLA class I and II antigens in colon cancer. Cancer Res 1990,
50:8023-8027
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Wong PTT,
Rigas B. Infrared spectra of microtome sections of human colon tissues. Appl
Spectrosc 1990, 44:1715-1718
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Staiano-Coico
L, Khandke L, Krane JF, Sharif S, Gottlieb AB, Kruger JG, Rigas B, Heim L. TGFa
and TGFb expression during sodium-n-butyrate induction of cornified envelops in
human keratinocytes: Evidence for subpopulation specific up-regulation of TGFb.
Exper Cell Res 1990, 191:286-291
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Rigas B,
Torosis J, McDougall CJ, Spiro HM. The circadian rhythm of biliary colic. J
Clin Gastroenterol, 1990, 12:409-414
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Ergun G, Rigas
B. Circadian periodicity of the time of onset of acute lower gastrointestinal
bleeding. Prog Clin Biol Res 1990;341B:221-8
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Minoli G,
Imperiale C, Gorla C, Spinzi GC, Rigas B. Circadian periodicity and other
clinical features of biliary pain. J Clin Gastroenterol, 1991,
13:546-549
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Wong PTT,
Papavassiliou ED, Rigas B. The phosphodiester stretching bands in the infrared
spectra of human tissues and cultured cells. Appl Spectrosc, 1991,
45:1563-1567
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Wong PTT, Wong
RK, Caputo TA, Godwin TA, Rigas B. Infrared spectroscopy of exfoliated human
cervical cells: Evidence of extensive structural changes during carcinogenesis. Proc
Natl Acad Sci USA, 1991, 88:10988-10992
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Rigas B, Wong
PTT. Human colon adenocarcinoma cell lines display infrared spectroscopic
features of malignant colon tissues. Cancer Res, 1992, 52:84-88
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Tsioulias G,
Godwin T, Goldstein M, Ngoi SS, McDougall CJ, DeCosse J, Rigas B. Loss of
colonic HLA antigens in familial adenomatous polyposis. Cancer Res,
1992, 52:3449-3452
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Wong PTT,
Goldstein SM, Grekin RC, Godwin TA, Pivik C, Rigas B. Distinct infrared spectroscopic
patterns of human basal cell carcinoma of the skin.Cancer Res, 1993,
53:762-765
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Tsioulias GJ,
Triadafilopoulos G, Goldin E, Rizos S, Papavassiliou ED, Rigas B. Expression of
HLA Class I antigens in sporadic adenomas and histologically normal mucosa of
the colon. Cancer Res, 1993, 53:2374-2378
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Rigas A, Rigas
B, Glassman M, Yen Y-Y, Lan SJ, Petridou E, Hsieh C-C, Trichopoulos D. Breast
feeding and maternal smoking in the etiology of Crohn's disease and ulcerative
colitis in childhood. Ann Epidemiol 1993, 3:387-392
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Rigas B,
Goldman IS, Levine L. Altered eicosanoid levels in human colon cancer. J Lab
Clin Med, 1993, 122:518-523
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Arvind P,
Papavassiliou ED, Tsioulias GJ, Duceman BW, Lovelace CIP, Geng W,
Staiano-Coico L, Rigas B. Lithocholic acid inhibits the expression of HLA class
I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B, and
-C. Molec Immunol, 1994, 31:607-614
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Papavassiliou
ED, Arvind P, Tsioulias GJ, Staiano-Coico L, Goldin E, Qiao L, Rigas B.
The effect of ethanol on the expression of HLA class I genes in human colon
adenocarcinoma cell lines. Canc Lett, 1994, 81:33-38
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Rigas B,
Tsioulias GJ, Allan C, Walli R, Brasitus TA. The effect of bile acids and
piroxicam on MHC antigen expression in rat colonocytes during colon cancer
development.Immunology, 1994, 83:319-323
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Pochapin MB,
Fine SN, Eisdorfer RM, Rigas B. Fecal occult bood testing in hospitalized
patients. J Clin Gastroenterol, 1994, 19:274-277
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Yu Sun, Rigas
B. Detection of biotinylated nucleic acids directly on agarose gels. Biotechniques, 1994,
16:782-784
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Schuman RW,
Rigas B. Bipolar electrocautery as an alternative to Nd:yag laser for the
treatment of the watermelon stomach. Gastrointest Endosc, 1995;
42:277-278
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Teintze M,
Arzimanoglou II, Lovelace CIP, Xu JZ, Rigas B. RecA-assisted rapid enrichment
of specific clones from model DNA libraries. Biochem Biophys Res Commun,
1995; 211:804-811
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Arvind P,
Papavassiliou ED, Tsioulias GJ, Lovelace CIP, Duceman B, Rigas B. PGE2 down-regulates the expression of HLA-DR in human colon
adenocarcinoma cell lines.Biochemistry, 1995; 34:5604-5609
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Shiff SJ, Qiao
L, Tsai L-L, Rigas B. Sulindac sulfide, an aspirin-like compound, inhibits
proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29
colon adenocarcinoma cells. J Clin Invest, 1995; 96:491-503
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Qiao L, Kozoni
V, Tsioulias GJ, Koutsos MI. Hanif R, Shiff SJ, Rigas B. Selected eicosanoids
increase the proliferation rate of human colon carcinoma cell lines and mouse
colonocytes in vivo. Biochem Biophys Acta, 1995; 1258:215-223
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Shiff SJ,
Koutsos MI, Qiao L, Rigas B. Nonsteroidal antiinflammatory drugs inhibit the
proliferation of colon adenocarcinoma cells: Effects on cell cycle and
apoptosis. Exp Cell Res, 1996; 222:179-188
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Goldberg Y,
Nassif II, Pittas A, Tsai L-L, Dynlacht D, Rigas B, Shiff SJ. The
anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon
cancer cells: Alterations in tumor suppressor and cell cycle-regulatory
proteins. Oncogene, 1996; 12:893-901
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Bortuzzo C,
Hanif R, Staiano-Coico L, Shiff SJ, Rigas B. The effect of leukotrienes B and
selected HETEs on the proliferation of colon cancer cells.Biochem Biophys
Acta, 1996; 1300:240-246
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Arvind P, Qiao
L, Papavassiliou ED, Goldin E, Koutsos MI, Rigas B. Aspirin and aspirin-like
drugs induce the expression of HLA-DR in HT29 colon adenocarcinoma cells. Int
J Oncology, 1996; 8:1207-1211
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Hanif R, Feng
J, Shiff SJ, Koutsos MI, Staiano-Coico L, Rigas B. NSAIDs inhibit the growth of
colon cancer cells by a prostaglandin-independent pathway.Biochem Pharmacol,
1996; 52:237-245
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Staiano-Coico L, Carano K, Babaar P, Rigas B, Higgins PJ. PAI-1 gene expression is growth state-regulated in cultured human
epidermal keratinocytes.Exp Cell Res 1996; 227:123-134
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Qiao L,
Koutsos M, Tsai L-L, Kozoni V, Guzman J, Shiff SJ, Rigas B. Staurosporine
inhibits the proliferation, alters the cell cycle distribution and induces
apoptosis in HT-29 human colon adenocarcinoma cells. Cancer Lett,
1996; 107:83-89
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Feng Y,
Papavassiliou ED, Arvind P, Tsioulias GJ, Rigas B. The effect of eicosanoids on
the expression of MHC genes in cultured human colon cancer cells and mouse
colon cells. Prost Leukotr Essent Fatty Acids, 1996; 55:373-378
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Cohenford M,
Bandhare PS, Rigas B, Krishnan K. Infrared spectroscopy of chemically preserved
cervical specimens on IR-transparent disposable filters. Mikrochim Acta[Suppl],
1997; 14:433-435
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Qiao L, Shiff
SJ, Rigas B. Sulindac sulfide inhibits the proliferation of colon cancer cells:
diminished expression of the proliferation markers PCNA and Ki-67. Cancer
Lett1997;115:229-234
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Aliprantis ET,
Merritt G, Prada F, Rigas B, Kashfi K. Fenretinide inhibits phorbol ester
induced cyclooxygenase-2 expression in human colon carcinoma cells. Biochem
Soc Trans 1997; 25:457S
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Cohenford M,
Godwin TA, Cahn F, Bhandari P, Caputo TA, Rigas B. Infrared spectroscopy of
normal and abnormal cervical smears: Evaluation by principal component
analysis.Gynecol Oncology, 1997; 66:59-65
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Hanif R, Qiao
L, Shiff SJ, Rigas B. Curcumin, a natural plant phenolic food additive,
inhibits cell proliferation and induces cell cycle changes in colon
adenocarcinoma cell lines by a prostaglandin independent pathway. J Lab
Clin Med, 1997; 130:576-584
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Qiao L, Shiff
SJ, Rigas B. Sulindac sulfide induces three subpopulations of colon cancer
cells, defined by PCNA/Ki-67 and DNA strand breaks. Bioch Biophys Acta,
1997; 1359:222-232
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Qiao L, Hanif
R, Sphicas E, Shiff SJ, Rigas B. Effect of aspirin on induction of apoptosis in
HT-29 human colon adenocarcinoma cells. Biochem Pharmacol, 1998;
55:53-64
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Qiao L, Shiff
SJ, Rigas B. Sulindac sulfide alters the expression of cyclin proteins in HT-29
colon adenocarcinoma cells. Int J Cancer, 1998; 76:99-104
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Cohenford M,
Rigas B. Cytologically normal cells from neoplastic cervical samples display
extensive structural abnormalities on infrared spectroscopy: Implications for
tumor biology. Proc Natl Acad Sci USA, 1998; 95:15327-15332Rigas B,
Feretis C, Papavassiliou ED. J.
Lykoudis: An unappreciated discoverer of the infectious etiology and treatment
of peptic ulcer disease. Lancet, 1999; 354:1634-1635
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Scotiniotis I,
Rokkas T, Furth EE, Rigas B, Shiff SJ. Changes in apoptosis and proliferation
in Helicobacter pylori-associated gastritis and intestinal
metaplasia. Int J Cancer2000; 85: 192-200
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Rigas B, LaGuardia K, Cohenford M, Bhandari P,
Godwin TA, Caputo TA, Cohenford M. Infrared
spectroscopic study of cervical smears in HIV patients: An insight into
cervical carcinogenesis. J Clin Lab Med, 2000; 135:26-31
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Rigas B, Shiff
SJ. Is an effect of cyclooxygenase required for the chemopreventive effect of
NSAIDs in colon cancer? A model reconciling the current contradiction. Medical
Hypotheses, 2000, 54:210-215
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Kozoni V,
Tsioulias G, Shiff SJ, Rigas B. The effect of lithocholic acid on proliferation
and apoptosis during the early stages of colon carcinogenesis. Differential
effect on apoptosis in the presence of a colon carcinogen. Carcinogenesis, 2000;
21:999-1005
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Merritt G,
Aliprandis ET, Prada F, Rigas B, Kashfi K. The retinoid fenretinide
inhibits proliferation and downregulates cyclooxygenase-2 gene expression in
human colon adenocarcinoma cell lines. Cancer Lett, 2001; 164:15-23
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Williams J, Borgo S, Hasan I, Castillo E, Traganos F, Rigas
B. NO-releasing NSAIDs alter the kinetics of human colon cancer cell lines more
effectively than traditional NSAIDs. Implications for colon cancer
chemoprevention. Cancer Res, 2001; 61:3285-3289