Prof. Jacques Thibodeau

Université de Montréal, Canada

E-mail: Jacques.thibodeau@umontreal.ca

Qualifications

1986-1991 Ph.D. (biologie moléculaire), Université Laval, Québec (Québec), Canada

1982-1985 M.Sc. (microbiology), Université de Sherbrooke, Sherbrooke (Québec), Canada

1979-1982 B.Sc. (biology), Université Laval, Québec (Québec), Canada

Publications (Selected)

1. Denis, F., Shoukry, N., Delcourt, M., Thibodeau, J., Labrecque, N., Mcgrath, H., Munzer, S., Seidah, N.G., and Sékaly, R.P. (2000) Alternative Proteolytic Processing of Mouse Mammary Tumor Virus Superantigens. J. Virol., 74: 3067-3073.
2. Brunet, A., Samaan, A., Deshaies, F., Kindt, T.J. and Thibodeau, J. (2000) Functional Characterization of a Di-leucine Lysosomal Sorting Motifs in the Cytoplasmic Tail of HLA-DOb. J. Biol. Chem., 275: 37062-37071.
3. Lavoie, P.M., Mcgrath, H., Shoukry, N.H., Cazenave, P.A., Sékaly, R.P. and Thibodeau, J. (2001) Quantitative relationship between MHC class II/superantigen complexes and the balance of T cell activation versus death. J.Immunol., 166: 7229-7237.
4. Faubert, A., Samaan, A. and Thibodeau, J. (2002) Functional Analysis of Tryptophans a62 and b120 on HLA-DM. J. Biol. Chem., 277: 2750-2755.
5. Azar, G. and Thibodeau, J. (2002) Human Endogenous Retrovirus IDDMK1,222 and Mouse Mammary Tumor Virus Superantigens Differ in Their Ability to Stimulate Murine T Cell Hybridomas. Immunol. Letters, 81: 87-91.
6. Khalil, H., Deshaies, F., Bellemare-Pelletier, A., Brunet, A., Faubert, A., Azar, G. and Thibodeau, J. (2002) CIITA-induced expression of HLA-DOb in HeLa cells. Tissue Antigens 60: 372-382.
7. Lapointe, R., Bellemare-Pelletier, A., Housseau, F., Thibodeau, J. and Hwu, P. (2003) CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen presenting cells and can generate specific T cells. Cancer Research, 63: 2836-2843.
8. Bouillon, M., El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W. (2003) Lipid Raft-dependent and -independent signaling through HLA-DR molecules. J. Biol. Chem. 278: 7099-7107.
9. Khalil, H., Brunet, A., Saba, I., Terra, R., Sékaly, R.P. and Thibodeau, J. (2003) The MHC class II b chain cytoplasmic tail overcomes the invariant chain p35-encoded endoplasmic reticulum retention signal. Int. Immunol., 15: 1249-1263.
10. El Fakhry, Y., Bouillon, M., Léveillé, C., Brunet, A., Khalil, H., Thibodeau, J., and Mourad, W. (2004) Delineation of the HLA-DR region and the residues involved in the association with the cytoskeleton. J. Biol. Chem., 279: 18472-80.
11. Lapointe, R., Thibodeau, J. and Hwu, P. (2004) Correspondence re R. Lapointe et al., CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells. Cancer Res. 64: 4056-4057.
12. Martin, G., Beauséjour, Y., Thibodeau, J. and Tremblay, M.J. (2005) Envelope glycoproteins are dispensable for insertion of host HLA-DR molecules within nascent human immunodeficiency virus type 1 virions. Virology, 335: 286-290.
13. Bellemare-Pelletier, A., Tremblay, J., Beaulieu, S., Boulassel, R., Routhy, J.P., Massie, B., Lapointe, R. and Thibodeau, J. (2005) HLA-DO transduced in human monocyte-derived dendritic cells modulates antigen presentation.J. Leuk. Biol., 78: 95-105.
14. Azar, G., Sékaly, R.P. and Thibodeau, J. (2005) A defective viral superantigen-presenting phenotype in HLA-DR transfectants is corrected by CIITA. J. Immunol. 174: 7548-7557.
15. Deshaies, F., Brunet, A., Diallo, D., Denzin, L., Samaan, A. and Thibodeau, J. (2005) A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM. Proc. Natl. Acad. Sci. USA 102: 6443-6448.
16. Khalil, H, Brunet, A. and Thibodeau, J. (2005) A three amino acid-long DRb cytoplasmic tail is sufficient to overcome ER retention of Iip35. J. Cell Sci. 118:4679-4687. Funded by Boehringer Ingelheim and Diabète Québec.
17. Deshaies F. et Thibodeau J. (2005) HLA-DO: Régulateur de la Réponse Immunitaire. Médecine/Sciences. 21: 11-13.
18. Clément, M., Tremblay, J., Lange, M., Thibodeau, J. and Belhumeur, P. (2006) Whey derived free fatty acids suppress germination of Candida albicans in vitro. FEMS Yeast Research. 7: 276-285. Funded by Saputo.
19. Finzi, A., Brunet, A., Xiao, Y., Thibodeau, J. and Cohen, E.A. (2006) Major Histocompatibility Complex class II molecules promote human immunodeficiency virus type I assembly and budding to late endosomal/multivesicular body compartments. J. Virol. 80:9789-9797. Funded by the CIHR and FRSQ.
20. De Gassart, A., Camossetto, A., Thibodeau, J., Ceppi, M., Catalan, N., Pierre, P. and Gatti, E. (2008) MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I downregulation. Proc. Natl. Acad. Sci. USA 105: 3491-3496 Funded by the CIHR.