Dr. Purnachandra Nagaraju Ganji

Emory University, USA

E-mail: gpcnraju@hotmail.com

Qualifications

2008–2010 Post Doctoral Research Associate, University of Illinois, USA

2006–2008 Post Doctoral Research Associate, Department of Biology, University of Central Florida, USA

2004–2005 Postdoc, Dept of Biology, National Changhua University of Education, Changhua, Taiwan

Publications (Selected)

1. Keith I. Block, et al Ganji P Nagaraju et al. A broad-spectrum integrative design for cancer prevention and therapy. Semin Cancer Biol. 2015 (minor revision).
2. Zhang SY, Zhang SQ, Ganji P Nagaraju, Bassel El-Rayes. Biomarkers for personalized medicine in GI cancers. Mol Aspects Med. 2015 Jun 5. pii: S0098-2997(15)00037-0. doi: 10.1016/j.mam.2015.06.002 (In press).
3. Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, Rathmell WK, Generali D, Nagaraju GP, El-Rayes B, et al. Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol. 2015 Jan 16. pii: S1044-579X(15)00002-4.
4. Nagaraju GP, Long T, Park W, Willingham FF, Landry JC, Sullivan P, Taliaferro-Smith L, Diaz R, El-Rayes BF. Heat shock protein 90 (HSP90) promotes epithelial to mesenchymal transition invasion and migration in colorectal cancer. Molecular Carcinogenesis. 2015 (In press).
5. LaTonia D Taliaferro-Smith, Elaine M. Oberlick, Tongrui Liu, Tanisha Mcglothen, Tiffanie Alcaide, Rachel Tobin, Siobhan Donnelly, Rachel Commander, Erik Kline, GP Nagaraju, Lauren Havel, Adam Marcus, Rita Nahta, Ruth M. O'Regan. FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells. Oncotarget. 2015 Mar 10;6(7):4757-4772.
6. Nagaraju GP, Zhu S, Ko J, Nakkana A, Ramesh K, Synder J, Shoji M, EL-Rayes B. Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer. Cancer Letters. 2015 Feb 28; 357(2):557-65.
7. Nagaraju GP, Aliya S, Alese OB. Role of adiponectin in obesity related gastrointestinal carcinogenesis. Cytokine & Growth Factors Reviews. 2015 Feb;26(1):83-93.
8. Nagaraju GP, Alese OB, Landry JC, Diaz R, El-Rayes BF. HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy. Oncotarget. 2014 Oct 30;5 (20):9980-91.
9. Nagaraju GP, Dontula R, El-Rayes BF, Lakka SS. Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis. Carcinogenesis. 2014 May;35 (5):967-73.
10. Colbert LE, Petrova, AV, Fisher SB, Pantazides BG, Madden MZ, Hardy CW, Warren MD, Pan Y, Nagaraju GP, et al., CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer. Cancer Res. March 13, 2014; DOI: 10.1158/0008-5472.
11. G. Seeta Rama Raju, E. Pavitra, Nagaraju GP, Ramesh Kandimalla, Bassel F. El-Rayes, and Jae Su Yu. Imaging and curcumin delivery in pancreatic cell lines using PEGylated α-Gd₂(MoO₄)₃ mesoporous particles. Delton Transactions 2014; 43:3330-3338.
12. Prasad GL, Naik BR, Ko JE, Nagaraju GP. Effects of naloxone, serotonin, and dopamine on reproduction of the freshwater crab Barytelphusa guerini. J Exp Zool A Ecol Genet Physiol. 2014; 321(3):173-82.
13. Nagaraju GP, Zhu S, Wen J, Farris AB, Adsay VN, Diaz R, Snyder JP, Mamoru S, El-Rayes BF. Novel synthetic curcumin analogues EF31 and UBS109 are potent DNA hypomethylating agents in pancreatic cancer. Cancer Lett. 2013 Aug 7. doi:pii: S0304-3835(13)00575-2. 10.1016/j.canlet.2013.08.002.
14. Nagaraju GP, SF Zafar, BF El‐Rayes. Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases Nutrition reviews 2013; 71 (8):562-572.
15. Nagaraju GP and Bassel F. El-Rayes. SPARC and DNA methylation: possible diagnostic and therapeutic implications in Gastrointestinal Cancers. Cancer letters 2013; 328(1): 10-17.
16. Nagaraju GP, Park W, Wen J, Mahaseth H, Landry J, Farris AB, Willingham F, Sullivan PS, Proia DA, El-Hariry I, Taliaferro-Smith L, Diaz R, El-Rayes BF. Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3. Angiogenesis. 2013 Oct; 16(4):903-17.
17. G. Seeta Rama Raju, E. Pavitra, Nagaraju GP, Ramesh Kandimalla, Bassel F. El-Rayes, and Jae Su Yu. PEGylated α-Gd₂(MoO₄)₃ Mesoporous Flowers: Synthesis, Characterization, and Biological Application. Crystal growth and Design. 2013 Sep 4; 13(9): 4051–4058.
18. Kung PC, Wu SH, GP Nagaraju, Tsai WS, Lee CY. Crustacean hyperglycemic hormone precursor transcripts in the hemocytes of the crayfish Procambarus clarkii: novel sequence characteristics relating to gene splicing pattern and transcript stability. Gen Comp Endocrinol 2013; 186, 80-84.
19. Nagaraju GP, Sheik Aliya, Syed F. Zafar, Riyaz Basha, Roberto Diaz and Bassel F. El-Rayes. The impact of curcumin on breast cancer. Integr Biol (Camb). 2012 Sep 21; 4(9):996-1007.
20. Zafar SF, Nagaraju GP, Bassel F. El-Rayes. Developing histone deacetylase inhibitors in the therapeutic armamentarium of pancreatic adenocarcinoma. Expert Opin Ther Targets. 2012 Jul; 16(7):707-18.
21. Chetty C, Dontula R, Nagaraju GP, Gujrati M, Lakka SS. SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells. Biochem Biophys Res Commun. 2012 Jan 13; 417(2):874-9.
22. Nagaraju GP, Sharma D. Anti-cancer role of SPARC, an inhibitor of adipogenesis. Cancer Treat Rev. 2011 Nov; 37(7): 559-66.
23. Nagaraju GP, Nalla AK, Gupta R, Mohanam S, Gujrati M, Dinh DH, Rao JS. siRNA-mediated downregulation of MMP-9 and uPAR in combination with radiation induces G2/M cell-cycle arrest in Medulloblastoma. Mol Cancer Res. 2011 Jan; 9(1): 51-66.
24. Nagaraju GP, Rajitha B, Borst DW. “Molecular cloning and sequence of retinoid X receptor in the green crab Carcinus maenas: a possible role in female reproduction.” J Endocrinol. 2011 Sep; 210(3): 379-90.
25. Nagaraju GP, Kumari NS, Prasad GL, Naik BR, Borst DW Computational analysis and structure predictions of CHH-related peptides from Litopenaeus vannamei. Integr Biol (Camb). 2011 Mar; 3(3): 218-24.
26. Nagaraju GP. Is methyl farnesoate a crustacean hormone? Aquaculture 2007; 272: 39-54.
27. Nagaraju GP. Reproductive regulators in decapod crustaceans: an overview. J Exp Biol. 2011 Jan1; 214(Pt 1): 3-16.
28. Nagaraju GP, Prasad GL, Taliaferro-Smith L, Aruna BV, Naik BR, Sekhar YN. Computational analysis of the structural basis of ligand binding to the crustacean retinoid X receptor. Comp Biochem Physiol Part D Genomics Proteomics. 2010 Dec; 5(4): 317-24.