The Center on Aging and Associated Diseases

Helmy Institute of Medical Sciences

Zewail City of Science and Technology, Egypt

Professor and Director

Department of Anesthesiology

University of California San Diego, USA

Associate Professor(on sabbatical leave)

E-mail: sameh.ali@zewailcity.edu.eg, ssali@ucsd.edu

Qualifications

1997 Ph.D.,Tohoku University, Japan, Magnetic Effects on Free Radical Reactions

1994 M.Sc.,Tohoku University, Japan, Photochemistry

1988 B.Sc., Ain Shams University, Egypt, Chemistry

Publications (Selected)

1. Ali SS, Hardt JI, Quick KL, Kim-Han JS, Erlanger BF, Huang T, Epstein CJ and Dugan LL.(2004) A Biologically Effective Fullerene (C60) Derivative with Superoxide Dismutase Mimetic Properties. Free Rad. Biol. Med., 37:1191-1202.
2. Ali SS, Xiong C, Lucero J, Dugan LL, Quick KL. (2006) Gender differences in free radical homeostasis during aging: Shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell, 5(6) 565-574.
3. Quick KL, Ali SS, Arch R, Xiong C, Wozniak D, Dugan LL. (2006) A carboxyfullerene SOD mimetic extends the lifespan of mice. Neurobiology of Aging, Neurobiology of Aging, E-Pub 9/06, Print 29:117-28 (2008).
4. Behrens, MM, Ali, SS, Dao, DN, Lucero, J, Shekhtman, G, Quick, KL, Dugan, LL. (2007) Brain NADPH-oxidase mediates ketamine effects on parvalbumin-expressing fast-spiking interneurons. Science 318:1645-1647.
5. Cuddihy, SL, Ali, SS, Musiek, E, Lucero, J, Kopp, S, Morrow, J, Dugan, LL. (2008) Prolongeda-tocopherol deficiency decreases oxidative stress and unmasksa-tocopherol-dependent regulation of mitochondrial function in brain. J. Biol. Chem., 14; 283(11): 6915-6924.
6. Ali SS*, Hardt JI, and Dugan LL (2008) SOD activity of carboxyfullerenes predicts their neuroprotective efficacy: A structure-activity study. Nanomedicine: Nanotechnology, Biology, and Medicine, 4(4):283-294.
7. Behrens, MM, Ali, SS, Dugan, LL. (2008) Interleukin-6 mediates the increase in NADPHoxidase in the ketamine model of schizophrenia. J. Neurosci., 17; 28(51):13957-13966.
8. Dugan, LL, Ali, SS, Shekhtman, G, Roberts, A.J, Lucero, J, Quick, KL, Behrens, MM (2009) IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase. PLoS One, 4(5): e5518.7
9. Douglas, RM, Kanaan, A, Rivero, MD, Dugan, LL, Haddad, GG, and Ali, SS*. (2010) Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. American J. Physiol. Cell Physiol. 298:1594-1602.
10. Ali, SS*, Marcondes, MC, Bajova, H, and Conti, B. (2010) Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures. J. Biol. Chem., 285(42):32522-8.
11. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. (2010) Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One 5(12):e15697.
12. Ali, SS, Young, J, Wallace, C, Gresack, J, Jeste, D, Geyer M, Dugan, L, and Risbrough, V. (2011) Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice. Brain Research, 1368:65-70.
13. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM (2011). Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J. Am. Coll. Cardiol. 57(22):2273-83.
14. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. (2011) Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J. Biol. Chem., 286(38):33310-21.
15. Kawaraguchi, Y, Horikawa, YT, Murphy, AN, Murray, F, Miyanohara, A, Ali, SS, Patel, PM, Roth, Ph.D., DM, and Patel, HH (2011) Volatile anesthetics protect cancer cells against TRAIL-induced apoptosis via caveolins. Anesthesiology, 115(3):499-508.
16. Zhao H, Ali SS*, Haddad GG (2012) Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production? Antioxidants & Redox Signaling, 16(10):1071-6.
17. Pamenter, ME, Ali, SS (co-first author), Yao, H, Dugan, LL, and Haddad, GG. (2012) An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons. Brain Research, May 3;1452:165-72.
18. Ali, SS*, Dugan, LL, Haddad, GG, and Zhou, D. (2012). Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One, 7(5):e36801.
19. Fridolfsson, HN, Karawaguchi, Y, Ali, SS (co-first author), Panneerselvam, M, Balijepalli, RC Niesman, IR, Finley, CJ, Okada, H, Moreno, A, Jennings, M, Kidd, MW, Patel, PM, Miyanohara, A, Chen, O, Lesnefsky, Head, BP, Roth, D, Insel, PA, and Patel, HH. (2012) Memebrane-mitochondria symbiosis: Caveolin as a control point in stress adaptation. FASEB J. 2012 Nov;26(11):4637-49. doi: 10.1096/fj.12-215798.
20. Tsai C-Y, Finley JC, Ali SS, Patel HH, and Howell SB. (2012) Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling, Biochemical Pharmacology, 84(8): 1007-1013.
21. Mira Sastri, Kristofer J Haushalter, Mathivadhani Panneerselvam, Philip Chang, Heidi Fridolfsson, J Cameron Finley, Daniel Ng, Jan M Schilling, Atsushi Miyanohara, Michele E Day, Hiro Hakozaki, Susanna Petrosyan, Antonius Koller, Charles C King, Manjula Darshi, Donald K Blumenthal, Sameh Saad Ali, David M Roth, Hemal H Patel, Susan S Taylor. (2013) P.N.A.S, 110(5):E387-E396.
22. Mathivadhani Panneerselvam, Sameh S Ali (co-first author), J Cameron Finley, Sarah E Kellerhals, Michael Y Migita, Brian P Head, Piyush M Patel, David M Roth, Hemal H Patel. (2013) Molecular nutrition & food research, DOI: 10.1002/mnfr.201300026.
23. Laura L Dugan1,Young-Hyun You, Sameh S. Ali, Maggie Diamond-Stanic, Satoshi Miyamoto, Anne-Emilie DeCleves, Aleksander Andreyev, Tammy Quach, San Ly, Grigory Shekhtman, William Nguyen, Andre Chepetan, Thuy P. Le, Lin Wang, Ming Xu, Kacie P. Paik, Agnes Fogo , Benoit Viollet, Anne Murphy, Frank Brosius, Robert K. Naviaux, and Kumar Sharma (2013) Mitochondrial Function and Superoxide Production is Reduced in the Diabetic Kidney and Restored by AMPK Activation. J. Clinical Investigations. 123 (11), 4888.

Profile Details:

http://www.zewailcity.edu.eg/research-institutes/caad/staff/about-the-director/