Dr. Kenji Kabashima

Kyoto University, Japan


2003 Ph.D., Kyoto University, Faculty of Medicine

1996 M.D., Kyoto University, Faculty of Medicine

Publications (Selected)
  1. Tomura M, Honda T, Tanizaki T, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K*. Activated regulatory T cells are major T cell type emigrating from sensitized skin.J Clin Invest (in press)
  2. Honda T, Nakajima S, Egawa G, Ogasawara K, Malissen B, Miyachi Y, Kabashima K*. 2009. Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity. J Allergy Clin Immunol (in press)
  3. Moniaga CS, Egawa G, Kawasaki H, Hara-Chikuma M, Honda T, Tanizaki H, Nakajima S, Otsuka A, Matsuoka H, Kubo A, Sakabe JI, Tokura Y, Miyachi Y, Amagai M, Kabashima K* Flaky tail mouse as a possible model of atopic dermatitis.Am J Patho l (in press)
  4. KabashimaK*, Sakabe JI, Yoshiki R, Tabata Y, Kohno K, Tokura Y. 2009. Involvement of Wnt signaling in dermal fibroblasts. Am J Pathol (in press)
  5. Honda T, Matsuoka T, Ueta M, Kabashima K, Miyachi Y, Narumiya S. 2009. Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity. J Allergy Clin Immunol (in press)
  6. HattoriK, Nishikawa M, Watcharanurak K, Ikoma A, Kabashima K, Toyota H, Takahashi Y, Takahashi R, Watanabe Y, and Takakura Y. Sustained exogenous expression of therapeutic levels of interferongameliorates atopic dermatitis in NC/Nga mice via Th1 polarization. J Immunol (in press)
  7. Sugita, K., Kabashima, K. *, Yoshiki, R., Ikenouchi-Sugita, A., Tsutsui, M., Nakamura, J., Yanagihara, N., and Tokura, Y. 2009. Inducible Nitric Oxide Synthase Downmodulates Contact Hypersensitivity by Suppressing Dendritic Cell Migration and Survival. J Invest Dermatol (in press)
  8. Yoshiki, R., Kabashima, K., Sugita, K., Atarashi, K., Shimauchi, T., and Tokura, Y. 2009. IL-10-producing Langerhans cells and regulatory T cells are responsible for depressed contact hypersensitivity in grafted skin. J Invest Dermatol 129: 705-713.
  9. Nakashima, D., Kabashima, K. *, Sakabe, J., Sugita, K., Kobayashi, T., Yoshiki, R., and Tokura, Y. 2008. Impaired initiation of contact hypersensitivity by FTY720. J Invest Dermatol 128: 2833-2841.
  10. Mori, T., Kabashima, K. *, Yoshiki, R., Sugita, K., Shiraishi, N., Onoue, A., Kuroda, E., Kobayashi, M., Yamashita, U., and Tokura, Y. 2008. Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines. J Invest Dermatol 128: 1719-1727.
  11. Koga, C., Kabashima, K. *, Shiraishi, N., Kobayashi, M., and Tokura, Y. 2008. Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol 128: 2625-2630.
  12. Nagamachi, M., Sakata, D., Kabashima, K. (equally contributed 1stauthor), Furuyashiki, T., Murata, T., Segi-Nishida, E., Soontrapa, K., Matsuoka, T., Miyachi, Y., and Narumiya, S. 2007. Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. J Exp Med 204: 2865-2874.
  13. Kabashima, K. *, Shiraishi, N., Sugita, K., Mori, T., Onoue, A., Kobayashi, M., Sakabe, J., Yoshiki, R., Tamamura, H., Fujii, N., et al. 2007. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol 171: 1249-1257.
  14. Kabashima, K., Haynes, N.M., Xu, Y., Nutt, S.L., Allende, M.L., Proia, R.L., and Cyster, J.G. 2006. Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism.J Exp Med 203: 2683-2690.
  15. Kabashima, K., Banks, T.A., Ansel, K.M., Lu, T.T., Ware, C.F., and Cyster, J.G. 2005. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22: 439-450.
  16. Katagiri, K., Ohnishi, N., Kabashima, K., Iyoda, T., Takeda, N., Shinkai, Y., Inaba, K., and Kinashi, T. 2004. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. NatImmunol 5: 1045-1051
  17. Kabashima, K., Sakata, D., Nagamachi, M., Miyachi, Y., Inaba, K., and Narumiya, S. 2003. Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat Med 9: 744-749.
  18. Kabashima, K., Murata, T., Tanaka, H., Matsuoka, T., Sakata, D., Yoshida, N., Katagiri, K., Kinashi, T., Tanaka, T., Miyasaka, M., et al. 2003. Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. NatImmunol 4: 694-701.
  19. Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. 2002. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.J Clin Invest 109: 883-893.
  20. Matsuoka, T., Hirata, M., Tanaka, H., Takahashi, Y., Murata, T., Kabashima, K., Sugimoto, Y., Kobayashi, T., Ushikubi, F., Aze, Y., et al. 2000. Prostaglandin D2 as a mediator of allergic asthma. Science 287: 2013-2017.
  21. Taga, K., Yamauchi, A., Kabashima, K., Bloom, E.T., Muller, J., and Tosato, G. 1996. Target-induced death by apoptosis in human lymphokine-activated natural killer cells. Blood 87: 2411-2418.
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