Dr. Robert A. Drewell

Harvey Mudd College, Canada

Email:drewell@hmc.edu

Qualifications

2011  Associate Professor, Harvey Mudd College

1999 Ph.D., University of Cambridge, Molecular & Developmental Biology
1996 B.Sc., University of London, Molecular Genetics

1. DNA methylation in social insects: an emerging role in form and function. R. A. Drewell and B. P. Oldroyd. Submitted.
2. Transcriptional repression by the proximal exonic region at the human TERT gene. T. C. Wong, E. S. Sokol, A. N. Schep, M. Punjiya, D. A. Tran, D. Allen and R. A. Drewell. Submitted.
3. Molecular dissection of cis-regulatory modules at the Drosophila bithorax complex reveals critical transcription factor signature motifs. M. O. Starr, M. C. W. Ho, E. J. M. Gunther, Y. K. Tu, A. S. Shur, S. E. Goetz, M. J. Borok , V. Kang and R. A. Drewell. Submitted.
4. Disruption of the Abdominal-B promoter tethering element results in a loss of long-range enhancer-directed Hox gene expression in Drosophila. M. C. W. Ho, B. J. Schiller , O. S. Akbari, E. Bae and R. A. Drewell. 2011. PLoS One 6: e16283.
5. Characterization of an ultra-conserved putative cis-regulatory module at the mammalian telomerase reverse transcriptase gene. D. A. Tran, T. C. Wong, A. N. Schep and R. A. Drewell. 2010. DNA and Cell Biology 29: 499-508.
6. Dissecting the regulatory switches of development: Lessons from enhancer evolution in Drosophila. M. J. Borok, D. A. Tran, M. C. W. Ho and R. A. Drewell. 2010. Development 137: 5-13.
7. Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila. M. C. W. Ho, H. Johnsen, S. E. Goetz, B. J. Schiller, E. Bae, D. A. Tran, A. S. Shur, J. M. Allen, C. Rau , W. Bender, W. W. Fisher, S. E. Celniker and R. A. Drewell. 2009. PLoS Genetics 5: e1000709.
8. Non-genic transcription at the Drosophila bithorax complex – functional activity of the dark matter of the genome. M. C. W. Ho, B. J. Schiller, S. E. Goetz and R. A. Drewell. 2009. International Journal of Developmental Biology 53: 459-468.
9. A concise Drosophila laboratory module to introduce the central concepts of genetics. M. C. W. Ho , D. R. Venema and R. A. Drewell. 2008. Drosophila Information Service 91: 164-168.
10. Between transcription and translation: re-defining RNA and regulation. M. C. W. Ho, B. J. Schiller, S. E. Goetz, J. M. Allen and R. A. Drewell. 2008. Fly 2: 152-155.
11. A novel promoter tethering element regulates enhancer-driven gene expression at the bithorax complex in the Drosophila embryo. O. S. Akbari, E. Bae, H. Johnsen, A. Villaluz, D. Wong and R. A. Drewell. 2008. Development 135: 123-131.
12. The Abdominal-B promoter tethering element mediates promoter-enhancer specificity at the Drosophila bithorax complex. O. S. Akbari, B. J. Schiller, S. E. Goetz, M. C. W. Ho, E. Bae and R. A. Drewell. 2007. Fly 1: 337-339
13. Chromatin looping mediates boundary element promoter interactions. S. Celniker and R. A. Drewell. 2007. Bioessays 29: 7-10.
14. The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila. K. L. Arney, E. Bae, C. E. Olsen and R. A. Drewell. 2006. Development, Genes and Evolution 216: 811-819.
15. Unraveling cis-regulatory mechanisms at the abdominal-A and Abdominal-B genes in the Drosophila bithorax complex. O. S. Akbari, A. Bousum, E. Bae and R. A. Drewell. 2006. Developmental Biology 293: 294-304.
16. The 3’ portion of the mouse H19 Imprinting-Control Region is required for proper tissue-specific expression of the Igf2 gene. H. Hagège, R. Nasser, M. Weber, L. Milligan, N. Aptel, C. Jacquet, R.A. Drewell, L. Dandolo, M.A. Surani, G. Cathala, T. Forné. 2006. Cytogenetic & Genome Research 113: 230-237.
17. Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex. R. A. Drewell, E. Bae, J. Burr and E. B. Lewis. 2002. Proceedings of the National Academy of Sciences USA 99: 16853-16858.
18. Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex. E. Bae, V. C. Calhoun, M. Levine, E. B. Lewis and R. A. Drewell. 2002. Proceedings of the National Academy of Sciences USA 99: 16847-16852.
19. Novel conserved elements upstream of the H19 gene are transcribed and act as mesoderm enhancers. R. A. Drewell, K. L. Arney, T. Arima, S. C. Barton, J. D. Brenton and M. A. Surani. 2002. Development 129: 1205-1213
20. Methylation-dependent silencing at the H19 imprinting control region by MeCP2. R. A. Drewell, C. J. Goddard, J. O. Thomas and M. A. Surani. 2002. Nucleic Acids Research 30: 1139-1144