Prof. Martin John Mangino
Michigan State University, USA



1985–1987 Postdoctor, Biochemistry, Washington University School of Medicine, USA

1982–1985 Ph.D., Physiology, Michigan State University, USA
1977–1981 B.Sc., Physiology, Michigan State University, USA

Publications (Selected)

  1. Mangino, M.J. and C.C. Chou. Arachadonic acid and postprandial intestinal hyperemia, Am. J. Physiol. 242: G521 - G527, 1984
  2. Chou, C.C., M.J. Mangino, and D.R. Sawmiller, Gastrointestinal Hormones and Intestinal Blood Flow, In: Physiology of the Intestinal Circulation, Edited by A.P. Shepherd and D.N.Granger, Raven Press, New Your, 1984, pp. 121 – 130
  3. Mangino, M.J, Contributions of endogenous prostaglandins to the postprandial intestinal hyperemia, Michigan State University Press, 1985
  4. Mangino, M.J. and C.C. Chou, Thromboxane synthesis inhibition and postprandial intestinal hyperemia and oxygenation, Am. J. Physiol. 250: G64 - G69, 1986.
  5. Mangino, M.J., C.B. Anderson, K. DeSchryver, J.D. Tyler, G.A. Sicard, and J. Turk, Eicosanoid synthesis associated with renal allograft rejection, Proceedings of the First Alexis Carrel Symposium on Lipid Mediators in Organ Transplantation, Trans.
  6. Turk, J., A. Boeher, W.T. Stump, and M.J. Mangino, Quantitation of the 2-lyso metabolite of platelet activating factor by gas chromatography-negative ion chemical ionization-mass spectrometry, J. Chromotography 575: 183 - 196, 1992.
  7. Mangino, M.J., J. Zografakis, M.K. Murphy, and C.B. Anderson, An improved and simplified tissue extraction method for quantitating long chain acyl-Coenzyme-A thioesters with picomolar detection using high-performance liquid chromatography, J. Chromatography Biomed. Appl. 577: 157 - 162, 1992.
  8. Goss, J.A., M.J. Mangino, and M.W. Flye, Prostaglandin E2 production during hepatic regeneration downregulates Kupffer cell IL-6 production, Ann. Surg. 215: 553 - 560, 1992.
  9. Mangino, M.J., M.K. Murphy, A. Weiss, and C.B. Anderson, Characterization of platelet activating factor receptors on canine T-lymphocytes, J. Immunology 151: 5310 - 5318, 1993.
  10. Roland, C., J. Goss, M.J. Mangino, D. Hafenrichter, and M.W. Flye, Autoregulation by eicosanoid of human Kupffer cell secretory products: A study of interleukin 1, interleukin 6, tumor necrosis factor , transforming growth factor, and nitric oxide, Ann. Surg. 219: 389 - 399, 1994.
  11. Mangino, M.J., M.K Murphy, and C.B. Anderson, Effects of the arachadonate 5-lipoxygenase synthesis inhibitor A-64077 in intestinal ischemia-reperfusion injury, J. Pharmacol. Exp. Ther. 269: 75 - 81, 1994.
  12. Roland, C., Mangino, M.J., and Flye, M.W, Lanthanide "blockade" of antigen-presenting cells suppresses lymphocyte proliferation by inducing nitric oxide synthesis, J. Surg. Res. 54: 401 - 410, 1993.
  13. Mangino, M.J., Murphy, M., Bohrer, A., and Turk, J, Platelet activating factor synthesis and metabolism in intestinal ischemia-reperfusion injury, Mediators Inflammation 3: 393 - 395, 1994.
  14. Hafenrichter, D.J., C.R. Roland, M.J. Mangino, and M.W. Flye, The Kupffer cell in endotoxin tolerance: Mechanisms of protection against letha, endotoxemia. Shock 2: 251 - 256, 1994.
  15. Mangino, J.E., B. Kotadia, and M.J. Mangino, Characterization of hypothermic intestinal ischemia-reperfusion injury, Effects of glycine, Transplantation 62: 173 - 178, 1996
  16. Mangino, M.J., J.E. Mangino, M.K. Murphy, and C.B. Anderson, Mucosal arachidonic acid metabolism in intestinal preservation injury, Cryobiology 33: 404 - 412, 1996.
  17. Mangino, M.J., J.E. Mangino, B. Kotadia, and M. Sielczak, Effects of the 5-lipoxygenase inhibitor A-64077 on intestinal hypothermic organ preservation injury, J. Pharmacol. Exp. Ther. 281: 950 - 956, 1997.
  18. Torbati, D., M.J. Mangino, J. Ramirez, B. Totapally and J. Wolfsdor, Exogenous carbon dioxide increases oxygen carrying capacity and hemoglobin concentration in ventillated dogs, Crit. Care Med. 26:1863-1867,1998.
  19. Ramirez J., B.R. Totapally, E. Hon, D. Torbati, M. Mangino, K. Hultquist, and J. Wolfsdorf, Oxygen carrying capacity during 10 hour hypercapnea in ventilated dogs, Crit. Care Med. 28:1918-1923, 2000.
  20. Mangino, M.J, and E. Garci, Mediators of Intestinal Ischemia Reperfusion Injur, Frontiers in Bioscience (review) on-line, 1998.
  21. Adams, J.A., M.J. Mangino, J. Bassuk, D. M. Inman, and M.A. Sackner, Noninvasive motion ventilation: A new approach to ventilatory suppor, J. Appl. Physiol. 89: 2439-2446, 2000.
  22. Adams, J.A., M.J. Mangino, J. Bassuk, , and M.A. Sackner, Hemodynamic effects of periodic Gz acceleration in meconium aspiration in pigs, J. Appl. Physiol. 89: 2447-2452, 2000.
  23. Bloch, K.E., J. Adams, J. Bassuk, M. Mangino, and M. A. Sackner, Noninvasive monitoring of cardiac output in human neonates and juvenile piglets by inductance cardiography (Thoracocardiography), J. Crit Care 17: 259-266, 2002.
  24. Mangino, M.J., J.A. Adams, J. Bassuk, P. Kurlanski, and M.A. Sackne, Regional blood flow during periodic Gz acceleration, Crit. Care Med. 10: 1983-1988, 2001
  25. Adams, J.A., M.J. Mangino, J. Bassuk, P. Kurlanski, and M.A. Sackner, Novel CPR with periodic Gz acceleration, Resuscitation 51: 55-62, 2001.
  26. Carey, H.V., J.H. Southard, and M.J. Mangino, Changes in gut function during hibernation: Implications for bowel transplantation and surgery, Gut 49:459-461, 2001.
  27. Compagnon, P., H. Wang, S. Lindell, M. Ametani, M. Mangino, A. D’Alessanro, and S. Southard ,Brain death does not affect hepatic allograft function and survival after orthotopic transplantation in a canine model, Transplantation 73: 1218-1227, 2002.
  28. Compagnon, P., H. Wang, J. Southard, and M. J. Mangin, Ischemic preconditioning in a rodent hepatocyte model of liver hypothermic preservation injur, Cryobiology 44: 269-278, 2002.
  29. Kosieradzki, M., Ametani, J.H. Southard, and M.J. Mangin, Is Ischemic preconditioning of the kidney clinically relevant, Surgery 133:81-90, 2003
  30. Mangino M.J., Kosieradzki, M., B. Gilligan, H. Woo, and J. H. Southard, The effects of donor brain death on renal function and arachidonic acid metabolism in a large animal model of hypothermic preservation injury, Transplantation 75(10): 1640-1647, 2003
  31. Mangino M.J., Ametani, M., Szabo, C, and Southard, J.H, Poly (ADP-Ribose) Polymerase and Renal Hypothermic Preservation Injur, Am. J. Physiol. 286: F838-847, 2004
  32. Gilligan, B., Kosieradski, M., Woo, H., Southard, J.H., and Mangino, M.J, Prolonged hypothermia causes primary non-function in preserved canine renal allografts due to humoral rejection, Am. J. Transplant 4:(8) 1266-1273, 2004
  33. Knes, J.M., Hansen, T.N., Gilligan, B., Woo, H., Mangino, M., Haworth, R, and Southard, J, Loss of endothelium-dependent relaxation in abdominal aorta preserved in a co-storage system, Transplant. Int. 17:699-706, 2005
  34. Lindell, S.L., Klahn, S. L., Piazza, T.M., Southard, J.H., Mangino, M.J., and H.V. Carey, Natural resistance to liver cold ischemia-reperfusion injury associated with the hibernatingPhenotype, Am. J. Physiol. 288:G473-80, 2005
  35. Lindell, S.L., Compagnon, P., Mangino, M.J., and Southard, J.H, UW Solution for Hypothermic Machine Perfusion of Warm Ischemic Kidneys, Transplantation 79:1358-1361, 2005
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