Prof. Hong-Shuo Sun
University of Toronto, Canada
Associate Professor
2004 Ph.D., Physiology and Neuroscience, University of Calgary, Canada
1990 M.Sc., Pharmacology and Pharmaceutical Sciences, University of Alberta, Canada
1982 M.D., Medicine, Sun Yat-Sen University of Medical Sciences, China
Publications (Selected)
  1. Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, MacDonald JF, Tymianski M. Suppression of Hippocampal TRPM7 Protein Prevents Delayed Neuronal Death in Brain Ischemia. Nature Neuroscience. 2009, 12(10): 1300-1307.
  2. Sun HS, French RJ, Feng ZP. A method for identifying viable and damaged neurons in adult mouse brain slices. Acta Histochemica. 2009, 111(6): 531-537.
  3. Olah ME, Jackson MF, Li H, Peres Y, Sun HS, Kiyonaka S, Mori Y, Tymianski M, MacDonald JF. Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol. 2009, 587(Pt5): 965-979.
  4. Betourne A, Bertholet AM, Labroue E, Halley H, Sun HS, Lorsignol A, Feng ZP, French RJ, Penicaud L, Lassalle JM, Frances B. Involvement of hippocampal CA3 KATP channels in contextual memory. Neuropharmacology. 2009, 56(3): 615-625.
  5. Sun HS, Doucette TA, Liu Y, Fang Y, Teves L, Aarts M, Ryan C, Bernard PB, Lau A, Forder JP, Salter MW, Wang YT, Tasker RA, Tymianski M. Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat. Stroke. 2008, 39(9): 2544-2553.
  6. Wu J, Sun Z, Sun HS, Wu J, Weisel RD, Keating A, Li ZH, Feng ZP, Li RK. Intravenously administered bone marrow cells migrate to damaged brain tissue and improves neural function in ischemia rats. Cell Transplantation. 2008, 16(10):993-1105.
  7. Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, MacDonald JF. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci USA. 2007, 104(41): 16323-8.
  8. Cui H, Hayashi A, Sun HS, Belmares MP, Cobey C, Phan T, Schweizer J, Salter MW, Wang YT, Tasker RA, Garman D, Rabinowitz J, Lu PS, Tymianski M. PDZ protein interactions underlying NMDA-receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007, 27(37): 9901-9915.
  9. Sun HS, Hui K, Lee D, Feng ZP. Zn sensitivity of high-voltage activated and low-voltage activated calcium channels. Biophys J. 2007, 93(4): 1175-1183.
  10. Gardzinski P, Lee DWK, Fei GH, Hui K, Huang GJ, Sun HS, Feng ZP. The role of synaptotagmin I C2A calcium binding domain in synaptic vesicle clustering during synapse formation. J Physiol. 2007, 581:75-90.
  11. Sun HS, Feng ZP, Barber P, Buchan A, French RJ. KATP channels protect cortical neurons from ischemic injury both in-vitro and in-vivo. Neuroscience. 2007, 144(4): 1509-1515.
  12. Fei G, Guo C. Sun HS, Lee D, Feng ZP. Chronic hypoxia stress induced differential modulation of HSP70 and presynaptic proteins. J Neurochem. 2007, 100(1): 50-61.
  13. Lau A, Arundine M, Sun HS, Jones M, Tymianski M. Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury. J Neurosci. 2006, 26(45):11540-11553.
  14. Sun HS, Feng ZP, Miki T, Seino S, French RJ. Enhanced neuronal damage after ischemic insults in mice lacking the Kir6.2 -containing ATP-sensitive K+ channels. J Neurophysiol. 2006, 95(4): 2590-2601.
  15. Hui K, Gardzinski P, Sun HS, Backx PH, Feng ZP. Permeable ions differentially affect gating kinetics and unitary conductance of L-type calcium channels. Biochem Biophys Res Communi. 2005, 338(2): 783-792.
  16. Zochodne DW, Sun HS, Cheng C, Eyer J. Accelerated diabetic neuropathy in axons without neurofilaments. Brain. 2004, 127(Pt10): 2193-2200.
  17. Liu S, Lau L, Wei J, Zhu D, Zou S, Sun HS, Fu Y, Liu F, Lu Y. Expression of Ca(2+)-permeable AMPA receptor channels primes cell death in transient forebrain ischemia. Neuron. 2004, 43:43-55
  18. Xu Q-G, Li X-Q, Kotecha SA, Cheng C, Sun HS, Zochodne DW. Insulin as an in vivo growth factor. Exp. Neuro. 2004, 188(1): 43-51.
  19. Xu Q-G, Cheng C, Sun H, Thomsen K, Zochodne DW. Local sensory ganglion ischemia induced by endothelin vasoconstriction: vulnerability of diabetic neurons and microvessels. Neuroscience. 2003, 122: 897-905.
  20. Zhu DY, Liu SH, Sun HS, Lu YM. Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J. Neurosci. 2003, 23(1): 223-229.
  21. Zochodne DW, Sun H, Li X. Evidence that nitric oxide and opioid containing interneurons innervate vessels in the dorsal horn of the spinal cord of rats. J. Physiol. 2001, 532(3): 749-758.
  22. Zochodne DW, Verge V, Cheng C, Sun H, Johnston J. Does diabetes target ganglion neurons? Progressive sensory neuron involvement in long term experimental diabetes. Brain. 2001, 124(Pt 11): 2319-34.
  23. Hoke A, Sun HS, Gordon T, Zochodne DW. Do denervated peripheral nerve trunks become ischemic: The impact of chronic denervation on vasa nervorum. Exp Neurol. 2001, 172(2): 398-406.
  24. Zochodne DW, Levy D, Zwiers H, Sun H, Rubin I, Cheng C, Lauritzen M. Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transacted peripheral nerves. Neuroscience. 1999, 91(4): 1515-1527.
  25. Zochodne DW, Misra M, Cheng C, Sun H. Inhibition of nitric oxide synthase enhances peripheral nerve regeneration in mice. Neurosci. Lett. 1997, 228: 71-74.
  26. Singhal A, Cheng C, Sun H, Zochodne DW. Near nerve local insulin treatment reverses conduction abnormalities in experimental diabetes. Brain Res. 1997, 763: 209-214.
  27. Schaafsma L, Sun H, Zochodne DW. Exogenous opioids influence the microcirculation of injured peripheral nerves. Am. J. Physiol. 1997, 272: H76-H82.
  28. Zochodne DW, Cheng C, Sun H. Diabetes increases sciatic nerve susceptibility to endothelin-induced ischemia. Diabetes. 1996, 45(5): 627-632.
  29. Whitelaw WA, Rimmer KP, Sun HS. Change in recruitment order of motor units in human parasternal intercostal muscles with sleep state. J. Appl. Physiol. 1993, 74(6): 2718-2723.
  30. Sun HS, Biggs DF. Afferent pathways of aortic baroreceptor fibers in guinea pigs. Acta Pharmacol. Sini. 1987, 8: 35 40.
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