Dr. Dean J. Burkin

University of Nevada School of Medicine,USA

Email: dburkin@medicine.nevada.edu

Qualifications

1994 Ph.D., Biochemistry , University of Colorado, USA

1986 B.Sc., Developmental Biology, Victoria University, New Zealand

Publications (Selected)

1. Boppart M D, Burkin DJ, Kaufman SJ (2011). Activation of AKT Signaling Promotes Cell Growth and Survival in alpha7 beta1 Integrin-Mediated Alleviation of Muscular Dystrophy. Biochimica et Biophysica Acta - Molecular Basis of Disease (In Press).
2. Xiong D, Heyman NS, Airey J, Ye L, Singer CA, Rawat S, Evans R, Burkin DJ, McCloskey DT, Britton F, Duan D and Hume JR (2010). Cardiac Specific, Inducible ClC-3 Gene Deletion Eliminates Native Volume-Sensitive Chloride Channels and Produces Myocardial Hypertrophy in Adult Mice.Journal of Molecular and Cellular Cardiology 48:211-219.
3. Welser JV, Rooney JE, Cohen NC, Gurpur PB, Singer CA, Evans R, Haines BA, and Burkin DJ (2009). Myotendinous Junction Defects and Reduced Force Transmission in Mice that Lack α7 Integrin and Utrophin. American Journal of Pathology 175:1545-1554.
4. Rooney RE, Gurpur PB and Burkin DJ (2009). Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences (USA) 106:7991-7996.
5. Xiong D, Wang G-X, Burkin DJ, Yamboliev IA, Miller L, Scowen P, Evans R, Ye L, Hatton WJ, Tian H, Keller PS, McCloskey DT, Duan D and Hume JR (2008). Cardiac specific overexpression of the human short ClC-3 chloride channel isoform in mice. Journal of Clinical and Experimental Pharmacology and Physiology 36:386-393.
6. Rooney J, Gurpur P, Yablonka-Reuveni Z and Burkin DJ (2009). Laminin-111 restores regenerative capacity in a mouse model for α7-integrin congenital myopathy. American Journal of Pathology 174:256-264.The paper was selected for a press release by the Editors of the American Journal of Pathology.
7. Gurpur P, Liu J, Burkin DJ and Kaufman SJ. Valproic Acid Activates the PI3K/Akt/mTOR Pathway in Muscle and Ameliorates Pathology in a Mouse Model of Duchenne Muscular Dystrophy (2009).American Journal of Pathology 174:256-264.
8. Boppart MD, Volker SE, Alexander N, Burkin DJ, and Kaufman SJ (2008). Exercise Promotes α7 Integrin Gene Transcription and Protection of Skeletal Muscle. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295:R1623-1630.
9. Liu J, Burkin DJ and Kaufman SJ (2008). Increasing α7β1 integrin promotes muscle cell proliferation, adhesion and resistance to apoptosis without changing gene expression. American,Journal of Physiology- Cell Physiology 294, C627-40.
10. Peat RA, Smith JM, Compton AG, Baker NL, Pace RA, Burkin DJ, Kaufman SJ, Lamandé SR and North KN (2008). Defining the aetiology of congenital muscular dystrophy. Neurology 71:312-321.
11. Welser JV, Lange NL, Flintoff-Dye NL and Burkin DJ (2007). Placental defects in α7 integrin null mice. Placenta 28, 1219-1228.
12. Welser JV, Lange N, Singer CA, Elorza M, Scowen P, Keef KD, Gerthoffer WT and Burkin DJ.(2007). Loss of the α7 integrin promotes ERK activation.