Dr. Arvind Chhabra

University of Connecticut Health Center, USA

Email: arvindac@yahoo.com

Qualifications

Ph.D., Biotechnology, Central Drug Research Institution

M.S., Biotechnology, Guru Nanak Dev University

B.S., Biology, Rohilkhand University

Publications(Selected)

1. Arvind Chhabra, Swagatam Ray, Nitya G Chakraborty and Bijay Mukherji. “ Activation Induced Cell Death (AICD) Of Human Melanoma Antigen Specific MHC class I TCR Engineered CD8 T Cells Is An Intrinsic Process That Involves JNK and p53”. The 10th Annual Meeting of Federation of Clinical immunology Society (FOCIS), Boston, MA, USA, June 24-27, 2010.
2. Arvind Chhabra, Swagatam Ray, Nitya G Chakraborty, Antoni Ribas, James S. Economou, Bijay Mukherji. “ MHC Class I-Restricted Human Melanoma Epitope Specific TCR Engineered Human CD4 T Cells Provide Effector Function, Proliferate upon Cognate Stimulation, Amplify CD8+ CTL Generation, and Mitigate inducible T Regulatory Cell (iTreg) Activities in Human Melanoma, in vitro.” The 9th Annual Meeting of Federation of Clinical immunology Society (FOCIS), San Francisco, CA, USA, June 11-14, 2009.
3. Swagatam Ray, Richard C. Koya, Begoña Comin-Anduix, Thinle Chodon, Jazirehi Ali, Nitya G Chakraborty, Antoni Ribas, James S. Economou, Bijay Mukherji, Arvind Chhabra. “Human CD4+ T Cells Engineered to express a MHC Class I-Restricted Human Melanoma Epitope Specific TCR exhibit all the effector functions of a bona fide CD8+ CTL, proliferate when stimulated, and help amplify the CTL burst size, in vitro”. Keystone Symposium on Mobilizing Cellular Immunity for Cancer Therapy,January, 11-16th, 2009, Snowbird, UT, USA.
4. Arvind Chhabra, Lilly Yang, Pin Wang, Nitya Chakraborty, David Dorsky, Antoni Ribas, Donald Kohn, David Baltimore, James Economou and Bijay Mukherji. “ Human Tumor Epitope Specific MHC Class, I-Restricted TCR Engineered CD4+ T Cells Function Just As Potent Cytolytic Effectors As CD8+ Cytolytic T Lymphocytes.” Keystone Symposium on Cell Death in Immune System, February 7-12th,2008, Backenridge, CO, USA.
5. Arvind Chhabra, Lilly Yang, Pin Wang, Nitya Chakraborty, Raja Das, Antoni Ribas, Donald Kohn,David Baltimore, James Economou and Bijay Mukherji. “MHC Class I-Restricted Tumor Epitope Specific TCR Engineered CD4+ T Cells Function as Helper and Cytolytic Effector Cells in Anti-Tumor,Immunity”. ISBTC-2007, Boston, MA, USA.
6. Arvind Chhabra, Nitya G. Chakraborty, Shikhar Mehrotra, David I. Dorsky and Bijay Mukherji. “Involvement of JNK, p53 and Bcl family in the Regulation of The AIF-Mediated and Caspase-Independent Activation Induced Cell Death of Melanoma Epitope Specific Human Cytotoxic T Lymphocytes” Keystone Symposium on Cell Death Pathways-2006, Montrey, CA.
7. Arvind Chhabra and Bijay Mukherji. “ Generation of Lenti-virus Mediated JNK and Apoptosis Inducing Factor (AIF) Knockout Cell Lines: Involvement of JNK & AIF in Fas and TNF-alpha mediated Cell Death Pathways”. ISBTC-2006.
8. Arvind Chhabra, Shikhar Mehrotra, Nitya G Chakraborty, David I Dorsky and Bijay Mukherji. “Mechanism of Caspase Independent Activation Induced Cell Death of Human Primary T Lymphocytes:Implications for Cancer Immunotherapy”. ISBTC-2005, Alexendria, VA.
9. Arvind Chhabra, Shikhar Mehrotra and Bijay Mukherji. “AIF-mediated and caspase-independent activation induced cell death of human primary cytolytic T lymphocytes.” Apoptosis Conference –2005, Trivendrum, Kerala, India.
10. Mehrotra S, Subhasis Chhatopadhyaya, Arvind Chhabra, Chakraborty NG, Mukherji B. “ Rescuing human melanoma associated antigen specific primary CTL from AICD”, ISBTC-2005, Alexendria, VA.
11. Arvind Chhabra, Mehrotra S, Chakraborty NG, Mukherji B, Dorsky DI. “Cross-presentation of a human tumor antigen delivered to dendritic cells by HSV-VP22- mediated protein translocation” ASCB-2004, San Francisco, CA.