Dr. Didier Merlin
Emory University, USA
Email: dmerlin@emory.edu
Qualifications
1994 Ph.D., Cell Biology, University Paris VII, France
1989 M.S., Cell Biology, University Paris VII, France
Publications (Selected)
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S.L. Lebeis, K.R. Powell, D. Merlin, M.A.
Sherman, D. Kalman. Interleukin-1 receptor signaling protects mice from lethal
intestinal damage caused by the attaching and effacing pathogen Citrobacter
rodentium. Infect Immun. 2009 Feb;77(2):604-14.
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P. Garg, M. Vijay-Kumar, L. Wang, A.T. Gewirtz,
D. Merlin, S.V. Sitaraman. Matrix metalloproteinase-9-mediated tissue injury
overrides the protective effect of matrix metalloproteinase-2 during colitis.
Am J Physiol Gastrointest Liver Physiol. 2009
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A.L. Theiss, M. Vijay-Kumar, T.S. Obertone,
D.P. Jones, J.M. Hansen, A.T. Gewirtz, D. Merlin, S.V. Sitaraman. Prohibitin Is
a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation
in Mice. Gastroenterology. 2009 Mar 25. [Epub ahead of print]
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Y. Yan, G. Dalmasso, H.T. Nguyen, T.S.
Obertone, S.V. Sitaraman, D. Merlin. Ste20-related proline/alanine-rich kinase
(SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal
barrier function. PLoS One. 2009;4(4):e5049.
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B.P. Chandrasekharan, V.L. Kolachala, G.
Dalmasso, D. Merlin, K. Ravid, S.V. Sitaraman, S. Srinivasan. Adenosine 2B
receptors (A2BAR) on enteric neurons regulate murine distal colonic motility.
FASEB J. 2009; 23(8):2727-34.
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Y. Yutao, V. Kolachala, G. Dalmasso, H.
Nguyen, S.V. Sitaraman, D. Merlin. Cytokine profile in DSS induced experimental
colitis. PLoS. One. 2009;4(6):e6073.
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H.T.T. Nguyen, G. Dalmasso, K. R. Powell,
Y. Yan, S. Bhatt, D. Kalman, S. Sitaraman, D. Merlin. Pathogenic bacteria
induce colonic PepT1 expression: an implication in host defense response.
Gastroenterology. 2009; 137(4):1435-47.
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S. Bhatt, A.N. Edwards, H.T. Nguyen, D.
Merlin, T. Romeo, D. Kalman D. The RNA binding protein CsrA is a pleiotropic
regulator of the locus of enterocyte effacement pathogenicity island of
enteropathogenic Escherichia coli. Infect Immun. 2009; 77(9):3552-68.
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A.L. Theiss, A.K. Jenkins, N.I. Okoro,
J.M. Klapproth, D. Merlin, S.V. Sitaraman. Prohibitin inhibits tumor necrosis
factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel
mechanism of decreasing importin alpha3 expression. Mol Biol Cell. 2009;
20(20):4412-23.
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H.T. Nguyen, G. Dalmasso, Y. Yan, H.
Laroui, S. Dahan, L. Mayer, S.V. Sitaraman, D. Merlin. MicroRNA-7 modulates
CD98 expression during intestinal epithelial cell differentiation. J Biol Chem.
2010; 285:1479-89.
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P. Garg, D. Sarma, S. Jeppsson, NR. Patel,
AT. Gewirtz, D. Merlin, S.V. Sitaraman. Matrix metalloproteinase-9 functions as
a tumor suppressor in colitis-associated cancer. Cancer Res. 2010;
70(2):792-801.
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H. Laroui, G. Dalmasso, H. Nguyen, Y. Yan,
SV. Sitaraman, D. Merlin. Drug-loaded nanoparticles targeted to the colon with
polysaccharide hydrogel reduce colitis in a mouse model. Gastroenterology.
2010; 138(3):843-53.
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Kolachala VL, Wang L, Obertone TS, Prasad
M, Yan Y, Dalmasso G, Gewirtz A, Merlin D, Sitaraman SV. Adenosine 2B receptor
expression is post-transcriptionally regulated by microRNA. J Biol Chem. 2010
Apr 13. [Epub ahead of print]
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G. Dalmasso, H. Nguyen, L.
Charrier-Hisamuddin, Y. Yan, H. Laroui, S. Sitaraman, D. Merlin. PepT1 mediates
transport of the bacterial peptidoglycan pro-inflammatory tripeptide
L-Ala-γ-D-Glu-meso-DAP in intestinal epithelial cells. 2010. Am. J. Physiol,
Gastrointest Liver Physiol. In Press.