Prof. Åke Sjöholm

Karolinska Institute, Sweden

Email: ake.sjoholm@sodersjukhuset.se

Qualifications

1991 Ph.D., Uppsala University, Sweden

1988 M.D., Uppsala University, Sweden

1984 M.B., Uppsala University, Sweden

Publications(Selected)

1. Welsh N, Sjöholm Å, Welsh M, Swenne I, Berggren PO, Rorsman P, Hellerström C.Ontogeny of differentiation, growth and function of the pancreatic β-cell. In: Diabetes 1988 (Larkins R, Zimmet P, Chisholm D, Eds). Elsevier, 1989, pp. 383-6
2. Hellerström C, Eizirik D, Welsh N, Sjöholm Å, Jansson L, Svensson C, Strandell E, Korsgren O, Li ZQ, Andersson A, Welsh M, Sandler S. New perspectives on the structure and function of the normal and diabetic β-cell. Ups J Med Sci 1991;96:1-16
3. Hellerström C, Sjöholm Å, Swenne I. Effects of growth hormone and related growth factors on the DNA replication and insulin production of pancreatic islet β-cells. Acta Paediatr Scand 1991;Suppl 377:55-62
4. Sjöholm Å. Intracellular signal transduction pathways that control pancreatic β-cell proliferation. FEBS Lett 1992;311:85-90
5. Sjöholm Å. Role of polyamines in the regulation of proliferation and hormone production by insulin-secreting cells. Am J Physiol 1993;264:C501-18
6. Berggren PO, Arkhammar P, Islam Md S, Juntti-Berggren L, Khan A, Kindmark H, Köhler M, Larsson K, Larsson O, Nilsson T, Sjöholm Å, Szecowska J, Zhang Q. Regulation of cytoplasmic free Ca2+ in insulin-secreting cells. In: New Concepts in the Pathogenesis of NIDDM-2nd Toronto-Stockholm Symposium on Perspectives in Diabetes Research (Östenson CG, Efendic´ S, Vranic M, Eds). Adv Exp Med Biol 1993;334:24-45
7. Sjöholm Å. Diabetes mellitus and impaired pancreatic β-cell proliferation. J Internal Med 1996;239:211-20
8. Sjöholm Å. Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets. Endocrine 1998;9:1-13
9. Sjöholm Å. Aspects of the involvement of interleukin-1 and nitric oxide in the pathogenesis of insulin-dependent diabetes mellitus. Cell Death Diff 1998;5:461-8
10. Sjöholm Å, Efendic´ S. Neurohormonal regulation of the insulin stimulus-secretion coupling in pancreatic islets. Exp Clin Endocrinol 2001;109:S109-21
11. Sjöholm Å. ALLHAT: A critical assessment. Blood Pressure 2004:13:75-9
12. Sjöholm Å, Nyström T. Endothelial inflammation in insulin resistance. Lancet 2005;365:610-2
13. Sjöholm Å, Nyström T. Inflammation and the etiology of type 2 diabetes. Diabetes Metab Res Rev 2006;22:4-10
14. Ortsäter H, Sjöholm Å. At the cutting edge: A busy cell – Endoplasmic reticulum stress in the pancreatic β-cell. Mol Cell Endocrinol 2007;277:1-5
15. Zhang F, Sjöholm Å, Zhang Q. Growth hormone signaling in pancreatic β-cells – Calcium handling regulated by growth hormone. Mol Cell Endocrinol 2009;297:50-7
16. Sjöholm Å. Impact of glucagon-like peptide-1 on endothelial function. Diabet Obes Metab 2009;11 (Suppl 3):1–7