Dr. Robert Paul Coppes

Department of Radiation Oncology

University of Groningen, Netherlands

Email: r.p.coppes@med.umcg.nl

Qualifications

1993 Ph.D., Faculty of Mathematics and Natural Sciences, University of Groningen

1988 M.Sc., Neuropharmacology and Neurophysiology, behavioural physiology, University of Groningen

Publications (Selected)

1. Pringle S, Nanduri LSY, van der Zwaag M, van Os RP, Coppes RP. Isolation of mouse salivary gland stem cells from salispheres. Journal of Visualized Experiments. 2010 http://www.jove.com/index/details.stp?id=2484, doi: 10.3791/2484 Invited article
2. Coppes RP, Lombaert IMA. Is stem cell therapy a reasonable approach? In: Dry Mouth, The malevolent symptom: A clinical guide. Sreebny LM and Vissink A eds. Wiley-Blackwell Iowa 2010.
3. Vissink A, Mitchell JB, Baum BJ, Limesand KH, Beier-Jensen S, Fox PC, Elting LS, Langendijk JA, Coppes RP and Reyland ME. Clinical management of salivary gland hypofunction and xerostomia in head and neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys 2010; 78 (4): 983-991.
4. Coppes R.P. Stokman M. Stem cells and the repair of radiation-induced salivary gland damage. Oral Dis. 2010 Aug 26. [Epub ahead of print] Invited Review
5. Niemantsverdriet M, de Jong E, Langendijk JA, Kampinga HH, Coppes RP. Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53. Radiother Oncol. 2010; 97(1):33-5
6. Ghobadi G, Hogeweg LE, Faber H, Tukker WGJ, Schippers JM, Brandenburg S, Langendijk JA, Coppes RP, van Luijk P. Quantifying local radiation-induced lung damage from computed tomography. Int J Radiat Oncol Biol Phys 2010; 76(2):548-56
7. Feng J, van der Zwaag M, Stokman MA, van Os R, Coppes RP. Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiother Oncol 2009; 92, 466-471.
8. van Luijk P, Faber H, Schippers JM, Brandenburg S, Langendijk JA, Meertens H, Coppes RP. Bath and shower effects in the rat parotid gland explain increased relative risk of parotid gland dysfunction after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2009 July 15;74(4):1002-5.
9. Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y. Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys 2009 August 1;74(5):1580-91.
10. Coppes RP, van der GA, Lombaert IM. Stem cell therapy to reduce radiation-induced normal tissue damage. Semin Radiat Oncol 2009 April;19(2):112-21. Invited Review
11. Burlage FR, Faber H, Kampinga HH, Langendijk JA, Vissink A, Coppes RP. Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands. Radiother Oncol 2009 February;90(2):253-6.
12. Coppes RP, Lombaert IMA. Regeneratie van door straling beschadigde speekselklieren: is stamceltherapie een optie? In: Het Tandheelkundig Jaar 2009, 78-87. Baat C, Aps JKM, Brands WG, Duyk J, Jacobs R, Vissink A, van Welsenes W. Eds Bohn Stafleu van Loghum. Houten 2009. ISBN 978-90-313-52760.
13. Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP. Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation. Clin Cancer Res 2008 December 1;14(23):7741-50.
14. Feng J, Coppes RP. Can we rescue salivary gland function after irradiation? ScientificWorldJournal 2008;8:959-62.
15. Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP. Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool. Stem Cells 2008 October;26(10):2595-601.
16. Karliczek A, Zeebregts CJ, Benaron DA, Coppes RP, Wiggers T, van Dam GM. Preoperative irradiation with 5 x 5 Gy in a murine isolated colon loop model does not cause anastomotic weakening after colon resection. Int J Colorectal Dis 2008 November;23(11):1115-24.
17. Lombaert IM, Brunsting JF, Wierenga PK, Faber H, Stokman MA, Kok T, Visser WH, Kampinga HH, de Haan G, Coppes RP. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One 2008;3(4):e2063.
18. Burlage FR, Roesink JM, Faber H, Vissink A, Langendijk JA, Kampinga HH, Coppes RP. Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment. Radiother Oncol 2008 March;86(3):347-53.
19. Burlage FR, Roesink JM, Kampinga HH, Coppes RP, Terhaard C, Langendijk JA, van Luijk P, Stokman MA, Vissink A. Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study. Int J Radiat Oncol Biol Phys 2008 January 1;70(1):14-22.
20. van Luijk P, Faber H, Meertens H, Schippers JM, Langendijk JA, Brandenburg S, Kampinga HH, Coppes RP. The impact of heart irradiation on dose-volume effects in the rat lung. Int J Radiat Oncol Biol Phys 2007 October 1;69(2):552-9.