Dr. Yigang Wang
Department of Pathology and Laboratory Medicine
Universityof Cincinnati, USA
Email:yi-gang.wang@uc.edu
Qualifications
1997 Ph.D., Tokyo Medical and Dental University, Japan
1983 M.D., Qinghai Medical College, China
Publications (Selected)
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Fryer RM, Hsu AK,
Wang Y, Henry M, Eells J, Gross GJ. PKC- inhibition does not block
preconditioning-induced protection in mitochondrial ATP synthesis and infarct
size reduction in rats. Basic Res Cardiol. 2002;97:47-54.
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Wang Y, Wang XH,
Sunamori M. Effect of histidine in the nondepolarizing cardioplegic solution on
myocardial function and biochemistry. Chinese Journal of Pathophysiology.
2002;18(13):1690-1691.
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Wang Y and Ashraf
M. Effect of ischemic preconditioning on Na+/H+ exchanger isoform-1 knockout
mice. Chinese Journal of Pathophysiology. 2002;18(13):1655-1656.
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Kudo M, Wang Y, Xu
M, Ayub A, Ashraf M. Adenosine A1 receptor mediates late preconditioning via
activation of PKC-d signaling pathway. Am J Physiol Heart Circ Physiol 2002;283:H296-H301.
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Wang Y, Meyer W.
J, Shull E G, Ashraf M. Mice With a Null Mutation in the NHE1 Na+/H+ Exchanger
are Resistant to Cardiac Ischemia-Reperfusion Injury. Circ Res.
2003;93:776-782.
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Wang Y, Ahmad N,
Kudo M, Ashraf M. Contribution of Akt and Endothelial Nitric Oxide Synthase to
Diazoxide-Induced Late Preconditioning. Am J Physiol Heart Circ Physiol.
2004;287(3):H1125-31.
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Wang Y, Ahmad N,
Wani MA, Ashraf M. Hepatocyte Growth Factor Prevents Ventricular Remodeling and
Dysfunction in Mice via Akt Pathway and Angiogenesis. J Mole Cell Cardial. J
Mol Cell Cardiol. 2004;37(5):1041-52.
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Wang Y, Haider HK,
Ahmad N, Ashraf M. KATP openers and mechanisms by which these agents produce
acute and delayed cardioprotection. Vascul Pharmacol. 2005;42(5-6):253-64.
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Wang Y, Haider HK,
Ahmad N, Xu, M, Ge R, Ashraf M. Combining pharmacological mobilization with
intramyocardial delivery of bone marrow cells over-expressing VEGF is more
effective for cardiac repair, JMCC. 2006;40:736-745.
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Wang Y, Haider
HKH, Ahmad N, Zhang D, Ashraf M. Evidence for Ischemia Induced Host Derived
Bone Marrow Cell Mobilization into Cardiac Allografts. J Mol Cell Cardiol.
2006;41(3):478-487.
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Fan GC, Yuan Q,
Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG. Small
heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling
through apoptosis signal-regulating kinase 1. Circ Res. 2006;99:1233-42.
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Wang Y, Ahmad N,
Wang B, Ashraf M. Chronic preconditioning: a novel approach for cardiac
protection. Am J Physiol Heart Circ Physiol. 2007;292:H2300-H2305.
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Pasha Z, Wang Y,
Sheikh R, Zhang D, Zhao T, Ashraf M. Preconditioning enhances cell survival and
differentiation of stem cells during transplantation in infarcted myocardium.
Cardiovasc Res. 2007. In press. Available online.
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Zhang D, Fan GC,
Zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M, Wang Y*. Over-expression of
CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted
myocardium. J Mol Cell Cardiol. JMCC. 2008;44(2):281-92.
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Zhao T, Zhang D,
Millard RW, Ashraf M, Wang Y. Stem cell homing and angiomyogenesis in
transplanted hearts are enhanced by combined intramyocardial SDF-1a delivery and
endogenous cytokine signaling. AJP. 2009;296(4):H976-86. PMID: 19181961
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Millard R, Wang Y.
Milieu Inte´rieur: The search for myocardial arteriogenic signals. Journal of
the American College of Cardiology (J Am Coll Cardiol). 2009;53(23):2148-9.
PMID: 19497440
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Ahmad N, Wang Y,
Ali AK, Ashraf M. Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces
sustained cardioprotection against lethal ischemic injury. Am J Physiol Heart
Circ Physiol. 2009; 297:H387-91. PMID: 19429825
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Jagatheesan G,
Rajan S, Schulz EM, Ahmed RP, Petrashevskaya NN, Schwartz A, Boivin GP, Arteaga
GM, Wang T, Wang Y, Ashraf M, Liggett SB, Lorenz JN, Solaro RJ, Wieczorek DF.
An internal domain of {beta}-tropomyosin increases myofilament calcium
sensitivity. Am J Physiol Heart Circ Physiol. 2009;297:H181-90. PMID: 19429821
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Wang X, Zingarelli
B, Connor MO, Zhang P, Adeyemo A, Kranias1 EG, Wang Y, Fan GC. Overexpression
of Hsp20 Prevents Endotoxin-Induced Myocardial Dysfunction and Apoptosis via
Inhibition of NF-κB Activation. JMCC. 2009;47(3):382-90. PMID: 19501592
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Wang X, Zhao T,
Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y*, Fan GC. Hsp20-Engineered
Mesenchymal Stem Cells Are Resistant to Oxidative Stress via Enhanced
Activation of Akt and Increased Secretion of Growth Factors. Stem Cells. 2009
;27(12):3021-3031. PMID: 19816949. (Co-correspondence)
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Huang W, Zhang D,
Millard R, Wang T, Zhao T,
Fan GC, Ashraf A, Xu M, Ashraf M, Wang Y. Gene manipulated peritoneal cell patch repairs infarcted myocardium.
JMCC. 2010;48(4):702-12. PMID: 19913551.
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Wang Y, Zhang D,
Ashraf M, Zhao T, Huang W, Ashraf A, Ambikaipakan Balasubramaniam A. Combining
neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial
infarction. AJP. 2010;298(1):H275-86. PMID: 19897711.
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Zhang D, Huang W,
Dai B, Zhao T, Ashraf A, Millard RW, Ashraf M, Wang Y. Genetic manipulated
progenitor cell sheet with diprotin A improves myocardial function and repair
of infarcted hearts. Am J Physiol Heart Circ Physiol. 2010
299(5):H1339-47. PMID: 20802132.
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Huang W, Wang T,
Zhang D, Zhao T, Dai B, Ashraf A, Wang X, Xu M, Millard RW, Fan GC, Ashraf M,
Yu XY, Wang Y. Mesenchymal Stem Cells Overexpressing CXCR4 Attenuate Remodeling
of Post-myocardial Infarction by Releasing Matrix Metalloproteinase-9. Stem Cell
and Development. Stem Cells Dev. 2011 Jun 14. [Epub ahead of print]
PMID:21671800.
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Dai B, Huang W, Xu
M, Millard RW, Gao MH, Hammond HK, Menick DR, Ashraf M, Wang Y. Reduced
Collagen Deposition in Infarcted Myocardium Facilitates Induced Pluripotent Stem
Cells (iPSC) Engraftment and Angiomyogenesis for Improvement of Left
Ventricular Function. Journal of the American College of Cardiology (JACC).
2011;58(20):2118-27. (With Editorial Comment).