Prof. Francesco Filippini

University of Padua, Italy

Email: francesco.filippini@unipd.it

Qualifications

2005, Associate Professor (Molecular Biology and Bioinformatics), Faculty of Sciences, University of Padua

1995, Assistant Professor (Molecular Biology), Faculty of Sciences, University of Padua

1993, Ph.D., Molecular and Cellular Genetics, University of Naples

1988, M.S., Biological Sciences, University of Naples

Publications(Selected)

1. Vivona, S., Liu, C.W., Strop, P., Rossi, V., Filippini, F., Brunger, A.T. The longin SNARE VAMP7/TI-VAMP adopts a closed conformation. J Biol Chem. 2010 Jun 4; 285(23):17965-73.
2. Strazzullo, M., Rossetti, C., Fusco, G., Campanile, C., Vecchio, D., Campanile, G., Perucatti, A., Di Meo, G.P., Filippini, F., Eggen, A., Ferrara, L., D'Esposito, M. Genomic characterization and chromosomal mapping of 5 river buffalo skeletal muscle differentiation master genes. Cytogenet Genome Res. 2010 Jun; 128(4):221-7.
3. Vedovato, M., Rossi, V., Dacks, J.B., Filippini, F. Comparative analysis of plant genomes allows the definition of the "Phytolongins": a novel non-SNARE longin domain protein family. BMC Genomics. 2009 Nov 4; 10:510.
4. Vivona, S., Gardy, J.L., Ramachandran, S., Brinkman, F.S., Raghava, G.P., Flower, D.R., Filippini, F. Computer-aided biotechnology: from immuno-informatics to reverse vaccinology. Trends Biotechnol. 2008 Apr; 26(4):190-200.
5. Carpi, A., Rossi, V., Filippini, F. Tyrosine Phosphorylation in Plants - Emerging Evidence. In: Various Authors. Plant Proteomics: Technologies, Strategies and Applications - Ganesh K. Agrawal and Randeep Rakwal Editors, p. 499-512, WILEY Publisher, 2008. ISBN/ISSN: 978-0-470-06976-9
6. Vivona, S., Bernante, F., Filippini, F. NERVE: new enhanced reverse vaccinologyenvironment. BMC Biotechnol. 2006 Jul 18; 6:35.
7. Rossi, V., Banfield, D.K., Vacca, M., Dietrich, L.E., Ungermann, C., D'Esposito, M., Galli, T., Filippini, F. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Trends Biochem Sci. 2004 Dec; 29(12):682-8.
8. Rossi, V., Picco, R., Vacca, M., D'Esposito, M., D'Urso, M., Galli, T., Filippini, F. VAMP subfamilies identified by specific R-SNARE motifs. Biol Cell. 2004 May; 96(4):251-6.
9. Martinez-Arca, S., Rudge, R., Vacca, M., Raposo, G., Camonis, J., Proux-Gillardeaux, V., Daviet, L., Formstecher, E., Hamburger, A., Filippini, F., D'Esposito, M., Galli, T. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):9011-6.
10. Carpi, A., Di Maira, G., Vedovato, M., Rossi, V., Naccari, T., Floriduz, M., Terzi, M., Filippini, F. Comparative proteome bioinformatics: identification of a whole complement of putative protein tyrosine kinases in the model flowering plant Arabidopsis thaliana. Proteomics. 2002 Nov; 2(11):1494-503.
11. Miano, M.G., Testa, F., Filippini, F., Trujillo, M., Conte, I., Lanzara, C., Millán, J.M., De Bernardo, C., Grammatico, B., Mangino, M., Torrente, I., Carrozzo, R., Simonelli, F., Rinaldi, E., Ventruto, V., D'Urso, M., Ayuso, C., Ciccodicola, A. Identification of novel RP2 mutations in a subset of X-linked retinitis pigmentosa families and prediction of new domains. Hum Mutat. 2001 Aug; 18(2):109-19.
12. Vacca, M., Filippini, F., Budillon, A., Rossi, V., Della Ragione, F., De Bonis, M.L., Mercadante, G., Manzati, E., Gualandi, F., Bigoni, S., Trabanelli, C., Pini, G., Calzolari, E., Ferlini, A., Meloni, I., Hayek, G., Zappella, M., Renieri, A., D'Urso, M., D'Esposito, M., Macdonald, F., Kerr, A., Dhanjal, S., Hulten, M. MECP2 gene mutation analysis in the British and Italian Rett Syndrome patients: hot spot map of the most recurrent mutations and bioinformatic analysis of a new MECP2 conserved region. Brain Dev. 2001 Dec; 23 Suppl 1:S246-50.
13. Filippini, F., Rossi, V., Galli, T., Budillon, A., D'Urso, M., D'Esposito, M. Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. Trends Biochem Sci. 2001 Jul; 26(7):407-9.
14. Vacca, M., Filippini, F., Budillon, A., Rossi, V., Mercadante, G., Manzati, E., Gualandi, F., Bigoni, S., Trabanelli, C., Pini, G., Calzolari, E., Ferlini, A., Meloni, I., Hayek, G., Zappella, M., Renieri, A., D'Urso, M., D'Esposito, M., MacDonald, F., Kerr, A., Dhanjal, S., Hulten, M. Mutation analysis of the MECP2 gene in British and Italian Rett syndrome females. J Mol Med. 2001; 78(11):648-55.
15. Gasparian, M., Pusterla, M., Baldan, B., Downey, P.M., Rossetto, O., de Laureto, P.P., Filippini, F., Terzi, M., Lo Schiavo, F. Identification and characterization of an 18-kilodalton, VAMP-like protein in suspension-cultured carrot cells. Plant Physiol. 2000 Jan; 122(1):25-34.
16. Barizza, E., Lo Schiavo, F., Terzi, M., Filippini, F. Evidence suggesting protein tyrosine phosphorylation in plants depends on the developmental conditions. FEBS Lett. 1999 Mar 26; 447(2-3):191-4.
17. Baldan, B., Guzzo, F., Filippini, F., Gasparian, M., Lo Schiavo, F., Vitale, A., de Vries, S.C., Mariani, P., Terzi, M. The secretory nature of the lesion of carrot cell variant ts11, rescuable by endochitinase. Planta. 1997; 203(3):381-9.
18. Filippini, F., Rossi, V., Marin, O., Trovato, M., Costantino, P., Downey, P.M., Lo Schiavo, F., Terzi, M. A plant oncogene as a phosphatase. Nature. 1996 Feb 8; 379(6565):499-500.