Prof. Yuin-Han
Jonathan Loh
Institute of Molecular and Cell Biology (IMCB)
Children's Hospital Boston, USA
Email: yhloh@imcb.a-star.edu.sg
Qualifications
2008-2011 Post-doctoral Fellowship, Stem cell Biology, Harvard Medical School
2003-2008 Ph.D., Biological Chemistry and Molecular Pharmacology, National University of Singapore
1999-2002 B.Sc., Cellular and Molecular Biology, National University of Singapore
Publications (Selected)
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Loh, Y. H., Wu, Q.,
Chew, J. L., Vega, V. B., Zhang, W., Chen, X., Bourque, G., George, J., Leong,
B., Liu, J., Wong, K. Y., Sung, K. W., Lee, C. W., Zhao, X. D., Chiu, K. P.,
Lipovich, L., Kuznetsov, V. A., Robson, P., Stanton, L. W., Wei, C. L., Ruan, Y.,
Lim, B., and Ng, H. H. (2006). The Oct4 and Nanog transcription network
regulates pluripotency in mouse embryonic stem cells. Nature Genetics 38,
431–440. Epub 2006 Mar 5.
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Agarwal, S., Loh,
Y. H., McLoughlin, E. M., Huang, J., Park, I. H., Miller, J. D., Huo, H., Okuka,
M., dos Reis, R. M., Loewer, S., Ng, H. H. Keefe, D. L., Goldman, F. D.,
Klingelhutz, A. J., Liu, L., Daley, G. Q. (2010) Telomere elongation in
dyskeratosis congenital induced pluripotent stem cells. Nature464, 292-296. Epub
2010 Feb 17.
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Loh, Y. H.,
Hartung, O., Li, Hu., Guo C., Sahalie, J. M., Manos P. D., Urbach, A., Heffner
G. C., Grskovic, M., Vigneault, F., Lensch M. W, Park I. H., Agarwal, S., Church,
G. M., Collins, J. J., Irion, S., Daley, G. Q. (2010). Reprogramming of T Cells
from Human Peripheral Blood. Cell Stem Cell 7, 15-19.
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Loh, Y. H., Zhang,
W., Chen, X., George, J., Ng, H. H. (2007). Jmjd1a and Jmjd2c histone H3 lysine
9 demethylases regulate self-renewal in embryonic stem cells. Genes and
Development 21, 2545-2557.
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Loh, Y. H., Agarwal,
S., Park, I. H., Urbach, A., Park, I. H., Heffner, G.C., Kim, K., Miller, J. D.,
Ng, K., Daley G.Q. (2009). Generation of induced pluripotent stem cells from
human blood. Blood. 113, 5476-5479. Epub 2009 Mar 18.
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Jiang, J., Chan,
Y. S., Loh, Y. H.*, Cai, J., Tong, G. Q., Lim, C. A., Robson, P., Zhong, S., Ng,
H. H. (2008). A core Klf circuitry that regulates self-renewal of embryonic stem
cells.Nature Cell Biology 10, 353-360. Epub 2008 Feb 10.
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Warren, L., Manos,
P. D., Ahfeldt, T., Loh, Y. H.*, Lau, F., Ebina, W., Smith, Z. D., Li, H., Collins,
J. J., Meissner, A., Daley, GQ., Brack, A. S., Cowan, C., Schlaeger, T. M., Rossi,
D.J. (2010). Highly efficient reprogramming to pluripotency and directed
differentiation using synthetic mRNA. Cell Stem Cell 7(5):618-30. Epub 2010 Sep
30.
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Loh, Y. H.*, Ng,
J. H, Ng, H. H. (2008). Molecular framework underlying pluripotency Cell Cycle 7: 7,
1-8. Invited Review.
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Loewer, S.,
Cabili, M., Guttman, M., Loh, Y. H., Thomas, K., Park, I. H., Garber, M., Curran,
M., Manos, P. D., Agarwal, S., Onder, T., Datta, S., Lander, E. S., Schlaeger,
T. M., Daley, GQ., Rinn, J. L.(2010). Large intergenic non-coding RNAs as novel
modulators of reprogramming. Nature Genetics42(12):1113-7. Epub 2010 Nov 7. Paper was featured in Preview by Huck-Hui Ng (Dec 2010)Nature Genetics 42(12).
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Chan E. M.,
Ratanasirintrawoot S., Park I. H., Manos P. D., Loh Y. H., Huo H., Miller J. D.,
Hartung O., Rho J., Ince T. A., Daley G. Q., Schlaeger T.M. (2009) Live cell
imaging distinguishes bona fide human iPS cells from partially reprogrammed
cells. Nature Biotechnology. 27, 1033-1037. Epub 2009 Oct 11.
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Chen, X. Xu, H.,
Yuan, P., Fang, F., Huss, M., Vega, V., Wong, E., Orlov, Y., Zhang, W., Jiang,
J., Loh, Y. H., Yeo, H. C., Yeo, Z. H., Narang, V., Govindarajan, K.R., Leong, B.,
Shahab, A., Ruan, Y., Bourque, G., Sung, W.K., Clarke, N., Wei, C.L., Ng, H.H.
(2008) Integration of external signaling pathways with the core transcriptional
network in embryonic stem cells. Cell 13; 133(6):1106-17.
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Chew, J. L., Loh,
Y. H.*, Zhang, W., Chen, X., Tam, W. L., Yeap, L. S., Li, P., Ang, Y. S., Lim, B.,
Robson, P., and Ng, H. H (2005). Reciprocal transcriptional regulation
of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Molecular and
Cellular Biology 25, 6031-6046.
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Lim, L. S., Loh,
Y. H.*, Zhang, W., Li, Y., Chen, X., Wang, Y., Bakre, M., Ng, H. H., and Stanton,
L. W. (2007). Zic3 Is Required for Maintenance of Pluripotency in Embryonic Stem
Cells. Molecular Biology of the Cell 18, 1348-1358. Epub 2007 Jan 31.
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Feng, B., Jiang,
J., Kraus, P., Ng, J.H., Heng, J.C., Chan, Y.S., Yaw, L.P., Zhang, W., Loh,
Y.H., Han, J., Vega, V.B., Cacheux-Rataboul, V., Lim, B., Lufkin, T., Ng, H.H.
(2009). Reprogramming of fibroblasts into induced pluripotent stem cells with
orphan nuclear receptor Esrrb. Nature Cell Biology. 11(2):197-203. Epub 2009 Jan
11.
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Yuan P., Han J.,
Guo G., Orlov Y. L., Huss M., Loh Y. H., Yaw L. P., Robson P., Lim B., Ng H.H. Eset
partners with Oct4 to restrict extraembryonic trophoblast lineage potential in
embryonic stem cells. Genes and Development 23, 2507-2520.
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Ng, J. H., Heng,
J. C. D., Loh, Y. H.*, Ng, H. H. (2008) Epigenetic and Transcriptional regulation
of stem cells. Mutat Res. 1; 647(1-2):52-8. Epub 2008 Aug 20. Invited Review.
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Rodda, D.J., Chew,
J. L., Lim, L. H., Loh, Y. H., Wang, B., Ng, H. H., and Robson, P. (2005).
Transcriptional regulation of Nanogby OCT4 and SOX2. Journal of
Biological Chemistry 280, 24731–24737. Epub 2005 Apr 27.
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Wu, Q., Chen, X.,
Zhang, J., Loh, Y. H., Low, T. Y., Zhang, W., Zhang, W., Sze, S. K., Lim, B., and
Ng, H. H. (2006). Sall4 interacts with Nanog and co-occupies Nanog genomic sites
Gore, A., Li, Z., Fung, H. L., Young, J., Agarwal, S., Antosiewicz-Bourget, J.,
Canto, I., Israel, M., Kiskinis, E., Lee, J. H., Loh, Y. H., Manos P.D.,
Montserrat, N., Wilbert, M., Yu, J., Kirkness, E., Belmonte, J. C. I, Daley,
G. Q., Eggan, K., Rossi, D. J., Thomson, J., Goldstein, L. S. B., Zhang, K. (2010).
Somatic coding mutations in human induced pluripotent stem cells. Nature.
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Kim, K., Zhao, R.,
Doi, A., Ng, K., Unternaehrer, J., Cahan, P., Hongguang, H., Loh, Y. H., Aryee,
J. M., Feinberg, P. A., Daley, G. Q., Epigenetic memory in human induced
pluripotent stem cells. Nature Biotechnology.