Prof. Yi-Han Chen

Institute of Medical Genetics
Tongji University, China



1993-1996 Ph.D., School of Medicine, Shanghai Jiaotong University, China
1982-1987 M.D., School of Medicine, Nantong University, China

Publications (Selected)

  1. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou CP, Chen Z, Barhanin J, Huang W. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 2003; 299: 251-4. (Corresponding Author)
  2. Yang Y, Xia M, Jin Q, Bendahhou S, Shi J, Chen Y, Liang B, Lin J, Liu Y, Liu B, Zhou Q, Zhang D, Wang R, Ma N, Su X, Niu K, Pei Y, Xu W, Chen Z, Wan H, Cui J, Barhanin J, Chen Y. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet 2004; 75: 899-905. (Corresponding Author)
  3. Xia M, Jin Q, Bendahhou S, He Y, Larroque MM, Chen Y, Zhou Q, Yang Y, Liu Y, Liu B, Zhu Q, Zhou Y, Lin J, Liang B, Li L, Dong X, Pan Z, Wang R, Wan H, Qiu W, Xu W, Eurlings P, Barhanin J, Chen Y. A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun 2005; 332: 1012-9. (Corresponding Author)
  4. He Y, Xiao J, Yang Y, Zhou Q, Zhang Z, Pan Q, Liu Y, Chen Y. Stretch-induced alterations of human Kir2.1 channel currents. Biochem Biophys Res Commun 2006; 351: 462-627. (Corresponding Author)
  5. Yang Y, Liu Y, Dong X, Kuang Y, Lin J, Su X, Peng L, Jin Q, He Y, Liu B, Pan Z, Li L, Zhu Q, Lin X, Zhou Q, Pan Q, Eurlings PMH, Fei J, Wang Z, Chen YH. Human KCNQ1 S140G mutation is associated with atrioventricular blocks. Heart Rhythm 2007; 4: 611-8. (Corresponding Author)
  6. Volders PG, Zhu Q, Timmermans C, Eurlings PM, Su X, Arens YH, Li L, Jongbloed RJ, Xia M, Rodriguez LM, Chen YH. Mapping a Novel Locus for Familial Atrial Fibrillation on Chromosome 10p11-q21. Heart Rhythm 2007; 4: 469-675. (Corresponding Author)
  7. Chen YH, Chen H, Wu Y, Hu D. Cardiac Electrophysiology in China. Heart Rhythm 2007; 5: 862. (Corresponding Author)
  8. Pan Q, He Y, Zhang Z, Liu Y, Zhou Q, Li J, Li P, Liang L, Zhao C, Qi J, Peng L, Chen YH.Spatial heterogeneity of muscarinic type 2 receptors in the atrium. Int J Cardiol 2008; 127: 427-9. (Corresponding Author)
  9. Liang L, Pan Q, Liu Y, Chen H, Li J, Brugada R, Brugada P, Hong K, Perez GJ, Zhao C, Qi J, Zhang Y, Peng L, Li L, Chen YH. High sensitivity of the sheep pulmonary vein antrum to acetylcholine stimulation. J Appl Physiol 2008; 105: 293-8. (Corresponding Author)
  10. He Y, Pan Q, Li J, Chen H, Zhou Q, Hong K, Brugada R, Perez GJ, Brugada P, Chen YH. Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes. FEBS Letters 2008; 582: 2338-42. (Corresponding Author)
  11. Zhao C, Qi J, Liu X, Chen H, Li J, Li Y, Liang L, Zhang Y, Xiao J, Li L, Peng L, Xu J, Ma J, Yang Y, Wu X, Chen YH. Refractoriness of the Sheep Superior Vena Cava Myocardial Sleeve.Exp Biol Med2008; 233: 1441-7. (Corresponding Author)
  12. Li J, Xiao J, Liu Y, Zhang G, Zhang H, Liang D, Liu Y, Zhang Y, Hu Y, Yu Z, Yan B, Jiang B, Peng L, Zhou ZN, Chen YH. Mitochondrial benzodiazepine receptors mediate cardioprotection of estrogen against ischemic ventricular fibrillation. Pharmacol Res 2009; 60: 61-7. (Corresponding Author)
  13. Yang Y, Li J, Lin X, Yang Y, Hong K, Wang L, Liu J, Li L, Yan D, Liang D, Xiao J, Jin H, Wu J, Zhang Y, Chen YH. Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation.J Hum Genet2009; 54: 277-83. (Corresponding Author)
  14. Qi J, Xiao J, Zhang Y, Li J, Liu J, Li P, Liang L, Jiang B, Wen W, Zhao C, Liang D, Liu Y, Chen YH. Effects of Potassium Channel Blockers on Changes in Refractoriness of Atrial Cardiomyocytes Induced by Stretch.Exp Biol Med2009; 234: 779-84. (Corresponding Author)
  15. Pan Q, Xu W, Tang Y, Yang Y, Ma J, Zhang Z, Liu Y, Zhou Q, Peng L, Li P, Liang D, Chen H, Li J, Xiao J, Zhang J, Chen YH. Unique Histological Feature of Left Atrial Posterior Wall. J Int Med Res 2009; 37: 392-9. (Corresponding Author)
  16. Li J, Xu J, Xiao J, Zhang H, Liang D, Liu Y, Zhang Y, Liu Y, Wen W, Hu Y, Yu Z, Yan B, Jiang B, Zhou ZN, Chen YH. Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity.J Cell Mol Med. 2009 DOI: 10.111 1/j.1582-4934.2009.00949.x (Corresponding Author)
  17. Xiao JJ, Liang DD, Zhang H, Liu Y, Li FJ, Chen YH. 4’-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats. Exp Biol Med2010; 235: 478-86. (Corresponding Author)
  18. Li J, Xiao JJ, Liang DD, Zhang H, Zhang GF, Liu Y, Zhang YY, Liu Y, Yu Z, Yan B, Jiang B, Li F, Peng LY, Zhou ZN, Chen YH. Inhibition of mitochondrial translocator protein prevents atrial fibrillation. Eur J Pharmacol 2010; 632: 60-4. (Corresponding Author)
  19. Xiao JJ, Zhao H, Liang DD, Liu Y, Zhang H, Liu Y, Li J, Peng LY, Zhou ZN, Chen YH. Taxol, a Microtubule Stabilizer, Improves Cardiac Contractile Function During Ischemia in Vitro. Pharmacology 2010; 85: 301-10. (Corresponding Author)
  20. Pan Q, Ma J, Zhou Q, Li J, Tang Y, Liu Y, Yang Y, Xiao J, Peng L, Li P, Liang D, Zhang H, Chen YH. KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice. Mol Biol Rep2010; 37: 1329-33. (Corresponding Author)
  21. Xiao JJ, Liang DD, Zhao H, Liu Y, Zhang H, Lu XW, Liu Y, Li J, Peng LY, Chen YH. 2-Aminoethoxydiphenyl borate, a inositol 1,4,5-triphosphate receptor inhibitor, prevents atrial fibrillation.Exp Biol Med 2010; 235: 862-8. (Corresponding Author)
  22. Xiao JJ, Liang DD, Liu Y, Zhang H, Liu Y, Zhao H, Li J, Peng LY, Zhou ZN, Chen YH. Taxol, a Microtubule Stabiliser, Improves Cardiac Functional Recovery during Post-ischaemic Reperfusion in Rat in Vitro. Cardiovasc Ther 2010 DOI:10.1111/j.1755-5922.2010.00163x (Corresponding Author)
  23. Yang YZ, Yang YQ, Liang B, Liu JQ, Li J, Grunnet M, Olesen SP, Rasmussen HB, Ellinor PT, Gao LJ, Lin XP, Li L, Wang L, Xiao JJ, Liu Y, Liu Y, Zhang SL, Liang DD, Peng LY, Jespersen T, Chen YH. Identification of a Kir 3.4 mutation in congenital long QT syndrome. Am J Hum Genet 2010; 86: 872-80. (Corresponding Author)
  24. Xiao JJ, Cao HM, Liang DD, Liu Y, Zhang H, Zhao H, Liu Y, Li J, Yan B, Peng LY, Zhou ZN, Chen YH. Taxol, a microtubule stabilizer, prevents ischemic ventricular arrhythmias in rats. J Cell Mol Med 2010 DOI:10.1111/ j.1582 – 493 4. 20 10. 01106. X (Corresponding Author)
  25. Li J, Yan B, Huo ZX, Liu Y, Xu JH, Sun YF, Liu Y, Liang DD, Peng LY, Zhang YY, Zhou ZN, Shi JY, Cui JM, Chen YH. Beta2- but not beta1-adrenoceptor activation modulatesintracellular oxygen availability. J Physiol 2010; 588: 2987-98. (Corresponding Author)
  26. Xiaoping Lin, Zhaoxia Huo, Xingyuan Liu, Yangyang Zhang, Li Li, Hong Zhao, Biao Yan, Ying Liu, Yiqing Yang, Yi-Han Chen. A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect. J Hum Genet 2010. doi:10.1038/jhg.2010.84. (Corresponding Author)
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