Biography

Prof. Paul J. Higgins

Albany Medical College, USA

 

Email: HigginP@mail.amc.edu

 

Qualifications

 

1976  Ph.D., New York University, New York, NY

1973  M.S, Long Island University, Brooklyn, NY

1968  B.S., Iona College, New Rochelle, NY

 

Publications (Selected)

  1. Providence KM, White LA, Tang J, Goncalves J, Staiano-Coico L, Higgins PJ: Epithelial monolayer wounding stimulates binding of USF-1 to an E-box motif in the plasminogen activator inhibitor type 1 gene. J Cell Sci 115:3767-3777, 2002. [PMID:12235287]
  2. Allen RR, Qi L, Higgins PJ: Upstream stimulatory factor regulates E box-dependent PAI-1 transcription in human epidermal keratinocytes. J Cell Physiol 203:156-165, 2005. [PMID:15372465]
  3. Samarakoon R, Higgins CE, Higgins SP, Kutz SM, Higgins, PJ: Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-b1-stimulated smooth muscle cells is pp60c-src/MEK-dependent. J Cell Physiol 204:236-246, 2005. [PMID:1562250]
  4. Kutz SM, Higgins CE, Samarakoon R, Higgins SP, Allen RR, Higgins PJ: TGF-b1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling. Exp Cell Res 312:1093-1105, 2006. [PMID:16457817]
  5. Kortlever RM, Higgins PJ, Bernards R: Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nature Cell Biol 8:877-884, 2006. [PMID:16862142; PMC2954492]
  6. Qi L, Higgins SP, Lu Q, Samarakoon R, Wilkins-Port CE, Ye Q, Higgins CE, Staiano-Coico L, Higgins PJ: SERPINE1 (PAI-1) is a prominent member of the early G0®G1 transition “wound repair” transcriptome in p53 mutant human keratinocytes. J Invest Dermatol 128:749-753, 2008. [PMID:17882266; PMC2654242]
  7. Samarakoon 1-induced plasminogen activatorbR, Higgins SP, Higgins CE, Higgins PJ: TGF- inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling.  J Mol Cell Cardiology 44:527-538, 2008. [PMID:18255094; PMC2394714]
  8. Samarakoon R, Higgins PJ:  Integration of non-SMAD 1-induced plasminogen actiband SMAD signaling in TGF-vator inhibitor type-1 gene expression in VSMC.  Thromb Haemost 100:976-983, 2008. [PMD:19132220; PMC2963177]
  9. Wilkins-Port CE, Ye Q, Mazurkiewicz JE, Higgins PJ:  1+EGF-initiated invasive potential in transformed humanbTGF- keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1.  Cancer Res 69:4081-4091, 2009. [PMID:19383899; PMC2962982]
  10. Freytag J, Wilkins-Port CE, Higgins CE, Carlson JA, Noel A, Foidart J-M, Higgins SP, Samarakoon R, Higgins PJ: PAI-1 regulates the invasive phenotype in human cutaneous squamous cell carcinoma. J Oncol 2009: 1-12, ID963209, 2009. [PMID:20204159; PMC2829771]
  11. Freytag J, Wilkins-Port CE, Higgins CE, Samarakoon R, Higgins PJ: PAI-1 mediates the 1+EGF-induced “scatter” response in transformed human keratinocytes. JbTGF- Invest Dermatol 130:2179-2190, 2010. [PMID:20428185]
  12. Bhatwadekar AD, Guerin EP, Jarajapu YPR, Caballero S, Sheridan C, Kent D, Kennedy L, Lansang MC, Ruscetti FW, Higgins PJ, Bartelmez SH, Grant MB: Transient inhibition of 1 in human diabetic CD34btransforming growth factor-+ cells enhances vascular reparative functions. Diabetes 59:2010-2019, 2010. [PMID:20460428]
  13. Olave NC, Grenett MH, Cadeiras M, Grenett HE, Higgins PJ: Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells.  J Cell Biochem 111: 720-726, 2010. [PMID:20626032]
  14. Samarakoon R, Chitnis SS, Higgins SP, Higgins CE, Krepinsky JC, Higgins PJ: Redox-induced Src kinase and caveolin-1 signaling 1-initiated SMAD2/3 activation and PAI-1 expression.bin TGF-  PLoS ONE 6(7): e22896, 2011. [PMID: 21829547; PMCID: PMC3145778]
  15. Samarakoon R, Overstreet JM, Higgins SP, Higgins PJ: TGF-b1→SMAD/USF2→PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. Cell Tissue Res 347:117-128, 2012.  (Special Issue on “TGF-b in Aging and Disease” (June 4; Epub ahead of print). [PMID:21638209]
  16. Higgins SP, Higgins C.E, Higgins PJ: PAI-1 expression is required for HDACi-induced proliferative arrest in ras-transformed renal epithelial cells. Int J Cell Biol 2011:article no. ID710974, 1-8, 2011.  [PMID: 21912547; PMCID: PMC3168268].
  17. Overstreet J, Higgins PJ: p53/SMAD cooperativity transcriptionally regulates the TGF-1 target gene PAI-1. Nature Cell Biol (submitted).
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