Dr. Zhong-Ping Feng

University of Toronto, Canada

Email: zp.feng@utoronto.ca

Qualifications

2008-Present Associate Professor, University of Toronto, Canada

2003-2008 Assistant Professor, University of Toronto, Canada

1999-2002 Research Scientist, NeuroMed Technologies Inc. Vancouver/Calgary, Canada

Publications (Selected)

1. Guo C., Senzel A., Li, K., Feng Z.-P.* (2010) De novo protein synthesis of syntaxin-1 and dynamin-1 in long-term memory formation requires CREB1 gene transcription in Lymnaea stagnalis. Behav. Genet. Epub ahead of print
2. Pajouhesh H., Feng Z.-P., Zhang L., Ding Y., Zhang L., Pajouhesh H., Belardetti F., Tringham E., Simonson E., Vanderah T.W., Porreca F., Zamponi G.W., Mitscher L.A., Snutch T.P. (2010) Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorganic Med. Chem. Lett. 20(4):1378-83.
3. Feng Z.-P.*, Zhang Z.*, van Kesteren R.E., Straub V., van Nierop P., Jin K., Nejatbakhsh N., Goldberg J.I., Spencer G., Yeoman M., Wildering W., Coorssen J.R., Croll R.P., Buck L., Syed N.I.*, Smit A.B.* (2009) Transcriptome analysis of the central nervous system of the mollusk Lymnaea stagnalis. BMC Genomics. 10(1):451
4. Zamponi GW, Feng Z.-P., Zhang L, Pajouhesh H, Ding Y., Belardetti F., Pajouhesh H., Dolphin D., Mitscher L.A., Snutch T.P. (2009) Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorganic Med. Chem. Lett. 19(22):6467-72.
5. Silverman-Gavrila L.B., Lu T.Z., Prashad, P.C., Nejabakhsh N., Charlton M.P., and Feng Z.-P.* (2009) Neural phosphoproteomics of a chronic hypoxia model - Lymnaea stagnalis. Neurosci. 161(2):632-34
6. Hui K., Kwok T.C.Y., Kosteleski W., Leen J., Roy P.C.*, and Feng Z.-P.* (2009) Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine (DHP) analogous. Euro. J. Pharmacol. 602(2-3):255-61
7. Betourne A., Bertholet A.M., Labroue E, Halley H., Sun H.S., Lorsignol A., Feng Z.-P., French R.J., Penicaud L., Lassalle J.-M., and Frances B. (2009) Involvement of hippocampal CA3 KATp Kir6.2/SUR1 channels in contextual memory. Neuropharmacol. 56, 615-625
8. Sun H.S., French R.J., and Feng Z.-P.* (2009) A simple and reliable technique for identifying both viable and damaged neurons in single brain slices exposed to oxygen and glucose deprivation. Acta Histochem. Feb 7
9. Kwok T.C.Y.#, Hui K.#, Kosteleski W., Ricker N., Selman G., Feng Z.-P.*, and Roy P.C.* (2008) A screen for dihydropyridine (DHP)-resistant worms reveals a mechanism for DHPblockage of mammalian calcium channels. PloS Genetics 4(5):e1000067.
10. Fei G.H., and Feng Z.-P.* (2008) Oxygen supplement rescues chronic hypoxia induced neural suppression. Neurosci. 153(1):318-28.
11. Hui K., and Feng Z.-P.* (2008) Differences in growth cone and somata calcium current properties revealed by NCS-1. Euro J Neurosci. 27(3):631-43
12. Kim I., Mai W., Hui K., Moeckel G., Li C., Liang D., Huang S., Zuo A., Cho S., Li Q., Zhao P., Ma J., Fu Y., Che X., Guo C., Yu X., George A.L. Jr., Coffey R.J., Wu D., Feng Z.-P., and Wu G. (2008) Pkhd1 mediates Pkd2 expression and functions in the same cystogenic pathway. J. Am. Soc. Nephrol. 19(3):455-68
13. Wu J., Sun Z., Sun H.S., Wu J., Weisel R.D., Keating A., Feng Z.-P., and Li R.-K. (2008) Intravenous implantation of bone marrow stem cells decreases neuron damage and improves neural function. Cell Transplant. 16(10):993-1005
14. Fei G., Guo C., Sun S.H., and Feng Z.-P.* (2008) HSP70 reduces chronic hypoxia-induced neural suppression via direct interaction with syntaxin. Adv Exp Med Biol. 605:35-40.
15. Hui K., Fei G., Saab B., Sue J., Roder J., and Feng Z.-P.* (2007) NCS-1 selectively regulates growth cone voltage-dependent Ca2+ channel and is involved in neurite branching in Lymnaea stagnalis neurons. Development. 134:4479-89.
16. Sun H.S., Hui K., Lee D.W.K., and Feng Z.-P.* (2007) Zn sensitivity of high- and low-voltage activated calcium channels. Biophys J. 93(4):1175-83
17. Gardzinski P., Lee D.W.K., Fei G.H., Hui K., Huang G., Sun H.-S., and Feng Z.-P.* (2007) Mechanisms underlying synaptic target cell - induced synaptotagmin clustering during synapse formation between identified Lymnaea neurons. J Physiol. (Lond.) 581:75-90.
18. Fei G., Guo C., Sun S.H., and Feng Z.-P.* (2007) Chronic hypoxia stress induced differential modulation of HSP70 and presynaptic proteins. J Neurochem. 100:50-61.
19. Sun H.S., Feng Z.-P., Barber P.A., Alastair M., and French R.J. (2007) Kir6.2-contraining KATP channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo. Neuroscience 144(4):1509-15. (SHS: Visiting Ph.D. student in my lab)