Dr. Horst Christian Weber
Boston University School of Medicine, USA
Email: christian.weber@bmc.org
Qualifications
2007-present Associate Chief and
Clinical Director, Gastroenterology VA Boston Health Care System, USA
1998-present Staff Physician, VA
Boston Health Care System, USA
1997-present Staff Physician,
Boston Medical Center, USA
Publications (Selected)
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Fathia Gibril, James C.Reynolds, John
L.Doppman, Clara C.Chen, David J.Venzon, Basel Termanini, H.Christian Weber,
Charmaine A.Stewart, and Robert T.Jensen: Somatostatin Receptor Scintigraphy: A
prospective study of its sensitivity compared to other imaging modalities in
detecting primary and metastatic gastrinomas. Ann.Int.Med. 1996; 125 (1): 26-34
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B.Termanini, F.Gibril, C.A.Stewart,
H.C.Weber, R.T.Jensen: A prospective study of the effectiveness of low dose
omeprazole as initial therapy in Zollinger-Ellison syndrome. Alim.Pharm.Ther.
1996; 10: 61-71
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Luis J.Garcia, Tapas K.Pradhan,
H.Christian Weber, Terry W.Moody, Robert T.Jensen: The gastrin-releasing
peptide receptor is differentially coupled to adenylate cyclase and
phospholipase C in different tissues. BBA 1997; 1356: 343-354
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H.C.Weber, D.J.Venzon, R.T.Jensen,
D.C.Metz: Studies on the Interaction Between Zollinger-Ellison Syndrome,
Helicobacter pylori Gastritis and Proton Pump Inhibitor Therapy.
Gastroenterology 1997; 112: 84-91
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C.A.Stewart, B.Termanini, V.Sutliff,
V.Corleto, H.C.Weber, F.Gibril, and R.T.Jensen: Management of Zollinger-Ellison
Syndrome in Pregnancy. Am.J.Obstet.Gynecol.1997; 176 (Number 1, Part 1):
224-233
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S.A.Mantey, H.C.Weber, E.Sainz,
M.Akeson, R.R.Ryan, T.K.Pradhan, E.R.Spindel, J.F.Battey, D.C.Coy, and
R.T.Jensen: Discovery of a high affinity radioligand for the human orphan
receptor, BRS-3, which demonstrates it has a unique pharmacology compared to
other mammalian bombesin receptors. J.Biol.Chem. 1997; 272: 26062-26071
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Debbie J.Marsh, Patricia L.M.Dahia,
Valerie Coulon, Zimu Zheng, Francoise Dorion-Bonnet, Katherine M.Call, Randall
Little, Albert Y.Lin, Rosalind A.Eeles, Alisa M.Goldstein, Shirley V. Hodgson,
Anne-Louise Richardson, Bruce G.Robinson, H.Christian Weber, Michel Longy and
Charis Eng: Allelic imbalance, including deletion of PTEN/MMAC1, at the Cowden
disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and
germline PTEN mutation. Genes, Chromosomes and Cancer 1998; 21: 61-69
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H.C.Weber, L.L.Hampton, R.T.Jensen,
J.F.Battey: Structure and Chromosomal Localization of the Mouse Bombesin
Receptor Subtype 3 Gene. Gene 1998; 211(1): 125-131
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Tapas K.Pradhan, Tatsuro Katsuno, John
E.Taylor, Sun H.Kim, Samuel A.Mantey, Patrick Donohue, H.Christian Weber,
Eduardo Sainz, James F.Battey, David H.Coy, Robert T.Jensen: Identification of
a unique ligand which has high affinity for all four of bombesin receptor
subtypes. Eur.J.Pharmacol. 1998; 343(2-3): 275-287
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R.Ryan, H.C.Weber, W.Hou, E.Sainz,
S.Mantey, J.Battey, D.H.Coy, R.Jensen: Ability of Various Bombesin Receptor
Agonists and Antagonists to Alter Intracellular Signaling of the Human Orphan
Receptor BRS-3. J.Biol.Chem. 1998; 273: 13613-1324
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Lori L.Hampton, Ellen E.Ladenheim,
Mark Akeson, James M.Way, H.Christian Weber, Vincent Sutliff, Robert T.Jensen,
Lara J.Wine, Heinz Arnheiter, and James F.Battey: Loss of Bombesin-Induced
Feeding Suppression in Gastrin-Releasing Peptide Receptor Deficient Mice.
Proc.Natl.Acad.Sci.1998; 95: 3188-3192
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R.Ryan, H.C.Weber, S.Mantey, W.Hou,
M.E.Hilgruber, T.K.Pradhan, D.H.Coy, and R.Jensen:
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Pharmacology and intracellular
signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer
cells. J.Pharm.Exp.Ther. 1998; 287: 366-380
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V.D.Corleto, H.C.Weber, R.T.Jensen,:
Expression of Somatostatin Receptor Subtypes on Guinea Pig Gastric and Colonic
Smooth Muscle Cells. Am. J. Physiol. 1999; 277: G235-G244
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R.Ryan, T.Katsuno, S.Mantey,
T.K.Pradhan, H.C.Weber, D.H.Coy, J.F.Battey, and R.Jensen: Comparative
Pharmacology of the Nonpeptide Neuromedin B Receptor Antagonist PD 168368.
J.Pharm.Exp.Ther. 1999; 290: 1202-1211
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H.C.Weber, R.T.Jensen, and J.F.Battey:
Molecular organization of the mouse gastrin-releasing peptide receptor gene and
its promoter. Gene 2000; 244: 137- 149
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D. Xiao, J. Wang, L.L. Hampton, and
H.C.Weber: The human gastrin-releasing peptide receptor gene structure, its
tissue expression and promoter. Gene 2001; 264(1): 95‑103
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H.C. Weber, J. Walters, J. Leyton, M.
Casibang, S. Purdom, R.T. Jensen, D.H. Coy, C Ellis, G. Clark, and T.W. Moody:
A bombesin receptor subtype‑3 peptide increases nuclear oncogene expression in
a MEK‑1 dependent manner in human lung cancer cells. Eur.J.Pharmacol. 2001;
412: 13‑20
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Harris, P.R., Weber, H.C., Wilcox,
C.M., Jensen, R.T., and Smith, P.D.: Cytokine Profile in Gastric Mucosa in
Helicobacter pylori Infection and Zollinger-Ellison Syndrome. Am J
Gastroenterol 2002; 97: 312-318