Prof. Ben A. Bahr

Biotechnology Research and Training Center

University of North Carolina – Pembroke, USA

William C. Friday Chair and Professor of Molecular Biology and Biochemistry

Email: Bahr@uncp.edu

Qualifications

1989 Ph.D., University of California, USA, Chemistry

1984 B.A., University of California, USA, Molecular Biology and Biochemistry

Publications (selected)

1. Sabatini DM, Barrow RK, Blackshaw S, Burnett PE, Lai MM, Field ME, Bahr BA, Kirsch J, Betz H, and Snyder SH (1999) Interaction of RAFT1 with gephyrin required for rapamycin‑sensitive signaling. Science, 284: 1161‑1164. (PMID: 10325225).
2. Bendiske J, Caba E, Brown QB, and Bahr BA (2002) Intracellular deposition, microtubule destabilization, and transport failure: An “early” pathogenic cascade leading to synaptic decline. J Neuropathol Exp Neurol, 61: 640-650.  (PMID: 12125743).
3. Bendiske J and Bahr BA (2003) Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis – an approach for slowing Alzheimer disease? J Neuropathol Exp Neurol, 62: 451-463. (PMID: 12769185).
4. Caba E and Bahr BA (2004) Biphasic activation of NF-kB in the excitotoxic hippocampus. Acta Neuropathologica, 108: 173-182. (PMID: 15138780).
5. Karanian DA, Brown QB, Makriyannis A, and Bahr BA (2005) Blocking cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity in hippocampus. Eur J Pharmacol, 508: 47-56.  (PMID: 15680253).
6. Karanian DA, Brown QB, Makriyannis A, Kosten TA, and Bahr BA (2005) Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. J Neuroscience, 25: 7813-7820. (PMID: 16120783).
7. Karanian DA, Baude A, Brown QB, Parsons C, and Bahr BA (2006) 3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism. Hippocampus, 16: 834-42. (PMID: 16897723).
8. Butler D, Bendiske J, Michaelis ML, Karanian DA, and Bahr BA (2007) Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers. Eur J Pharmacol, 562: 20-27. (PMID: 17336290).
9. Chicoine LM and Bahr BA (2007) Excitotoxic protection by polyanionic polysaccharide: Evidence of a cell survival pathway involving AMPA receptor-MAPK interactions. J Neuroscience Res, 85: 294-302. (PMID: 17131415).
10. Kosten TA, Karanian DA, Yeh J, Haile CN, Kim JJ, Kehoe P, and Bahr BA (2007) Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience. Neurobiol Learning Memory 88:167-176. (PMID:  17543553).
11. Karanian DA, Karim SL, Wood JT, Williams JS, Lin S, Makriyannis A, and Bahr BA (2007) Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage. J Pharmacol Exp Ther, 322: 1059-1066. (PMID: 17545313).
12. Ryzhikov S and Bahr BA (2008) Gephyrin alterations due to protein accumulation stress are reduced by the lysosomal modulator Z-Phe-Ala-diazomethylketone. J Mol Neuroscience, 34: 131-139.  (PMID: 18204977).
13. Pin SS and Bahr BA (2008) Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists. Eur J Pharmacol, 587: 8-15. (PMID: 18420188).
14. Naidoo V, Nikas SP, Karanian DA, Hwang J, Zhao J, Wood JT, Alapafuja SO, Vadivel SK, Butler D, Makriyannis A, and Bahr BA (2011) A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity. J Mol Neuroscience, 43: 493-502. (PMID: 21069475).
15. Wisniewski ML, Hwang J, and Bahr BA (2011) Submicromolar Aβ42 reduces hippocampal glutamate receptors and presynaptic markers in an aggregation-dependent manner. Biochim Biophys Acta, 1812: 1664-74. (PMID: 21978994).
16. Butler D, Hwang J, Estick C, Nishiyama A, Kumar SS, Baveghems C, Young-Oxendine HB, Wisniewski ML, Charalambides A, and Bahr BA (2011) Protective effects of positive lysosomal modulation in Alzheimer’s disease transgenic mouse models. PLoS One, 6: e20501 (pp: 1-16).  (PMID: 21695208).
17. Naidoo V, Karanian DA, Vadivel SK, Locklear JR, Wood JT, Nasr M, Quizon PM, Graves EE, Shukla V, Makriyannis A, and Bahr BA (2012) Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase – dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics, 9: 801-13. (PMID: 22270809).
18. Viswanathan K, Hoover DJ, Hwang J, Wisniewski ML, Ikonne US, Bahr BA, and Wright DL (2012) Nonpeptidic lysosomal modulators derived from Z-Phe-Ala-diazomethylketone for treating protein accumulation diseases. ACS Med Chem Lett, 3: 920-924. (PMID: 24900408).
19. Melo CV, Okumoto S, Gomes JR, Baptista MS, Bahr BA, Frommer WB & Duarte CB (2013) Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons. Neuroscience, 237: 66-86. (PMID: 23384605).
20. Filipovic R, Kumar SS, Bahr BA & Loturco J (2014) Slice cultures for studying migration of neuronal progenitor cells derived from human embryonic stem cells. Curr Protoc Stem Cell Biol, 29: 1H.7.1-14. (PMID: 24838914).
21. Bahr BA (2014) A single pathway targets several health challenges of the elderly. Rejuvenation Res, 17: 382-384. (PMID: 24953230).

Profile Details

http://www.uncp.edu/academics/research/biotech-center/research