Prof. Patricia A. Kruk

University of South Florida, USA

Email: pkruk@health.usf.edu

Qualifications

1992 Ph.D., Medical Sciences, University of British Columbia, Canada

1983 M.Sc., Zoology, University of Alberta, Edmonton, Canada

1980 B.Sc., Honor’s in Biological Sciences, Concordia University, Canada

Publications(Selected)

1. Alfonso-De Matte M.A., P.A. Kruk*. Phosphotidylinositol-triphosphate kinase- and c-jun N-terminal kinase-dependent induction of telomerase by calcium requires pyk2. Cancer Research 64:23-26, 2004
2. Yang H., C.C. Ou, R.I. Feldman, S.V. Nicosia, P.A. Kruk, J.Q. Cheng. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer Res. 64:463-467, 2004
3. Johnson N.C., H.C. Dan, J.Q. Cheng, P.A. Kruk*. Loss of XIAP in BRCA1 185delAG human ovarian surface epithelial cells results in aberrant active caspase 3 ubiquitination. Exp. Cell Res. 298:9-16, 2004
4. Shoup B.L., N.E. Lowell, P.A. Kruk*. Inhibition of telomerase improves chemosensitivity in cisplatin resistant ovarian cancer cells. Cancer Therapy 2: 501-510, 2004
5. Tebes S, Kruk PA*. The Genesis of RNA Interference, Its Potential Clinical Applications, and Implications in Gynecologic Cancer. Gynecol. Oncol. 99:736-741, 2005
6. Bermudez Y, Erasso D, Johnson NC, Alfonso MY, Lowell NE, Kruk PA*. Telomerase Confers Resistance to Caspase-Mediated Apoptosis. Clin. Intervent. Aging. 1:155-167, 2006
7. Yang H., He L., Kruk P., Nicosia S.V., Cheng J.Q. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. Intl. J. Cancer. 119:2304-2312, 2006
8. Bermudez Y, Ahmadi S, Lowell NE, Kruk PA*. Vitamin E suppresses telomerase activity in ovarian cancer cells. Cancer Detect. Prevent. 31:119-128, 2007
9. Bermudez Y, Yang H, Saunders BO, Cheng JQ, Nicosia SV, Kruk PA*. VEGF- and LPA-induced telomerase activity in human ovarian cancer cells is Sp1-dependent. Gynecol. Oncol. 106:526-537, 2007
10. Yang H, Kong W, He L, Zhao J-J, O’Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ. MicroRNA expression profiling in human ovarian cancer: miRNA-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 68:424-433, 2008
11. Bermudez Y, Yang H, Cheng JQ, Kruk PA*. Pyk2/ERK1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor. Growth Factors 26:1-11, 2008
12. O’Donnell JD, Johnson NC, Turbeville TD, Alfonso MY, Kruk PA*. BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cancer cells. In Vitro Cell Dev. Biol. 44:357-67, 2008
13. Anderson NC, Bermudez Y, Badgwell D, Chen R, Nicosia SV, Bast RC, Kruk PA*. Urinary levels of Bcl-2 are elevated in ovarian cancer patients. GynecolOncol 11:60-7, 2009
14. Zhang Y, Zhang M, Dong H, Yong S, Li X, Olashaw N, Kruk PA, Cheng JQ, Bai W, Chen J, Nicosia SV, Zhang X. Deacetylation of cortactin by Sirt1 promotes cell migration. Oncogene 28:445-69, 2009
15. Walker RF, Pakula LC, Sutcliffe MJ, Kruk PA, Graakjaer J, Shay JW. A case study of disorganized development and its possible relevance to genetic determinants of aging. Mech. Ageing Develop. 130:350-356, 2009
16. Guo J, Shu S-K, He L, Lee Y-C, Kruk PA, Grenman S, Nicosia SV, Coppola D, Cheng JQ. Deregulation of the IKBK oncogene is associated with tumor progression, poor prognosis and cisplatin resistance in ovarian cancer. Amer. J. Pathol. 175:324-33, 2009
17. Drenberg C, Livingston S, Chen R, Kruk PA, Nicosia SV. Expression of Semaphorin 3F and its receptors in epithelial ovarian cancer, fallopian tubes, and secondary Mullerian tissues. Obstet. Gynecol. Intl. doi:10.1155/2009/730739, 2009
18. Anderson NS, Turner L, Livingston S, Chen R, Nicosia SV, Kruk  PA*. Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation. J. Ovarian Research. 2:16 (1-11), 2009
19. O’Donnell JD, Linger RJ, Kruk PA*. BRCA1 del185AG mutant protein, BRAt, up-regulates maspin expression in ovarian epithelial cells. Gynecol. Oncol. 116:262-268, 2010
20. Drenberg CD, Saunders BO, Wilbanks GD, Chen R, Nicosia RF, Kruk PA, Nicosia SV. Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer. Gynecol. Oncol. GynecolOncol. 117:117-24, 2010