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Dr. Paul E. Sijens

University Medical Center Groningen, Netherlands

Email: p.e.sijens@umcg.nl


1988 Ph.D., Rijksuniversiteit Utrecht

Publications (selected)

  1. Baron P, Dorrius MD, Kappert P, Oudkerk M, Sijens PE. Diffusion-weighted imaging of normal fibroglandular breast tissue: influence of microperfusion and fat suppression technique on the apparent diffusion coefficient. NMR Biomed in press 4. 329
  2. Sijens PE, Dorrius MD, Kappert P, Baron P, Pijnappel RM, Oudkerk M. Quantitative multivoxel proton CSI of the breast. Magn Reson imaging in press 1. 871
  3. Sijens PE, Dorrius MD. Spectroscopic imaging in breast cancer. Imaging Decis MRI in Press
  4. Sijens PE. Letter to the Editor re: Andrés Server, et al., “Proton magnetic resonance spectroscopy in the distinction of high-grade cerebral gliomas from single metastatic brain tumors”. Acta Radiol in Press 1. 091
  5. Sijens PE, Edens MA, Bakker SHL, Stolk RP. MRI determined fat content of human liver, pancreas and kidney. Word J Gastroentrol in press 2. 081
  6. Viddeleer AR, Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M. MR intensity measurements of non-denervated muscle in patients following severe forearm trauma. NMR Biomed in press 4.329
  7. Verbruggen KT, Meiners LC, Sijens PE, Lunsing RJ, van Spronsen FJ, Brouwer OF. Magnetic resonance imaging and proton magnetic resonance spectroscopy in the diagnostic evaluation of developmental delay. Eur J Pediatr Neurol 2009;13:181-190 1. 421
  8. Dikkers R, Greuter MJW, Kristanto W, van Ooijen PMA, Sijens PE, Willems TP, Oudkerk M. The assessment of image quality of 64-row dual source versus single source CT coronary angiography on heart rate: a phantom study. Eur J Radiol 2009;70:61-68 2. 339
  9. Olthof AW, Sijens PE, Kreeftenberg HG, Kappert P, van der Jagt EJ, Oudkerk M. Non-invasive liver iron concentration measurement by MRI: comparison of two validated protocols. Eur J Radiol 2009;71:116-21 2. 339
  10. Viddeleer AR, Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M. Long term reproducibility of phantom image intensities in nonouniformity corrected STIR-MRI examinations of skeletal muscle. Magn Reson Mater Phy 2009;22:201-209 1. 844
  11. Edens MA, van Ooijen PMA, Post WJ, Haagmans MJF, Kristanto W, Sijens PE, van der Jagt EJ, Stolk RP. Ultrasonography to quantify hepatic fat content: validation by 1H Magnetic Resonance Spectroscopy. Obesity 2009;17:2239-2244 2. 762
  12. Sijens PE, Westerlaan HE, de Groot JC, Boon M, Potze JH, van Spronsen FJ, Lunsing RJ, Oudkerk M. MR spectroscopy of diffusion tensor imaging of the brain in Sjögren-Larsson syndrome. Mol Genet Metab 2009;98:167-171 2. 629
  13. Sijens PE. Parametric exploration of the liver by magnetic resonance methods. Eur Radiol 2009;19:2594-2607 3. 651
  14. Sijens PE, Lubbers DD. Comparison of two fast MRI methods for perfusion imaging of the heart. Imaging Decis MRI 2009;13:43-48
  15. Verbruggen KT, Maurits NM, van Spronsen FJ, Brouwer OF, Sijens PE. Quantitative multivoxel proton spectroscopy of the brain in developmental delay. J Magn Reson Imaging 2009;30:716-721 2. 658
  16. Sijens PE, Oudkerk M, Letter to the Editor re: Richard J. Maddock et al. “Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance study at 1.5 tesla” [Psychiatry Research Neuroimaging 2006; 148:47-54]. Psych Res Neuroim 2008;162:173-174 2. 666
  17. Irwan R, Edens MA, Sijens PE. Assessment of the variations in fat content in normal liver using a fast quantification: MR imaging method in comparison with results obtained by spectroscopic imaging. Eur Radiol 2008;18:806-813 3. 651
  18. Sijens PE, Mostert JP, Irwan R, Potze JH, Oudkerk M, De Keyser, J. The impact of fluoxetine on the human brain in multiple sclerosis as quantified by 1H MR Spectroscopy and diffusion tensor imaging: preliminary findings. Psych Res Neuroim 2008;174:274-282 2. 666
  19. Sijens PE, Smit GPA, Rödiger LA, van Spronsen FJ, Oudkerk M, Rodenburg RJ, Lunsing RJ. MR Spectroscopy of the brain in Leigh syndrome. Brain Dev 2008;30:579-83 1. 414
  20. Borra R, Lautamäki R, Parkkola R, Komu M, Sijens PE, Hälsten K, Bergman J, Iozzo P, Nuutila P. Inverse association between liver fat content and hepatic glucose uptake in patients with type 2 diabetes. Metab Clin Exper 2008;57:1445-1451 2. 920
  21. Sijens PE, Rödiger LA, Meiners LC, Lunsing RJ. 1H magnetic resonance spectroscopy in monocarboxylate transporter 8 gene deficiency. J Clin Endocrin Metab 2008;93:1854-9 6. 32
  22. Sijens PE, Alkefaji H, Lunsing RJ, van Spronsen FJ, Meiners LC, Oudkerk M, Verkade HJ. Quantitative multivoxel MR spectroscopy of the brain in children with acute liver failure. Eur Radiol 2008;18:2601-2609 3. 651
  23. Irwan R, de Vries HBK, Sijens PE. The impact of scan length on the exposure levels in 16-row MSCT and 64-row MSCT: a phantom study. Acad Radiol 2008;15: 1142-7 2. 021
  24. Olthof AW, Sijens PE, Kreeftenberg HG, Kappert P, Irwan R, van der Jagt EJ, Oudkerk M. The impact of hematologic disease and inflammation on the relationship between liver iron concentration as determined by magnetic resonance imaging and serum ferritin concentration. Magn Reson Imaging 2007;25:228-231 1. 871
  25. Irwan R, Lubbers DD, van der Vleuten PA, Kappert P, Gotte MJ, Sijens PE. Parallel imaging for first-pass myocardial perfusion. Magn Reson Imaging 2007;5:678-683 1. 871
  26. Sijens PE, Fock JM, Meiners LC, Potze JH, Irwan R, Oudkerk M. MR spectroscopy and diffusion tensor imaging of the brain in congenital muscular dystrophy with merosin deficiency: metabolite level decreases, fractional anisotropy decreases, and apparent diffusion coefficient increases in the white matter. Brain Dev 2007;19:317-321 1. 401
  27. Verbruggen KT, Knijff WA, Lunsing RJ, Hordijk R, Sijens PE, Verhoeven NM, Salomons GS, Goorhuis-Brouwer SM, van Spronsen FJ. GAMT deficiency causing global developmental delay: differences between formal testing and clinical observation. Eur J Pediatr 2007;166:921-925 1. 416
  28. Verbruggen KT, Sijens PE, Schulze A, Lunsing RJ, Jacobs C, Salomons GS, van Spronsen FJ. Successfull treatment of a guanidinoacetate methyltransferase deficient patient: findings with relevance to treatment strategy and pathofysiology. Mol Genet Metab 2007;91:294-296 2. 629
  29. van Oostrum JCH, Sijens PE, Roos RAC, Leenders KL. 1H magnetic resonance spectroscopy in preclinical Huntington disease. Brain Res 2007;1168;67-71 2. 494
  30. Sijens PE, Heesters MAAM, Enting RH, Potze JH, Irwan R, Meiners LC, Oudkerk M. Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in astrocytoma under temozolomide chemotherapy Cancer Invest 2007;25:706-710 1. 976