Prof. Noah Isakov
The Joseph H. Krupp Chair in Cancer Immunobiology
The Shraga Segal Department of Microbiology, Immunology and Genetics
Ben Gurion University of the Negev, USA
Professor
Email: noah@bgu.ac.il
Qualifications
1981 Ph.D., The Weizmann Institute of Science
1976 M.Sc., The Weizmann Institute of Science
1974 B.Sc., Ben Gurion University of the Negev
Publications (Selected)
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Gelkop, S.,
Babichev, Y. and Isakov, N. 2001. T cell activation induces direct binding of
the Crk adapter protein to the regulatory subunit of phosphatidylinositol
3-kinase (p85) via a complex mechanism involving the Cbl protein. J. Biol. Chem. 276: 36174-36182.
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Isakov N. and Altman, A. 2002. Protein
kinase C-qin T
cell activation. Ann. Rev. Immunol. 20: 761-794.
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Ohana-Malka, O., Benharroch, D., Isakov,
N., Prinsloo, I., Shubinsky, G., Sacks, M. and Gopas, J. 2003. Selectins and
anti-CD15 (Lewis X/A) antibodies transmit activation signals in Hodgkin’s
lymphoma derived cell lines. Exp. Hem. 31: 1057-1065.
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Babichev, Y., Tamir, A., Park, M., Muallem,
S. and Isakov, N. 2005. Cloning, expression and functional characterization of
the putative regeneration and tolerance factor (RTF/TJ6) as a functional
vacuolar ATPase proton pump regulatory subunit with a conserved sequence of
immunoreceptor tyrosine-based activation motif. Int. Immunol. 17: 1303-1313.
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Gelkop, S. Gish, J., Babichev, Y., Pawson,
T. and Isakov, N. 2005. T cell activation-induced CrkII binding to the ZAP-70
protein tyrosine kinase is mediated by Lck-dependent phosphorylation of ZAP-70
tyrosine 315. J. Immunol. 175: 8123-8132.
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Isakov, N. 2008. A
new twist to adaptor proteins contributes to lymphocyte cell signaling
regulation.Trends Immunol. 29: 388-396.
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Glanz, A., Albrecht, J.-C., Heinemann, S.,
Fleckenstein, B., Isakov, N. and Biesinger, B. 2008. NF-kB activation by the viral
oncoprotein StpC enhances IFNgproduction in T cells. Immunol. Cell Biol. 86: 622–630.
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Cohen,
S., Braiman, A., Shubinsky, G., Ohayon, A., Altman, A. and Isakov, N. 2009. PKCqis
required for hemostasis and positive regulation of thrombin-induced platelet
aggregation anda-granule
secretion.Biochem. Biophys. Res Commun. 385: 22-27.
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Ohayon,
A., Babichev, Y., Pasvolsky, R., Dong, G., Sztarkier, I., Benharroch, D.,
Altman, A. and Isakov, N. 2010. Hodgkin’s lymphoma cells exhibit high
expression levels of the PICOT protein. J.
Immunotoxicol. 7: 8-14.
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Ohayon, A., Babichev, Y., Galperin, M.,
Altman, A. and Isakov, N. 2010.Widespread Expression of PICOT in Mouse and
Human Tissues with Predominant Localization to Epithelium. 2010. J. Histochem. Cytochem. 58: 799-806.
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Ohayon,
A., Golenser, J., Sinay, R., Tamir, A., Altman, A., Pollack, Y. and Isakov, N.
2010. PKCθ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced
cerebral malaria. Infect. Immunity 78: 4195-4205.
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Kong, K-F., Yokosuka, T., Canonigo-Balancio, A. J., Isakov, N.,
Saito, T. and Altman, A. 2011. A novel motif in the V3
domain of protein kinase C-θ (PKCθ) determines its immunological synapse
localization and functions in T cells via association with CD28. Nat. Immunol.12:1105-1112. doi: 10.1038/ni. 2120.
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Cohen, S., Braiman, A.,
Shubinsky, G. and Isakov, N. 2011. Protein kinase C-theta in
platelet activation. FEBS Lett.585:3208-3215. doi:10.1016/j.febslet.2011.09.014.
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Gelkop, S., Weisman, B., Pulak, R. N., Zharhary, D. and Isakov, N. 2012. Development of
unique antibodies directed again steach of the six different phosphotyrosine
residues within the T cell receptor
CD3zchain. J. Immunol. Methods. 375: 129-37. doi:10.1016/j.jim.2011.10.001.
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Isakov, N. and Altman, A. 2012. PKC-theta-mediated
signal delivery from the TCR/CD28 surface receptors.Front. Immunol. 3 :273. doi:10.3389/fimmu.2012.00273.
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Isakov, N. and Altman, A. 2013. Regulation of immune system cell functions by protein kinase C. Front. Immunol. 4:384. doi: 10.3389/fimmu.2013.00384.
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Nath, R.P., Dong, G., Braiman, A. and Isakov, N.
2014. Immunophilins Control T Lymphocyte
Adhesion and Migration by Regulating CrkII Binding to C3G. J. Immunol. 193: 3966-3977. DOI: 10.4049/jimmunol.1303485.
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Zurgil, U.,
Ben-Ari, A., Atias, K., Isakov, N., Apte, R. and Livneh, E. 2014. PKCη promotes
senescence induced by oxidative stress and chemotherapy. Cell Death & Disease 5, e1531. DOI:
10.1038/cddis.2014.481.
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Nath, P. R. and Isakov, N. 2014. PKC-theta-regulated
signaling in health and disease. Biochem. Soc. Trans. 42:1484-1489. DOI:10.1042/BST20140180.
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Nath, P. R. and Isakov, N. 2015. Insights into Peptidyl Prolylcis-transIsomerase Structure and Function in
Immunocytes. Immunol. Letters 163: 120-131.
Last Updated: July, 2015