Biography

Prof. Noah Isakov

The Joseph H. Krupp Chair in Cancer Immunobiology

The Shraga Segal Department of Microbiology, Immunology and Genetics

Ben Gurion University of the Negev, USA

Professor


Email: noah@bgu.ac.il


Qualifications

1981 Ph.D., The Weizmann Institute of Science
1976 M.Sc., The Weizmann Institute of Science

1974 B.Sc., Ben Gurion University of the Negev


Publications (Selected)

  1. Gelkop, S., Babichev, Y. and Isakov, N. 2001. T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein. J. Biol. Chem. 276: 36174-36182.
  2. Isakov N. and Altman, A. 2002. Protein kinase C-qin T cell activation. Ann. Rev. Immunol. 20: 761-794.
  3. Ohana-Malka, O., Benharroch, D., Isakov, N., Prinsloo, I., Shubinsky, G., Sacks, M. and Gopas, J. 2003. Selectins and anti-CD15 (Lewis X/A) antibodies transmit activation signals in Hodgkin’s lymphoma derived cell lines. Exp. Hem. 31: 1057-1065.
  4. Babichev, Y., Tamir, A., Park, M., Muallem, S. and Isakov, N. 2005. Cloning, expression and functional characterization of the putative regeneration and tolerance factor (RTF/TJ6) as a functional vacuolar ATPase proton pump regulatory subunit with a conserved sequence of immunoreceptor tyrosine-based activation motif. Int. Immunol. 17: 1303-1313.
  5. Gelkop, S. Gish, J., Babichev, Y., Pawson, T. and Isakov, N. 2005. T cell activation-induced CrkII binding to the ZAP-70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of ZAP-70 tyrosine 315. J. Immunol. 175: 8123-8132.
  6. Isakov, N. 2008. A new twist to adaptor proteins contributes to lymphocyte cell signaling regulation.Trends Immunol. 29: 388-396.
  7. Glanz, A., Albrecht, J.-C., Heinemann, S., Fleckenstein, B., Isakov, N. and Biesinger, B. 2008. NF-kB activation by the viral oncoprotein StpC enhances IFNgproduction in T cells. Immunol. Cell Biol. 86: 622–630.
  8. Cohen, S., Braiman, A., Shubinsky, G., Ohayon, A., Altman, A. and Isakov, N. 2009. PKCqis required for hemostasis and positive regulation of thrombin-induced platelet aggregation anda-granule secretion.Biochem. Biophys. Res Commun. 385: 22-27.
  9. Ohayon, A., Babichev, Y., Pasvolsky, R., Dong, G., Sztarkier, I., Benharroch, D., Altman, A. and Isakov, N. 2010. Hodgkin’s lymphoma cells exhibit high expression levels of the PICOT protein. J. Immunotoxicol. 7: 8-14.
  10. Ohayon, A., Babichev, Y., Galperin, M., Altman, A. and Isakov, N. 2010.Widespread Expression of PICOT in Mouse and Human Tissues with Predominant Localization to Epithelium. 2010. J. Histochem. Cytochem. 58: 799-806.
  11. Ohayon, A., Golenser, J., Sinay, R., Tamir, A., Altman, A., Pollack, Y. and Isakov, N. 2010. PKCθ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria. Infect. Immunity 78: 4195-4205.
  12. Kong, K-F., Yokosuka, T., Canonigo-Balancio, A. J., Isakov, N., Saito, T. and Altman, A. 2011. A novel motif in the V3 domain of protein kinase C-θ (PKCθ) determines its immunological synapse localization and functions in T cells via association with CD28. Nat. Immunol.12:1105-1112. doi: 10.1038/ni. 2120.
  13. Cohen, S., Braiman, A., Shubinsky, G. and Isakov, N. 2011. Protein kinase C-theta in platelet activation. FEBS Lett.585:3208-3215. doi:10.1016/j.febslet.2011.09.014.
  14. Gelkop, S., Weisman, B., Pulak, R. N., Zharhary, D. and Isakov, N. 2012. Development of unique antibodies directed again steach of the six different phosphotyrosine residues within the T cell receptor CD3zchain. J. Immunol. Methods. 375: 129-37. doi:10.1016/j.jim.2011.10.001.
  15. Isakov, N. and Altman, A. 2012. PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors.Front. Immunol. 3 :273. doi:10.3389/fimmu.2012.00273.
  16. Isakov, N. and Altman, A. 2013. Regulation of immune system cell functions by protein kinase C. Front. Immunol. 4:384. doi: 10.3389/fimmu.2013.00384.
  17. Nath, R.P., Dong, G., Braiman, A. and Isakov, N. 2014. Immunophilins Control T Lymphocyte Adhesion and Migration by Regulating CrkII Binding to C3G. J. Immunol. 193: 3966-3977. DOI: 10.4049/jimmunol.1303485.
  18. Zurgil, U., Ben-Ari, A., Atias, K., Isakov, N., Apte, R. and Livneh, E. 2014. PKCη promotes senescence induced by oxidative stress and chemotherapy. Cell Death & Disease 5, e1531. DOI: 10.1038/cddis.2014.481.
  19. Nath, P. R. and Isakov, N. 2014. PKC-theta-regulated signaling in health and disease. Biochem. Soc. Trans. 42:1484-1489. DOI:10.1042/BST20140180.
  20. Nath, P. R. and Isakov, N. 2015. Insights into Peptidyl Prolylcis-transIsomerase Structure and Function in Immunocytes. Immunol. Letters 163: 120-131.


Last Updated: July, 2015

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