Dr. Abdul Ali Peer Zada

Pathology and Clinical Laboratory, King Fahad Medical City (KFMC), Saudi Arabia

Email: azada@kfmc.med.sa

Qualifications

2004 Ph.D., Human Biology, Ludwig Maximillian's University (LMU) Munich, Germany

Publications (Selected)

1. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood. 2010 Mar 4;115(9):1768-78. doi: 10.1182/blood-2009-08-240101. Epub 2009 Dec 22. PMID: 20029046; PMCID: PMC2832809
2. Doering M, Ba LA, Lilienthal N, Nicco C, Scherer C, Abbas M, Zada AA, Coriat R, Burkholz T, Wessjohann L, Diederich M, Batteux F, Herling M, Jacob C. Synthesis and selective anticancer activity of organochalcogen based redox catalysts. J Med Chem. 2010 Oct 14;53(19):6954-63. doi: 10.1021/jm100576z. PMID: 20836556
3. Geletu M, Balkhi MY, Peer Zada AA, Christopeit M, Pulikkan JA, Trivedi AK, Tenen DG, Behre G. Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9. Blood. 2007 Nov 1;110(9):3301-9. doi: 10.1182/blood-2007-01-071035. Epub 2007 Aug 1. PMID: 17671234
4. Hoemme C, Peerzada A, Behre G, Wang Y, McClelland M, Nieselt K, Zschunke M, Disselhoff C, Agrawal S, Isken F, Tidow N, Berdel WE, Serve H, Müller-Tidow C. Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip. Blood. 2008 Mar 1;111(5):2887-95. doi: 10.1182/blood-2007-03-079921. Epub 2007 Nov 16. PMID: 18024792; PMCID: PMC2254548
5. Alfares A, Alfadhel M, Wani T, Alsahli S, Alluhaydan I, Al Mutairi F, Alothaim A, Albalwi M, Al Subaie L, Alturki S, Al-Twaijri W, Alrifai M, Al-Rumayya A, Alameer S, Faqeeh E, Alasmari A, Alsamman A, Tashkandia S, Alghamdi A, Alhashem A, Tabarki B, AlShahwan S, Hundallah K, Wali S, Al-Hebbi H, Babiker A, Mohamed S, Eyaid W, Zada AAP. A multicenter clinical exome study in unselected cohorts from a consanguineous population of Saudi Arabia demonstrated a high diagnostic yield. Mol Genet Metab. 2017 Jun;121(2):91-95. doi: 10.1016/j.ymgme.2017.04.002. Epub 2017 Apr 7. PMID: 28454995
6. Fedorchenko O, Stiefelhagen M, Peer-Zada AA, Barthel R, Mayer P, Eckei L, Breuer A, Crispatzu G, Rosen N, Landwehr T, Lilienthal N, Möllmann M, Montesinos-Rongen M, Heukamp L, Dürig J, Hallek M, Fingerle-Rowson G, Herling M. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood. 2013 May 16;121(20):4126-36. doi: 10.1182/blood-2012-11-466250. Epub 2013 Apr 1. PMID: 23547049
7. Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu M, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G. Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML. Leukemia. 2010 May;24(5):914-23. doi: 10.1038/leu.2010.37. Epub 2010 Apr 8. PMID: 20376080; PMCID: PMC2923485
8. Rangatia J, Vangala RK, Singh SM, Peer Zada AA, Elsässer A, Kohlmann A, Haferlach T, Tenen DG, Hiddemann W, Behre G. Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction. Oncogene. 2003 Jul 24;22(30):4760-4. doi: 10.1038/sj.onc.1206664. PMID: 12879022
9. Zada AA, Singh SM, Reddy VA, Elsässer A, Meisel A, Haferlach T, Tenen DG, Hiddemann W, Behre G. Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation. Oncogene. 2003 Apr 17;22(15):2296-308. doi: 10.1038/sj.onc.1206393. PMID: 12700665.
10. Trivedi AK, Bararia D, Christopeit M, Peerzada AA, Singh SM, Kieser A, Hiddemann W, Behre HM, Behre G. Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination. Oncogene. 2007 Mar 15;26(12):1789-801. doi: 10.1038/sj.onc.1209964. Epub 2006 Sep 18. PMID: 16983342
11. Bararia D, Trivedi AK, Zada AA, Greif PA, Mulaw MA, Christopeit M, Hiddemann W, Bohlander SK, Behre G. Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. Leukemia. 2008 Apr;22(4):800-7. doi: 10.1038/sj.leu.2405101. Epub 2008 Jan 31. PMID: 18239623
12. Salem N, Kamal I, Al-Maghrabi J, Abuzenadah A, Peer-Zada AA, Qari Y, Al-Ahwal M, Al-Qahtani M, Buhmeida A. High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma. Future Oncol. 2016 Feb;12(3):323-31. doi: 10.2217/fon.15.325. Epub 2016 Jan 19. PMID: 26814712
13. Zada AA, Pulikkan JA, Bararia D, Geletu M, Trivedi AK, Balkhi MY, Hiddemann WD, Tenen DG, Behre HM, Behre G. Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. Leukemia. 2006 Dec;20(12):2137-46. doi: 10.1038/sj.leu.2404438. Epub 2006 Nov 2. PMID: 17082780
14. Alhebbi H, Peer-Zada AA, Al-Hussaini AA, Algubaisi S, Albassami A, AlMasri N, Alrusayni Y, Alruzug IM, Alharby E, Samman MA, Ayoub SZ, Maddirevula S, Peake RWA, Alkuraya FS, Wali S, Almontashiri NAM. New paradigms of USP53 disease: normal GGT cholestasis, BRIC, cholangiopathy, and responsiveness to rifampicin. J Hum Genet. 2021 Feb;66(2):151-159. doi: 10.1038/s10038-020-0811-1. Epub 2020 Aug 6. PMID: 32759993
15. Zada AA, Geletu MH, Pulikkan JA, Müller-Tidow C, Reddy VA, Christopeit M, Hiddemann WD, Behre HM, Tenen DG, Behre G. Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63. Proteomics. 2006 Nov;6(21):5705-19. doi: 10. Behre G, Reddy VA, Tenen DG, Hiddemann W, Zada AA, Singh SM. Proteomic analysis of transcription factor interactions in myeloid stem cell development and leukaemia. Expert Opin Ther Targets. 2002 Aug;6(4):491-5. doi: 10.1517/14728222.6.4.491. PMID: 12223063.1002/pmic.200600307. PMID: 17001604
16. Lilienthal N, Prinz C, Peer-Zada AA, Doering M, Ba LA, Hallek M, Jacob C, Herling M. Targeting the disturbed redox equilibrium in chronic lymphocytic leukemia by novel reactive oxygen species-catalytic 'sensor/effector' compounds. Leuk Lymphoma. 2011 Jul;52(7):1407-11. doi: 10.3109/10428194.2011.568077. Epub 2011 Mar 29. PMID: 21476834
17. Faqeih EA, Bastaki L, Rosti RO, Spencer EG, Zada AP, Saleh MA, Um K, Gleeson JG. Novel STAMBP mutation and additional findings in an Arabic family. Am J Med Genet A. 2015 Apr;167A(4):805-9. doi: 10.1002/ajmg.a.36782. Epub 2015 Feb 18. PMID: 25692795
18. Bahamat AA, Assidi M, Lary SA, Almughamsi MM, Peer Zada AA, Chaudhary A, Abuzenadah A, Abu-Elmagd M, Al-Qahtani M. Use of Array Comparative Genomic Hybridization for the Diagnosis of DiGeorge Syndrome in Saudi Arabian Population. Cytogenet Genome Res. 2018;154(1):20-29. doi: 10.1159/000487094. Epub 2018 Feb 17. PMID: 29455205

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