Dr. Wenhao Zhang

Harvard Medical School, USA

Email: Wenhao.Zhang@childrens.harvard.edu

Qualifications

2012-2017 Ph.D., Tsinghua University, China

2008-2012 B.S., Sichuan University, China

Publications (Selected)

1. C. Chu*, W. Zhang*, Y. Kang, C. Si, W. Ji, Y. Niu, Y. Zhang. “Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta”, Developmental Cell, 2021. https://doi.org/10.1016/j.devcel.2021.09.012
2. Z. Xie*, W. Zhang*, Y. Zhang. “Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation”. Cell Reports, 2021. https://doi.org/10.1016/j.celrep.2022.110407
3. W. Zhang*, Z. Chen*, Q. Yin, D. Zhang, C. Racowsky, Y. Zhang. “Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula”. Genes & development, 2019. http://www.genesdev.org/cgi/doi/10.1101/gad.323105.118
4. B. Zhang*, X. Wu*, W. Zhang*, W. Shen, Q. Sun, K. Liu, Y. Zhang, Q. Wang, Y. Li, A. Meng, W. Xie. “Widespread enhancer dememorization and promoter priming during paternal-to-zygotic transition. Molecular Cell, 2018. https://doi.org/10.1016/j.molcel.2018.10.017
5. W. Zhang*, W. Xia*, Q. Wang, A. Towers, J. Chen, R. Gao, Y. Zhang, C. Yen, A. Lee, Y. Li, C. Zhou, K. Liu, J. Zhang, T. Gu, X. Chen, Z. Chang, D. Leung, S. Gao, Y. Jiang, W. Xie. “Isoform switch of TET1 regulates DNA demethylation and mouse development”. Molecular Cell, 2016. https://doi.org/10.1016/j.molcel.2016.10.030
6. W. Zhang, Y. Zhang. “TARSII and CARSII: Two approaches for SNP-independent identification of germline differentially methylated regions in mammals”. STAR Protocols, 2022. https://doi.org/10.1016/j.xpro.2022.101240
7. Q. Wang, G. Yu, X. Ming, W. Xia, X. Xu, Y. Zhang, W. Zhang, Y. Li, C. Huang, H. Xie, B. Zhu, W. Xie. (2019). “Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance”. Nature Genetics, 2019. https://doi.org/10.1038/s41588-020-0661-y
8. Y. Zhang, Y. Xiang, Q. Yin, Z. Du, X. Peng, Q. Wang, M. Fidalgo, W. Xia, Y. Li, Z. Zhao, W. Zhang, J. Ma, F. Xu, J. Wang, L. Li, W. Xie. “Dynamic epigenomic landscapes during early lineage specification in mouse embryos”. Nature Genetics, 2018. https://doi.org/10.1038/s41588-017-0003-x
9. Y. Li, H. Zheng, Q. Wang, C. Zhou, L. Wei, X. Liu, W. Zhang, Y. Zhang, Z. Du, X. Wang, W. Xie. “Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys”. Genome Biology, 2018. https://doi.org/10.1186/s13059-018-1390-8
10. A. Towers, M. Tremblay, L. Chung, X. Li, A. Bey, W. Zhang, X. Cao, X. Wang, P. Wang, P. Wang, L. Duffney, S. Siecinski, S. Xu, Y. Kim, X. Kong, S. Gregory, W. Xie, Y. Jiang. “Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders”. JCI insight, 2018. https://insight.jci.org/articles/view/120592
11. X. Ding, S. Liu, M. Tian, W. Zhang, T. Zhu, D. Li, J. Wu, H. Deng, Y. Jia, W. Xie, X. Hong, J. Guan. “Active-induced histone modifications govern Neurexin splicing and memory preservation”. Nature Neuroscience, 2017. https://doi.org/10.1038/nn.4536
12. J. Wu, B. Huang, H. Chen, Q. Yin, Y. Liu, Y. Xiang, B. Zhang, B. Liu, Q. Wang, W. Xia, W. Li, Y. Li, J. Ma, X. Peng, H. Zheng, J. Ming, W. Zhang, J. Zhang, G. Tian, F. Xu, Z. Chang, J. Na, X. Yang, W. Xie. “The landscape of accessible chromatin in mammalian preimplantation embryos”. Nature, 2016. https://doi.org/10.1038/nature18606
13. X. Xiong, T. Panchenoko, S. Yang, S. Zhao, P. Yan, W. Zhang, W. Xie, Y. Li, Y. Zhao, C. David Allis, H. Li. “Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2”. Nature Chemical Biology, 2016. https://doi.org/10.1038/nchembio.2218
14. L. Pan, W. Xie, K. Li, Z. Yang, J. Xu, W. Zhang, L. Liu, X. Ren, Z. He, J. Wu, J. Sun, H. Wei, D. Wang, W. Xie, W. Li, J. Ni, F. Sun. “Heterochromatin remodeling by CDK12 contributes to learning in Drosophila”. Proceedings of the National Academy of Sciences, 2015. https://doi.org/10.1073/pnas.1502943112