Dr. Krutika Patel

Vanderbilt University, USA

Email: Krutika.patel@vumc.org

Qualifications

2012-2016 Post-Doctoral Research Fellowship, Mayo Clinic, USA

2004-2010 MBBS, Grant Government Medical College, India

Publications (Selected)

1. Vela, A Guerra, G Farrell, S Trivedi, C Rood, R Singh, S Kostenko, Y Chang, C Snozek, K Patel, B Khatua, VP Singh. Pathophysiology and Biomarker Potential of Fatty Acid Ethyl Ester Elevation During Alcoholic Pancreatitis Gastroenterology. May 19, 2021. htps://doi.org/10.1053/j.gastro.2021.07.029.
2. Khatua B*, El-Kurdi B*, Patel KS*, Rood C, Noel P, Crowell M, Yaron J, Kostenko S, Guerra A, Faigel DO, Lowe M, Singh VP. Adipose Saturation Reduces Lipotoxic Systemic Inflammation and Explains the Obesity Paradox. Science Advances 29 Jan 2021: Vol. 7, no. 5, eabd6449 DOI:10.1126/sciadv.abd6449 *Joint First-Author; Equal Contribution.
3. De Oliveira C, Khatua B, El Kurdi B, Patel K, Mishra V, Navina S, Grim BJ, Gupta S, Belohlavek M, Cherry BR, Yarger J, Green MD, Singh VP. Thermodynamic Interference With Bile Acid Demicelleization Reduces Systemic Entry and Injury During Cholestasis. Scientific Reports (A Journal of the Nature Research family), Volume 10, Article number: 8462 (2020).
4. de Oliveira C, Khatua B, Noel P, Kostenko S, Bag A, Balakrishnan B, Patel KS, Guerra AA, Martinez MN, Trivedi S, McCullough A, Lam-Himlin DM, Navina S, Faigel DO, Fukami N, Pannala R, Phillips AE, Papachristou GI, Kershaw EE, Lowe ME, Singh VP. Pancreatic Triglyceride Lipase Mediates Lipotoxic Systemic Inflammation. The Journal of Clinical Investigation (JCI). 2020 ; 130(4):1931-1947. doi: 10.1172/JCI132767.
5. Krutika S. Patel, MBBS, MD; Safia N. Salaria, MD,FCAP. Hepatocellular carcinoma, moderately differentiated, grade II & III (Liver). 2021 PIP-B Performance Improvement Program in Surgical Pathology (CME eligible). © 2021 College of American Pathologists - CME Self-Assessment Module released June 2021.
6. Knowles KJ, Patel KS, Hameed N, Hague M, Xi H, Alzubaidi Y, Li A, Turbat-Herrera E. Rare and Unusual Tumors of the Head and Neck: Case Reports and Review of the Literature. Am J Otolaryngol Head Neck Surg. 2019; 2(8): 1066.
7. Khatua B, Trivedi RN, Noel P, Patel K, Singh R, de Oliviera C, Trivedi S, Mishra V, Lowe M, Singh VP. Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury During Severe Acute Pancreatitis. The American Journal of Pathology. Volume 189, Issue 6, June 2019, Pages 1226-1240.
8. de Oliveira C, Khatua B, El-Kurdi B, Patel K, Mishra V, Navina S, Gupta S, Belohlavek M, Green MD, Singh VP. Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival. Gastroenterology. February 2019. Volume 156, Issue 3, Pages 735–747.e10.
9. Faigel DO, Singh VP, Patel KS, Chami AE, Raymond CC, Landreth TL, Marler RJ, Lake DF,Kachaamy T. Safety of EUS-Guided Portal Injection Chemotherapy Using Drug-Eluting Microbeads in The Porcine Model. Journal of Cancer Research Updates. 2018, 7, 000-000. E-ISSN: 1929-2279/18.
10. de Oliveira C, Patel K, Mishra V, Trivedi R, Noel P, Singh A, Yaron JR, Singh VP. Characterization and Predictive Value of Near Infrared 2-Deoxyglucose Optical Imaging in Severe Acute Pancreatitis. PLos One. 11(2): e0149073.
11. Patel K, Durgampudi C, Noel P, Trivedi RN, de Oliveira C, Singh VP. Fatty Acid Ethyl Esters Are Less Toxic Than Their Parent Fatty Acids Generated During Acute Pancreatitis. The American Journal of Pathology. Vol. 186, Issue 4, p874–884.
12. Patel K, Trivedi RN, Durgampudi C, Noel P, Cline RA, DeLany JP, Navina S, Singh VP. Lipolysis of Visceral Adipocyte Triglyceride by Pancreatic Lipases Converts Mild Acute Pancreatitis to Severe Pancreatitis Independent of Necrosis and Inflammation. The American Journal of Pathology. Volume 185, Issue 3, 808 - 819.
13. Noel P*, Patel K*, Durgampudi C, Trivedi R, de Oliveira C, Crowell M, Pannala R, Lee K, Brand R, Chennat J, Slivka A, Papachristou GI, Khalid A, Whitcomb D, DeLany J, Cline R, Acharya C, Jaligama D, Murad F, Yadav D, Navina S, Singh VP. Unsaturated Fatty Acids Enriched in Human Pancreatic Necrosis Worsen Necrotizing Pancreatitis and Outcomes of Acute Pancreatitis Independent of Pancreatic Necrosis. Gut. 2016; 65:100-111 *Joint First-Author; Equal Contribution.
14. Mishra V, Patel K, Trivedi RN, Noel P, Durgampudi C, Acharya C, Holmes JA, Narla S, Singh VP. Hypothermia Slows Consecutive and Parallel Deleterious Steps Initiated in Pancreatitis. Pancreatology.Volume 14, Issue6, 459 – 464.
15. Durgampudi C*, Noel P*, Patel K*, Cline R, Trivedi RN, DeLany JP, Yadav D, Papachristou GI, Lee K, Acharya C, Jaligama D, Navina S, Murad F, Singh VP. Acute Lipotoxicity Regulates Severity of Biliary Acute Pancreatitis Without Affecting Its Initiation. The American Journal of Pathology. Volume 184, Issue 6, 1773 - 1784. *Joint First-Author; Equal Contribution.
16. Patel K, Noel P, Singh VP. Potential Influence of Intravenous Lipids on The Outcomes of Acute Pancreatitis. Nutrition in Clinical Practice. 2014 Jun;29(3):291-4.
17. Mishra V, Cline R, Noel P, Karlsson J, Baty CJ, Orlichenko L, Patel K, Trivedi RN, Husain SZ, Acharya C, Durgampudi C, Stolz DB, Navina S, Singh VP. Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of An Increase in Cytosolic Calcium. PLos One. 2013 Jun 18;8(6): e6647.
18. Acharya C, Cline RA, Jaligama D, Noel P, Delany JP, Bae K, Furlan A, Baty CJ, Karlsson JM, Rosario BL, Patel K, Mishra V, Durgampudi C, Yadav D, Navina S, Singh VP. Fibrosis Reduces Severity of Acute on Chronic Pancreatitis in Humans. Gastroenterology. 2013 Aug;145(2):466-75.