Dr. Elisabetta Mantuano

Research Scientist, University of California San Diego

Email: emantuano@health.ucsd.edu

Qualifications

1998 Pharm.D., University of Pisa, Italy

2004 Visiting Research Scholar., College of Pharmacy and Health Sciences, Butler University, Indianapolis Indiana

2007 Postdoctoral Fellow., Department of Anesthesiology and Pathology, UCSD

Publications (Selected)

1. Calderone V, Giorgi I, Livi O, Martinotti E, Mantuano E, Martelli A, Nardi A. Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII. European Journal of Medicinal Chemistry. 2005 Jun;40(6):521-8.
2. Gallo D, Mantuano E, Fabrizi M, Ferlini C, Mozzetti S, De Stefano I, Scambia G. Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer. Endocrine Related Cancer. 2007 Jun;14(2):317-24.
3. Gallo D, Battaglia A, Mantuano E, Travaglia D, De Stefano I, Buzzonetti A, Scambia G. 17beta-Estradiol and soy phytochemicals selectively induce a type 2 polarization in mesenteric lymph nodes of ovariectomized rats. Menopause. 2008 Jul-Aug;15(4 Pt 1):718-25.
4. Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL. Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. Journal of Biological Chemistry. 2008 Jul 18;283(29):19904-11
5. Gallo D, Zannoni GF, De Stefano I, Mosca M, Ferlini C, Mantuano E, Scambia G. Soy phytochemicals decrease non small cell lung cancer growth in female athymic mice. The Journal of Nutrition. 2008 Jul;138(7):1360-4.
6. Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of Schwann cells by binding to low-density lipoprotein receptor-related protein. Journal of Neuroscience. 2008 Nov 5;28(45):11571-82.
7. Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL. Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Science Signaling. 2009 Apr 28;2(68):ra18.
8. Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana WM. Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface. Glia. 2010 Mar;58(4):399-409.
9. Mantuano E, Jo M, Gonias SL, Campana WM. Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. Journal of Biological Chemistry. 2010 May 7;285(19):14259-66.
10. Mantuano E, Henry K, Yamauchi T, Hiramatsu H, Yamauchi K, Sumihisa O, Jonathan HL, Gonias SL, Campana WM. The Unfolded Protein Response is a Major Mechanism by which LRP1 Regulates Schwann Cell Survival After Injury. Journal of Neuroscience. 2011. Sep 21;31(38):13376-13385.
11. Capozzi A, Mantuano E, Matarrese P, Saccomanni G, Manera C, Mattei V, Gambardella L, Malorni W, Sorice M, Misasi R. A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis. Anti-Cancer Agents in Medicinal Chemistry. 2012. Jul 1;12(6):653-62
12. Stiles T, Dickendeshe T, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL. LDL Receptor-related Protein-1 is a sialic acid-independent receptor for myelin-associated glycoprotein (MAG) that functions in neurite outgrowth inhibition by MAG and CNS myelin. Journal of Cell Science. 2012 Nov 6
13. Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ichikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM. Schwann cell LRP1 regulates Remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. Journal of Neuroscience. 2013 Mar 27;33(13):5590-602.
14. Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM . Low-Density Lipoprotein Receptor Related protein-1 (LRP1)-Dependent Cell Signaling Promotes Neurotrophic Activity in Embryonic Sensory Neurons. PLoS One. 2013 Sept; 8(9):e75497.
15. Mantuano E, Lam MS, Gonias SL. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissuetype plasminogen activator and myelin-associated glycoprotein. Journal of Biological Chemistry. 2013 Nov 22;288(47):34009-18
16. Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE. Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One. 2013 Nov 27;8(11):e81081.
17. Mantuano E, Tasciotti V, Garofalo T, Sorice M, Misasi R, Mattei V. PrPC associates with a multimolecular complex including LRP1 and glycosphingolipids within lipid rafts. The FASEB Journal. 2014 vol. 28 no. 1 Supplement 601.1

Personal Website:

https://scholar.google.com/citations?user=bh4rVWEAAAAJ&hl=en&oi=ao