Dr. Ramkumar Srinivasagan

Case Western Reserve University, USA

Research Associate

Email: rxs787@case.edu

Qualifications

2014 Ph.D., Bharathidasan University, India

2009 M.Sc., Anna University, India

2007 B.Sc., Bharathidasan University, India

Publications (Selected)

1. Srinivasagan Ramkumar, Jean Moon, Marcin Golzack, Johhanes Von Lintig, Lrat co-ordiantes in the Negative feedback regulation of Intestinal retinoids biosynthesis from betacarotene 2021 Journal of Lipid Research
2. Zongbo Wei, Caili Hao, Jingru Huangfu, Ramkumar Srinivasagan,Xiang Zhang,Xingjun Fan Aging Lens Epithelium is Susceptible to Ferroptosis 2021, Free Radical biology and medicine
3. Sepalika Bandara, Linda D. Thomas, Srinivasagan Ramkumar, Nimesh Khadka, Philip D. Kiser, Marcin, Golczak, and Johannes von Lintig The structural and biochemical basis of apocarotenoid processing by β-carotene-oxygenase-2. 2021 ACS Chem Biol
4. Jennifer M Petrosino, Jacob Z. Longenecker, Srinivasagan Ramkumar, Xianyao Xu, Lisa E Dorn, Anna Bratasz, lianbo yu, Santosh Maurya, Vladimir Tolstikov, Valerie Bussberg, Paul M. Janssen, Muthu Periasamy, Michael Kiebish, Gregg Duester, Johannes von Lintig, Ouliana Ziouzenkova, Federica Accornero, 2021 Journal of Clinical Investigation
5. Linda D. Thomas, Vipul M. Parmar, Sepalika Bandara, Srinivasagan Ramkumar, Marcin Golczak, Philip D. Kiser and Johannes von Lintig The human mitochondrial enzyme BCO2 exhibits catalytic activity towards carotenoids and apocarotenoids, J Biol Chem. 2020 Sep 1
6. Wu L, Lyu Y, Srinivasagan R, Wu J, Ojo B, Tang M, El-Rassi GD, Metzinger K, Smith BJ, Lucas EA, Clarke SL, Chowanadisai W, Shen X, He H, Conway T, von Lintig J, Lin D.
7. Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice. J Nutr. 2020 Aug 18
8. Thomas LD, Ramkumar S, von Lintig J Expression and Characterization of Mammalian Carotenoid Cleavage Dioxygenases Methods Mol Biol. 2020;2083:75-88
9. von Lintig J, Moon J, Lee J, Ramkumar S. Carotenoid metabolism at the intestinal barrier Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Nov 30
10. Kelly, M., Ramkumar,S., Golczak, M., von Lintig, J, The Biochemical Basis of Vitamin A Production from Asymmetric Carotenoids. ACS Chem Biol. 2018 Jun 15
11. Srinivasagan Ramkumar, Xingjun Fan, Benlian Wang, Vincent M Monnier, Reactive cysteine residues in the oxidative dimerization and Cu 2+ induced aggregation of human γD-crystallin: Implications for age-related cataract BBA- Molecular basis of disease. 2018 Nov;1864(11):3595-3604
12. Widjaja-Adhi MAK, Ramkumar S, von Lintig J. Protective role of carotenoids in the visual cycle. FASEB J. 32, 000–000 (2018)
13. Zongbo Wei, Jane Caty, Jeremy whitson, Amy D. Zang, Ramkumar Srinivasagan, Terrance J. Kavanagh, Xinjgun fan. Chronic oxidative stress due to low glutathione levela promotes Wnt/β-catenin-mediated epithelial- mesenchymal transition in the lens: revelance for cataract therapy. American Journal of Pathology 2017;187:2399-2412
14. Thankappan B, Ramesh D, Ramkumar S, Natarajaseenivasan K, Anbarasu K. Characterization of Bacillus spp. from the gastrointestinal tract of Labeo rohita--towards to identify novel probiotics against fish pathogens. App Biochem Biotechnol 2015; 175:340-353
15. Kumari RP, RamkumarS, Thankappan B, Natarajaseenivasan K, Balaji S, Anbarasu K.Transcriptional regulation of crystallin, redox, and apoptotic genes by C-Phycocyanin in the selenite-induced cataractogenic rat model. Molecular vision 2015; 14: 26-39
16. Srinivasagan Ramkumar, Bency Thankappan, Noriko Fujii, Kalimuthusamy Natarajaseenivasan, Kumarasamy Anbarasu. Determination of the homogeneous and heterogeneous interaction of αA-crystallin F71L mutation – a mammalian two hybrid system approach. IJBM 2015;76: 102-8
17. Srinivasagan Ramkumar, Noriko Fujii, Hiroaki Sakaue, Norihiko Fujii, Bency Thankappan, Rasiah Pratheepa kumari, Kalimuthusamy Natarajaseenivasan, Kumarasamy Anbarasu. Real-Time Heterogeneous Protein-Protein Interaction between αA-Crystallin N-Terminal Mutants and αB-Crystallin using Quartz Crystal Microbalance (QCM) Amino Acid 2015; 47: 1035-43
18. Srinivasagan Ramkumar, Noriko Fujii, Norihiko Fujii, Bency Thankappan, Hiroaki Sakaue, Kim Ingu, Kalimuthusamy Natarajaseenivasan, Kumarasamy Anbarasu. Comparison of effect of gamma ray irradiation on wild-type and N-terminal mutants of αA-crystallin. Molecular Vision 2014; 20:1002-1016
19. Rai N, Chaubey G, Tamang R, Pathak AK, Singh VK, Karmin M, Singh M, Rani DS, Anugula S, Yadav BK, Singh A, Ramkumar Srinivasagan, Yadav A, Kashyap M, Narvariya S, Reddy AG, van Driem G, Underhill PA, Villems R, Kivisild T, Singh L, Thangaraj K. The phylogeography of Y-chromosome haplogroup h1a1a-m82 reveals the likely Indian origin of the European Romani populations. PLoS One. 2012;7(11):e48477

Profile Details

https://scholar.google.com/citations?user=rNoNj5AAAAAJ&hl=en

https://www.researchgate.net/profile/Ramkumar-Srinivasagan