Prof. Laura Ciapponi

Department of Biology and Biotechnologies

Sapienza University of Rome, Italy

Associate Prof. of genetics

Email: laura.ciapponi@uniroma1.it

Qualifications

Associate Professor of Genetics at Sapienza, University of Rome
Research associate position at the University of Rochester School of Medicine and Dentistry
Postdoctoral fellow, EMBL/Heidelberg (Germany)
PhD in Genetics and Molecular Biology, Sapienza, University of Rome

Publications (selected)

1. Maccallini P, Bavasso F, Scatolini L., Bucciarelli E., Noviello G., Lisi V., Palumbo V., Cacchione S., Cenci G., Ciapponi L., WakefieldJ, Gatti M. and Raffa GD Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development. PLOS GENETICS 2020.
2. Strah N., Romano G., Introna C., Klima R., Marzullo M., Ciapponi L., Megighian A., Nizzardo M. and Feiguin F. TDP-43 promotes the formation of neuromuscular synapses through the regulationof Disc-large in Drosophila skeletal muscles. BMC Biol. 2020; 18(1):34.
3. Bosso G, Cipressa F, Moroni ML, et al. NBS1 interacts with HP1 to ensure genome integrity. Cell Death Dis. 2019; 10(12):95.
4. Cicconi A., Micheli E., Vernì F., Jackson A., Gradilla A.C., Cipressa F., Raimondo D., Bosso G., Wakefield J.G., Ciapponi L., Cenci G., Gatti M., Cacchione S., Raffa G.D. The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response. Nucleic Acids Res. 2016.
5. D'Amico D., Antonucci L., Di Magno L., Coni S., Sdruscia G., Macone A., Miele E., Infante P., Di Marcotullio L., De Smaele E., Ferretti E., Ciapponi L., et al. Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth. Developmental Cell. 2015; 35: 21-35.
6. Cenci G., Ciapponi L., Marzullo M, Raffa G.D., Morciano P., Raimondo D., Burla R., Saggio I. and Gatti. The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres. Plos Genetics 2015.
7. Antonucci L., D’Amico D, Di Magno L., Coni S., Di Marcotullio L., Cardinali B., Gulino A., Ciapponi L. and Canettieri L. CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc. Cell Cycle 2013. 13:434-439.
8. Raffa G.D., Raimondo D., Sorino C., Cugusi S., Cenci G., Cacchione S., Gatti M. and Ciapponi L. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Genes & Development 2010; 24: 1596-1601.
9. Ciapponi L. and Cenci G. Telomere capping and cellular checkpoints: clues from fruit flies. Cytogenet Genome Res. 2008; 122: 365-373.
10. Somma M.P., Ceprani F., Bucciarelli E., Naim V., De Arcangelis V., Piergentili V., Palena A., Ciapponi L. et al. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Plos Genetics 2008; 4(7): e1000126.
11. Musarò M., Ciapponi L., Fasulo B., Gatti M. and Cenci G. Unprotected Drosophila telomeres activate the spindle assembly checkpoint. Nature Genetics 2008; 40: 362-366.
12. Ciapponi L., Cenci G., Ducau J., Flores C., Johnson-Schlitz D., Gorski M.M., Engels W.R., Gatti M. Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr Biol. 2004; 14:1360-1366.
13. Ciapponi L., Jackson D., Mlozik M., and Bohmann D. Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes & Development 2001; 15: 1540-1553.
14. Ciapponi L., Maione D., Scoumanne A., Costa P., Hansen M.B., Svenson M., Bendtzen K., Alonzi T., Paonessa G., Cortese R., Ciliberto G. and Savino R. Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nature Biotechnology 1997; 15: 997-1001.