Biography

Dr. Jinwei Zhang

University of Exeter Medical School, UK

Assistant Professor

Email: j.zhang5@exeter.ac.uk; jinweizhang01@gmail.com


Qualifications

2011 Ph.D., Newcastle University, UK

2007 M.Sc., Xiamen University, China

2003 B.Sc., Fujian Normal University, China.


Publications (Selected)

  1. Zhang J*, Zeng R*. Cloning, expression and characterization of the cold Active lipase (Lip3) from metagenomic DNA of an Antarctic deep-sea sediment. Progress in Biochemistry and Biophysics, 2006, 33(12):1207-1214.
  2. Zhang J, Lin S, Zeng R. Cloning, expression, and characterization of a cold-adapted lipase gene from an Antarctic deep-sea psychrotrophic bacterium, Psychrobacter sp. 7195. Journal of Microbiology and Biotechnology, 2007, 17 (4), 604.
  3. Zhang J, Zeng R. Purification and characterization of a cold-adapted α-Amylase produced by Nocardiopsis sp. 7326 isolated from Prydz Bay, Antarctic. Marine Biotechnology, 2008 Jan-Feb; 10(1):75-82.
  4. Zhang J*, Zeng R. Molecular cloning and expression of an extracellular α-amylase gene from an Antarctic deep sea psychrotolerant Pseudomonas stutzeri strain 7193. World Journal of Microbiology and Biotechnology, 2011 Apr, 27(4): 841-850.
  5. Zhang J, Zhang E, Scott K, Burgess JG. Enhanced electricity production using reconstituted artificial consortia of estuarine bacteria grown as biofilms. Environmental Science and Technology, 2012 Mar 6;46(5):2984-92. doi: 10.1021/es2020007.
  6. Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, Wilson-Delfosse AL, Chen SG. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Human Molecular Genetics, 2013 Jan 15;22(2):328-344. doi: 10.1093/hmg/dds431.
  7. de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J*. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. Biochemical Journal, 2014 Mar 15;458(3):559-573. doi: 10.1042/BJ20131478.
  8. Hatcher JM#, Zhang J#, Choi HG, Ito G, Alessi DR, Gray NS. Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective and Brain Penetrant LRRK2 Inhibitor. ACS Medicinal Chemistry Letters, 2015 Apr 7;6(5):584-9. doi: 10.1021/acsmedchemlett.5b00064.
  9. Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM. Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal PINK1‐dependent phosphorylation and activation. EMBO Reports, 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352.
  10. Emami K, Nelson A, Hack E, Zhang J, Green DH, Caldwell GS, Mesbahi E. MALDI-TOF mass spectrometry discriminates known species and marine environmental isolates of Pseudoalteromonas. Frontiers in Microbiology, 2016 Feb 12;7:104. doi: 10.3389/fmicb.2016.00104.
  11. Zhang J*, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT. Functional kinomics identifies a key regulatory module of swelling-regulated Cl- transport in the mammalian brain. Scientific Reports, 2016 6, 35986; doi: 10.1038/srep35986.
  12. Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. WNK kinase signaling in ion homeostasis and human disease. Cell Metabolism, 2017, Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007.
  13. Dumon C, Diabira D, Chudotvorova I, Bader F, Sahin S, Zhang J, Porcher C, Wayman G, Medina I, Gaiarsa JL. The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice. eLife, 2018 Aug 14;7. pii: e36726. doi: 10.7554/eLife.36726.
  14. Zhang J*. LRRK2 signalling pathways in Parkinson’s disease. Review. Archives in Neurology & Neuroscience. 2(4): 2019. ANN. MS.ID.000541. DOI: • 10.33552/ANN.2019.02.000540.
  15. Wantanabe M#, Zhang J#, Duan J, Mansuri M, Delpire E, Lifton RP, Alper SL, Fukuda1 A, Kahle KT. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Science Signalling, 2019, Oct 15;12(603). pii: eaaw9315. doi: 10.1126/scisignal.aaw9315.
  16. Pisella L, Gaiarsa JL, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I. Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Science Signalling, 2019 Oct 15;12(603). pii: eaay0300. doi: 10.1126/scisignal.aay0300.
  17. Zhang J*, Bhuiyan MIH, Zhang T, Karimy J, Wu Z, Pigott VM, Zhang J, Huang H, Hassan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, Hitchens TK, Minnigh M, Poloyac S, Alper SL, Molyneaux BJ, Trevelyan A, Kahle K*, Sun D*, Deng X*. Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications, 2020 Jan 7;11(1):78. doi: 10.1038/s41467-019-13851-6.
  18. Zhang J, Cordshagen A, Medyna I, Nothwang HG, Wisniewski JR, Winklhofer M, Hartmann AM. Staurosporine and NEM mainly impairs WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1. PLOS ONE. 2020 May 15;15(5):e0232967. doi: 10.1371/journal.pone.0232967.
  19. Brown A, Meor Azlan NF, Wu Z, Zhang J*. WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension. Acta Pharmacologica Sinica. 2020 Jul 28. doi: 10.1038/s41401-020-0474-7.
  20. Robert SM, Benjamin CR, Alper SL, Zhang J, Kahle KT. New drugs on the horizon for cerebral edema: what’s in the clinical development pipeline? Expert Opinion on Investigational Drugs. 2020. Oct;29(10):1099-1105. doi: 10.1080/13543784.2020.1813715.
  21. Meor Azlan NF, Koeners M, Zhang J*. Regulatory control of the Na-Cl co-transporter (NCC) and its therapeutic potential for hypertension. Acta Pharmacologica Sinica–B, 2020, https://doi.org/10.1016/j.apsb.2020.09.009.
  22. Delmotte Q, Medina I, Hamze M, Buhler E, Zhang J, Belgacem YH, Porcher C. Sonic. Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex. Journal of Cell Science. 2020 Sep 28;jcs.247700. doi: 10.1242/jcs.247700.
  23. Meor Azlan NF, Zhang J*. Role of the cation-chloride-cotransporters in cardiovascular disease. Cells 2020, Oct 14;9(10):E2293. doi: 10.3390/cells9102293.
  24. Salihu S, Meor Azlan NF, Josiah S, Wu Z, Wang Y, Zhang J*. Role of the cation-chloride-cotransporters in the circadian system. Asian Journal of Pharmaceutical Sciences, 2020 https://doi.org/10.1016/j.ajps.2020.10.003.
  25. Andrews K, Josiah S, Zhang J*. The therapeutic potential of neuronal K-Cl co-transporter KCC2 in Huntington’s disease and its comorbidities. International Journal of Molecular Science, 2020, 21(23), 9142; https://doi.org/10.3390/ijms21239142


Profile Details

https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Jinwei_Zhang.


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