Dr. Sean James Miller

Pluripotent Diagnostics Corp., USA

Founder

Email: sean@pluripotentdiagnostics.com

Qualifications

2019 Post-Doctoral Research Fellow, Neurology, Stanford University School of Medicine, USA

2018 Ph.D., Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, USA

2011 B.Sc., Organismal Physiology, Drexel University, Philadelphia, USA

Publications (selected)

1. Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. (2020) Upregulation of Alzheimer’s Disease Amyloid-β Protein Precursor in Astrocytes Both in Vitro and in Vivo’. Journal of Alzheimer’s Disease, 1071–1082.
2. Miller SJ, Philips T, Namho K, Dastagheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD (2019) Molecular defined cortical astroglia subpopulation modulatesneurons via secretion of Norrin. Nature Neuroscience, 22(5):741-752.
3. Miller SJ. (2018) Astrocyte heterogeneity in the adult central nervous system. Frontiers in Cellular Neuroscience, 12:401.
4. Choi S, Lee S, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, Praag HV, Spiegelman BM, Gage DH, Tanzi RE. (2018) Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. Science, 361(6406).
5. Efteharzadeh B*, Daigle JG*, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennet RE, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Martens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. (2018) Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease. Neuron, 99(5), 925-940.
6. Miller SJ, Glatzer JC, Hsieh YC, Rothstein JD. (2018) Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model. Journal of Neurogenetics, 32(4), 322-335.
7. Miller SJ, Rothstein JD. (2018) Generation of 3D printed biological imold for optically transparent specimens. Journal of Visualized Experiments (JoVE).
8. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. (2017) Soluble gamma-secretase modulators attenuate Alzheimer’s beta- amyloid pathology and induce conformational changes in Presenilin. EBioMedicine, 24, 93-101.
9. Miller SJ, Zhang PW, Glatzer JC, Rothstein JD. (2016) Astroglia transcriptome in early disease of an ALS mutant SOD1 mouse model. Journal of Neurogenetics, 31(1-2):37-48.
10. Zhang K*, Donnelly C*, Haeusler A, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. (2015) The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature, 525(7567), 56-61.