Prof. Alessandro Poggi

Molecular Oncology and Angiogeensis Unit

IRCCS Ospedale Policlinico San Martino, Italy

Professor for Clinical pathology, Molecular Oncology and Immunology

Email: alessandro.poggi@hsanmartino.it

Qualifications

2000 M.D., University of Genoa, Italy

1982 M.Sc., University of Genoa, Italy

Publications (Selected)

1. Zocchi MR, Tosetti F, Benelli R, Poggi A. Cancer Nanomedicine Special Issue Review Anticancer Drug Delivery with Nanoparticles: Extracellular Vesicles or Synthetic Nanobeads as Therapeutic Tools for Conventional Treatment or Immunotherapy. Cancers (Basel). 2020 Jul 13; 12(7): E1886. doi: 10.3390/cancers12071886. PMID: 32668783.
2. Di Mascolo D, Varesano S, Benelli R, Mollica H, Salis A, Zocchi MR, Decuzzi P, Poggi A. Nanoformulated Zoledronic Acid Boosts the Vδ2 T Cell Immunotherapeutic Potential in Colorectal Cancer. Cancers (Basel). 2019 Dec 31; 12(1). pii: E104. doi: 10.3390/cancers12010104. PMID: 31906080
3. Poggi A, Benelli R, Venè R, Costa D, Ferrari N, Tosetti F, Zocchi MR. Human Gut-Associated Natural Killer Cells in Health and Disease. Front Immunol. 2019 May 3; 10: 961. doi: 10.3389/fimmu.2019.00961. eCollection 2019. Review. PMID: 31130953.
4. Varesano S, Zocchi MR, Poggi A. Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures. Front Immunol. 2018 May 8; 9: 998. doi: 10.3389/fimmu.2018.00998. eCollection 2018. Erratum in: Front Immunol. 2018 Jun 13; 9: 1343.
5. Pereira RC, Martinelli D, Cancedda R, Gentili C, Poggi A. Human Articular Chondrocytes Regulate Immune Response by Affecting Directly T Cell Proliferation and Indirectly Inhibiting Monocyte Differentiation to Professional Antigen-Presenting Cells. Front Immunol. 2016 Oct 24; 7: 415. PMID: 27822208.
6. Zocchi MR, Camodeca C, Nuti E, Rossello A, Venè R, Tosetti F, Dapino I, Costa D, Musso A, Poggi A. ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing. Oncoimmunology. 2015 Dec 29; 5(5): e1123367. doi: 10.1080/2162402X.2015.1123367. eCollection 2016 May.
7. Poggi A, and ZocchiMR. NK cell autoreactivity and autoimmune diseases. Front Immunol. 2014 Feb 4; 5: 27. doi: 10.3389/fimmu.2014.00027. eCollection 2014. Review
8. Musso A., Catellani S., Canevali P., Tavella S., Venè R., Boero S., Pierri I., Gobbi M., Kunkl A., Ravetti J-L, Zocchi MR. and Poggi A. Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vdelta 2 T lymphocytes in non-Hodgkin lymphomas. Haematologica/the Hematology Journal, 2014 Jan; 99(1): 131-9. doi: 10.3324/haematol.2013.097311. Epub 2013 Oct 25.
9. MR Zocchi, S. Catellani, P. Canevali, S. Tavella, A. Garuti, B. Villaggio, A. Zunino, M. Gobbi, Giulio Fraternali-Orcioni, Annalisa Kunkl, Jean-Louis Ravetti, Silvia Boero, Alessandra Musso, and Alessandro Poggi. High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D-Ligands recognition in Hodgkin lymphomas. Blood, 2011 Dec 13.
10. Musso A., Zocchi MR., and Poggi. A. Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T cell proliferation and B cell survival. Haematologica, 2011 Jan; 96(1): 16-23. Epub 2010 Sep 30.
11. Poggi A., S. Catellani, A. Garuti, I. Pierri, M. Gobbi, and M. R. Zocchi. Effective in vivo induction of NKG2D ligands in acute myeloid leukemias by all-transretinoic acid and sodium valproate. Leukemia. 2009 Jan 8.
12. Poggi A., Catellani S., Bruzzone A., Caligaris-Cappio F., Gobbi M. and Zocchi M.R. Lack of the Leukocyte-associated Ig-like receptor-1 expression in high risk chronic lymphocytic leukemias results in the absence of a negative signal regulating kinase activation and cell division. Leukemia. 2008 May; 22(5): 980-8. Epub 2008 Feb 21.
13. Prevosto C, Zancolli M, Canevali P, Zocchi MR, Poggi A. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica. 2007 Jul; 92(7): 881-8.
14. Contini P, Zocchi MR, Pierri I, Albarello A, Poggi A. In vivo apoptosis of CD8(+) lymphocytes in acute myeloid leukemia patients: involvement of soluble HLA-I and Fas ligand. Leukemia. 2007 Feb; 21(2): 253-60. Epub 2006 Dec 14.
15. Poggi A., S. Negrini, M.R. Zocchi, A-M Massaro, L. Gargiulo, R. Notaro and L. Luzzatto. Patients with Paroxysmal Nocturnal Hemoglobinuria have a high frequency of peripheral blood T cells expressing activating isoforms of Inhibiting Superfamily Receptors. Blood 2005, 106: 2399-2408.
16. Poggi A, Venturino C, Castellani S., Clavio M., Miglino M., Gobbi M., Steinle A.,Ghia P., Stella S., Caligaris Cappio F., and Zocchi MR. V1 T lymphocytes from B-CLL patients recognise ULBP3 expressed on leukemic B cells and upregulated by transretinoic acid. Cancer Research 2004, 64: 9172-9179.
17. Poggi A, Carosio R, Fenoglio D, Brenci S, Murdaca G, Setti M, Indiveri F, Scabini S, Ferrero E, Zocchi MR. Migration of V{delta}1 and V{delta}2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1 infected patients: competition by HIV-1 TAT. Blood. 2003 Nov 20.
18. Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A. Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Blood 2002 Dec 1; 100(12): 4098-107.
19. Spaggiari GM, Contini P, Carosio R, Arvigo M, Ghio M, Oddone D, Dondero A, Zocchi MR, Puppo F, Indiveri F, Poggi A. Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood 2002 Mar 1; 99(5): 1706-14.
20. Poggi A, Sargiacomo M, Biassoni R, Pella N, Sivori S, Revello V, Costa P, Valtieri M, Russo G, Mingari MC, et al. Extrathymic differentiation of T lymphocytes and natural killer cells from human embryonic liver precursors. Proc Natl Acad Sci U S A 1993 May 15; 90(10): 4465-9.
21. Poggi A, Biassoni R, Pella N, Paolieri F, Bellomo R, Bertolini A, Moretta L, Mingari MC. In vitro expansion of CD3/TCR-human thymocyte populations that selectively lack CD3 delta gene expression: a phenotypic and functional analysis. J Exp Med 1990 Nov 1; 172(5): 1409-18.