University of Kentucky, USA

Research Associate

Email: ppratheeshkumar@gmail.com

Qualifications

2011    Ph.D.,  Mahatma Gandhi University, Immunology

2007    M.Phil., Bharathidasan University, Biotechnology

Publications (Selected)

1. Son YO, Pratheeshkumar P, Divya SP, Zhang Z, Shi X. Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells. J Biol Chem. 2017 May 19; 292(20):8315-8330.
2. Siraj AK, Masoodi T, Bu R, Pratheeshkumar P, Al-Sanea N, Ashari LH, Abduljabbar A, Alhomoud S, Al-Dayel F, Alkuraya FS, Al-Kuraya KS. MED12 is recurrently mutated in Middle Eastern colorectal cancer. Gut. 2017 Feb 9. pii: gutjnl-2016-313334.
3. Pratheeshkumar P, Son YO, Divya SP, Wang L, Zhang Z, Shi X. Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism. Sci Rep. 2016 Nov 23; 6:37227.
4. Wang L, Fan J, Hitron JA, Son YO, Wise JT, Roy RV, Kim D, Dai J, Pratheeshkumar P, Zhang Z, Shi X. Cancer stem-like cells accumulated in nickel-induced malignant transformation. Toxicol Sci. 2016 Jun; 151(2):376-87.
5. Roy RV, Pratheeshkumar P, Son YO, Wang L, Hitron JA, Divya SP, Zhang Z, Shi X. Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells. Toxicol Appl Pharmacol. 2016 Sep 15; 307:81-90.
6. Kim D, Dai J, Park YH, Fai LY, Wang L, Pratheeshkumar P, Son YO, Kondo K, Xu M, Luo J, Shi X, Zhang Z. Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium. J Biol Chem. 2016 Jul 29; 291(31):16271-81.
7. Pratheeshkumar P, Son YO, Divya SP, Turcios L, Roy RV, Hitron JA, Wang L, Kim D, Dai J, Asha P, Zhang Z, Shi X. Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling. Oncotarget. 2016 Aug 9; 7(32):51193-51210.
8. Pratheeshkumar P, Son YO, Divya SP, Wang L, Turcios L, Roy RV, Hitron JA, Kim D, Dai J, Asha P, Zhang Z, Shi X. Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway. Oncotarget. 2016 Jun 17; 8(32):52118-52131.
9. Son YO, Pratheeshkumar P, Roy RV, Hitron JA, Wang L, Divya SP, Xu M, Luo J, Chen G, Zhang Z, Shi X. Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis. J Biol Chem. 2015 Nov 6; 290(45):27090-100.
10. Wang L, Hitron JA, Wise JT, Son YO, Roy RV, Kim D, Dai J, Pratheeshkumar P, Zhang Z, Xu M, Luo J, Shi X. Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-κB signalings in colorectal cancer cells. Toxicol Appl Pharmacol. 2015 Oct 15; 288(2):232-9.
11. Divya SP, Pratheeshkumar P, Son YO, Roy RV, Hitron JA, Kim D, Wang L, Dai J, Asha P, Shi X, Zhang Z. Arsenic induces insulin resistance in mouse adipocytes and myotubes via the oxidative stress regulated mitochondria dependent SIRT3-FOXO3a signaling pathway. Toxicol Sci. 2015 Aug; 146(2):290-300.
12. Divya SP, Wang X, Pratheeshkumar P, Son YO, Roy RV, Hitron JA, Kim D, Wang L, Dai J, Asha P, Shi X, Zhang Z. Blackberry extract inhibits UVB-induced oxidative damage and inflammation and regulate MAP kinases and NF-κB signalling pathways in SKH-1 mice skin. Toxicol Appl Pharmacol. 2015 Apr 1; 284(1):92-9.
13. Kim D, Dai J, Fai LY, Yao H, Son YO, Wang L, Pratheeshkumar P, Zhang Z. Constitutive activation of epidermal growth factor receptor promotes Cr(VI)-induced tumorigenesis through decrease of reactive oxygen species and development of apoptosis resistance. J Biol Chem. 2015 Jan 23; 290(4):2213-24.
14. Zhang Z, Pratheeshkumar P, Son YO, Kim D, Shi X. Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells. Biochem Biophys Res Commun. 2015 Jan 9; 456(2):643-8.