Dr. Mohammad Shahnawaz

Mitchell Center for Alzheimer's Disease and Related Brain Disorders

University of Texas Health Science Center at Houston, USA

Email: Mohammad.Shahnawaz@uth.tmc.edu

Qualifications

2004-2008   PhD (Protein Biochemistry); Chosun University, Republic of Korea

1999-2001   Master of Science (Biochemistry); Jiwaji University, India

1991-1994   Bachelor of Science (Chemistry); Magadh University, India

Publications (Selected)

1. Shahnawaz M, Takahiko Tokuda, Masaaki Waragai, Nicolas Mendez, Ryotaro Ishii, Claudia Trenkwalder, Brit Mollenhauer  and Claudio Soto. Biochemical diagnosis of Parkinson's disease by detection of α-synuclein misfolded aggregates in cerebrospinal fluid. JAMA Neurology. 2016 Dec 5. doi: 10.1001/jamaneurol.2016.4547
2. Moreno-Gonzalez, I., Edwards, G., Salvadores, N., Shahnawaz, M., Diaz-Espinoza, R. and Soto, C. (2016) Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding. Molecular Psychiatry (In press).
3. Shahnawaz M, Kyung-won Park, Rodrigo Diaz-Espinoza and Soto C. Prion-like Characteristics of the bacterial protein Microcin E492. Scientific Reports (In Press).
4. Salvadores N*, Shahnawaz M*, Scarpini E, Tagliavini F, Soto C. Detection of Misfolded Aβ Oligomers for Sensitive Biochemical Diagnosis of Alzheimer's Disease. Cell Reports. 2014 Mar 18. pii: S2211-1247(14)00145-4.
5. Sharoar MG, Islam MI, Shahnawaz M, Shin SY, Park IS. Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway. Biochim Biophys Acta. 2014 Apr; 1843(4):685-93.
6. Shahnawaz M, Sharoar MG, Shin SY, Park IS.Wild-type, Flemish, and Dutch amyloid-β exhibit different cytotoxicities depending on Aβ40 to Aβ42 interaction time and concentration ratio. J Pept Sci. 2013 Sep; 19(9):545-53.
7. Sharoar MG1, Shahnawaz M, Islam MI, Ramasamy VS, Shin SY, Park IS.The inhibitory effects of Escherichia coli maltose binding protein on β-amyloid aggregation and cytotoxicity. Arch Biochem Biophys. 2013 Oct 1; 538 (1):41-8
8. Sharoar MG, Thapa A, Shahnawaz M, Ramasamy VS, Woo ER, Shin SY, Park IS. Keampferol-3 O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates. J Biomed Sci. 2012 Dec 21; 19:04. doi: 10.1186/1423-0127-19-104.
9. Shahnawaz M, Soto Claudio. Microcin amyloid fibrils are a reservoir of toxic oligomeric species. Journal of Biological Chemistry. 2012 Apr 6; 287 (15):11665-76.
10. Thapa A *, Shahnawaz M*, Karki P, Raj Dahal G, Golam Sharoar M, Yub Shin S, Sup Lee J, Cho B, Park IS. Purification of inclusion body-forming peptides and proteins in soluble form by fusion to Escherichia coli thermostable proteins. Biotechniques. 2008 May; 44(6):787-96
11. Dahal GR, Karki P, Thapa A, Shahnawaz M, Shin SY, Lee JS, Cho B, Park IS. Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD).Arch Biochem Biophys. 2007 Dec 1;468(1):134-9. Epub 2007 Sep 19.
12. Shahnawaz M *, Thapa A*, Park IS. Stable activity of a deubiquitylating enzyme (Usp2-cc) in the presence of high concentrations of urea and its application to purify aggregation-prone peptides Biochem Biophys Res Commun. 2007 Aug 3; 359(3):801-5. Epub 2007 Jun 4.
13. Ashraf S, Singh PK, Yadav DK, Shahnawaz M, Mishra S, Sawant SV, Tuli R. High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice. J Biotechnology. 2005 Sep 22; 119(1):1-14.