Prof. Samy L. Habib

The University of Texas Health Science Center at San Antonio, USA

Email: Habib@uthscsa.edu

Qualifications

1993 Ph.D., Roswell Park Cancer Institute, Buffalo, NY.

1986 M.S., University of Alexandria, Alex

1981  B.S., University of Alexandria, Alex

Publications (Selected)

1. Habib SL, Al-Obaidi, Nowacki M, Drewa T, Medina E, Zhao Z and Liang S. Is mTOR inhibitor good enough for treatment all tumors in TSC Patients? J Cancer. In Press. 2016
2. Habib SL, Sumathy Mohan, Sitai Liang, Baojie Li and Mukesh Yadav. Novel mechanism of transcription regulation of cell matrix protein in diabetes. Cell Cycle. 2015,14:2598-2608.
3. Marek Wiśniewski, Karolina Werengowska-Ciecwierz, Katarzyna Roszek, Joanna Czarnecka, Tomasz Kloskowski, Dominik Tyloch, Robert Debski, Katarzyna Pietkun, Marta Pokrywczyńska, Dariusz Grzanka, Rafał Czajkowski, Gerard Drewa, JosephAgyin, Habib SL, Artur Terzyk, Tomasz Drewa. Nanovehicles as a novel target strategy for hyperthermic intraperitoneal chemotherapy: A multidisciplinary study of peritoneal carcinomatosis. Oncotarget. 2015, 6:22776-22798.
4. Manickam Krishnan, Preethi Janardhanan, Linda Roman, Robert Reddick, Mohan Natarajan, Rien van Haperen, Habib SL, and Sumathy mohan. Enhancing eNOS activity with simultaneous inhibition of IKKβ restores vascular function in Ins2Akita /- type-1 diabetic mice. Laboratory Investigation. 2015, 6:1-13.
5. Xinsen Ruan, Qiao Zuo, Jia H, J Chua J, Lin J, Junping Ao, Xuechun Xia, Huijuan Liu, Habib SL, Chuangang Fu, and Baojie Li. p53 deficiency-induced Smad1 up-regulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers. Journal of Molecular Cell Biology 2015, 7: 105-118.
6. Mohan Natarajan, Ryszard Konopinski, Manickam Krishnan, Linda Roman, Alakesh Bera, Hongying Zheng, Habib SL, and Sumathy Mohan. Inhibitor kappa B kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells. American Journal of Physiology - Cell Physiology. 2015, 308: C673-83.
7. Adam Kosti, Hung-I Harry Chen, Mohan S, Sitai Liang, Yidong Chen and Habib SL. Microarray profile of human kidney from diabetes, renal cell carcinoma and renal cell carcinoma with diabetes. Genes and Cancer. 2015, 6: 62-70.
8. Jia H, Cong Q, Fung J, Chua L, Liu H, Xia X, Zhang X, Lin J, Habib SL, Ao J, Zuo Q, Fu C and Li B. p57Kip2 is an unrecognized DNA damage response effector molecule that functions in tumor suppression and chemoresistance. Oncogene. 2015, 34:3568-3581.
9. Liang S, Salas T, Gencaslan E, Li B and Habib SL. Tuberin-deficiency downregulates N-cadherin and upregulates vimentin in kidney tumor of TSC patients. Oncotarget. 2014, 5:6936-6946.
10. Habib SL. Tuberin in renal Cell Hypertrophy. Cell Cycle 2014,13: 869-870.
11. Habib SL and Sitai Liang. Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes. Oncotarget. 2014,15: 2542-2550.
12. Habib SL. Alterations in Tubular Epithelial Cells in Diabetic Nephropathy. Journal of Nephrology, 2013, 26: 865-869.
13. Sitai Liang, Gabriela Cuevas, Shaza Tizani, Tiffanie Salas, Huijuan Liu, Baojie Li and Habib SL. Novel Mechanism of Regulation of Fibrosis in Kidney Tumor of Tuberous Sclerosis. Molecular Cancer. 2013, 12: 1-11.
14. Queisser N, Habib SL and Nicole Schupp. High blood pressure influence aldosterone to induce oxidative stress and DNA damage. Free Radical Biology & Medicine. 2013, 54:17-25.
15. Habib SL, Yadav M, Tizani S, Bhandari B, Valente AJ. Tuberin Inhibits Production of the Matrix Protein Fibronectin in Diabetes. J Am Soc Nephrology. 2012, 23:1652-1662.
16. Habib SL, Thomas J Prihoda, Maria Luna and Sherry A Werner. Diabetes and Risk of Renal Cell Carcinoma. Journal of Cancer. 2012, 3:42-48.
17. Habib SL. Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells. Oncotarget, 2011, 2: 958-959.
18. Habib SL, Yadav A, Mahimainathan L, Valente AJ. Regulation of PI 3-K, PTEN, p53, and mTOR in Malignant and Benign Tumors Deficient in Tuberin. Genes and Cancer. 2011, 2:1051-1060.
19. Habib SL. Tuberin and mTOR, a key apoptotic pathway in diabetes. Cell Cycle 2011, 10: 2237-2238.
20. Velagapudi C, Bhandari BS, Abboud-Werner S, Simone S, Abboud HE, Habib SL. The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes. Journal of the American Society of Nephrology. 2011; 22:262-273.
21. Lai KP, Leong WF, Chau JF, Jia D, Zeng L, Liu H, He L, Hao A, Zhang H, Meek D, Velagapudi C, Habib SL, Li B. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. The European Molecular Biology Organization Journal 2010, 30:1-13.
22. Habib SL, Kasinath BS, Arya R, Vexler S, Velagapudi C. Novel Mechanism of Reducing Tumorigenesis: Upregulation of the DNA Repair Enzyme OGG1 by Rapamycin-Mediated AMPK Activation and mTOR Inhibition. European J Cancer. 2010, 46:2806-2820.
23. Habib SL Bhandari BK, Sadek N, Abboud-Werner SL, Abboud HE. Novel Mechanism of Regulation of the DNA repair enzyme OGG1 in Tuberin-deficient Cells. Carcinogenesis. 2010; 31:2022-2030.
24. Habib SL. TSC diseases and DNA repair. Adv Exp Med Biol. 2010, 685:84-94.
25. Habib SL. Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA. J Molecular Signaling, 2009, 4:8-11.
26. Mahimainathan L, Venkatesan B, Das F, Habib SL, Ghosh-Choudury N, Kasinath BS, Abboud HE and Ghosh-Choudhury G. TSC2 deficiency increases pten via HIF1alpha. Journal of Biological Chemistry 2009, 284:27790-22798.
27. Habib SL. Insights into mechanisms of oxidative DNA damage in angomyolipomas from TSC patients. Molecular Cancer, 2009; 8:1-10.
28. Ye P, Habib SL, Ricono JM, Kim NH, Choudhury GG, Barnes JL, Abboud HE, Arar MY. Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation. Kidney International 2004, 66:1356-1364.
29. Habib SL, Phan MN, Patel SK, Li D, Monks TJ, Lau SS. Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis 2003, 24: 573-582.