Biocatalysis and Metabolic Engineering

Rensselaer Polytechnic Institute, USA

Professor

Email: linhar@rpi.edu

Qualifications

1979 Ph.D., The Johns Hopkins University, Organic Chemistry

1977 M.A., The Johns Hopkins University, Organic Chemistry

1975 B.S., Marquette University, Chemistry

Publications (selected)

1. "Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor•fibroblast growth factor receptor complexes," F. Zhang, Z. Zhang, X. Lin, A. Beenken, A. V. Eliseenkova, M. Mohammadi, R. J. Linhardt, Biochemistry, 48, 8379–8386, 2009.
2. "Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparin," J. Han, F. Zhang, J. Xie, R. J. Linhardt and L. M. Hiebert, Cardiovascular Diabetology, 8, 46-58, 2009.
3. "Photolytic depolymerization of alginate," J. Burana-osot, S. Hosoyama, Y. Nagamoto, S. Suzuki, R. J. Linhardt, T. Toida, Carbohydrate Research, 344, 2023–2027, 2009.
4. "Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE," Z. Zhang, B. Li, J. Suwan, F. Zhang, Z. Wang, H. Liu, B. Mulloy, R. J. Linhardt, Journal of Pharmaceutical Science, 98, 4017-4026, 2009.
5. "Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans," H-J Ra, S. Harju-Baker, F. Zhang, R. J. Linhardt, C. L. Wilson, W. C. Parks, Journal of Biological Chemistry, 284, 27924-27932, 2009.
6. "Orthogonal analytical approaches to detect potential contaminants in heparin," M. Guerrini, Z. Zhang, Z. Shriver, S. Masuko, R. Langer, B. Casu, R. J. Linhardt, G. Torri, R. Sasisekharan, Proceedings of the National Academy of Sciences USA, 106, 16956–16961, 2009.
7. "Gold and silver nanoparticles conjugated with heparin-derivative possess anti-angiogenesis properties," M. M. Kemp, A. Kumar, S. Mousa, E. Dyskin, M. Yalcin, P. Ajayan, R. J. Linhardt, S.A. Mousa, Nanotechnology, 20, 455104, 2009.
8. "Recent progress and applications in glycosaminoglycan and heparin research," T. N. Laremore, F. Zhang, J. S. Dordick, J. Liu, R. J. Linhardt, Current Opinions in Chemical Biology, 13, 633–640, 2009.
9. "Enzymatic polymerization of phenols in room-temperature ionic liquids," B. Eker, D. Zagorevski, G. Zhu, R.J. Linhardt, J.S. Dordick, Journal of Molecular Catalysis B: Enzymatic, 59, 177–184, 2009.
10. "Cellulose composites prepared using ionic liquids (ILs)-Blood compatibility to batteries," T.-J. Park , S. Murugesan, R. J. Linhardt, Kevin Edgar, Thomas Heinze, Charles Buchanan (eds.), ACS symposium Series, Polysaccharide Materials: Performance by Design, Chapter 7, 133-152, 2009.
11. "Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate," S. Bhattacharyya, K. Solakyildirim Z. Zhang, R. J. Linhardt, J. K. Tobacman, American Journal of Respiratory Cell and Molecular Biology, 42, 51-61, 2010.
12. "Ultraperformance liquid chromatography with electrospray ion trap mass spectrometry for chondroitin disaccharide analysis," K. Solakyildirim, Z. Zhang, R. J. Linhardt, Analytical Biochemistry, 397, 24–28, 2010.
13. "Heparin-based nanoparticles," M. M. Kemp and R. J. Linhardt, Nanomedicine and Nanobiotechnology, 2, 77–87, 2010.
14. "NMR quantification for monitoring heparosan K5 capsular polysaccharide production," Z. Wang, Z. Zhang, S. A. McCallum, R. J. Linhardt, Analytical Biochemistry, 398, 275–277, 2010.
15. "Glycosaminoglycans from earthworms (Eisenia andrei)," A.-R. Im, Y. Park, J.-S. Sim, Z. Zhang, Z. Liu, R. J. Linhardt, Y. S. Kim, Glycoconjugate Journal, 27, 249–257, 2010.
16. "Unnatural polyketide analogs selectively target the HER2 signaling pathway in human breast cancer cells," S. J. Kwon, M. Kim, B. Ku, L. Coulombel, J.-H. Kim, R.J. Linhardt, and J. S. Dordick, ChemBioChem, 11, 573–580, 2010.

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