Biography

Prof. Wanxi Yang

Institute of Cell & Developmental Biology, College of Life Sciences,

Zhejiang University, China


Email: wxyang@spermlab.org


Qualifications

2001-2004 Postdoctoral, Department of  Anatomy & Cell Biology, Brody School of Medicine, East Carolina University

1997 Ph.D., Department of Biology, East China Normal University

1994 M.S., Department of Biology, Hangzhou University


Publications(Selected)

  1. Zhen-Yu She and Wan-Xi Yang*. Molecular mechanisms involved in mammalian primary sex determination. Journal of Molecular Endocrinology, 2014, 53: R21–R37.
  2. Yi-Ni Ke,Wan-Xi Yang*. Primary cilium: an elaborate structure that blocks cell division? Gene, 2014, 547: 175–185.
  3. Yang Lu, Qi Wang, Da-Hui Wang, Hong Zhou, Yan-Jun Hu, Wan-Xi Yang*. Functional Analysis of KIF3A and KIF3B during Spermiogenesis of Chinese Mitten Crab Eriocheir sinensis. PLoS ONE, 2014, 9(5): e97645. doi:10.1371/journal.pone.0097645.
  4. Xiang D.-F., Zhu J.-Q., Hou C.-C., Yang W.-X.* Identification and expression pattern analysis of Piwi genes during the spermiogenesis of Portunus trituberculatus. Gene, 2014, 534(2): 240-8.
  5. Hou C.-C., Yang W.-X.* Acroframosome-dependent KIFC1 facilitates acrosome formation during spermatogenesis in the caridean shrimp Exopalaemon modestus. PLoS One, 2013, 8(9): e76065.
  6. Hou C.-C., Yang W.-X.* Characterization and expression pattern of p53 during spermatogenesis in the Chinese mitten crab Eriocheir sinensis. Mol Biol Rep, 2013, 40(2): 1043-51.
  7. Jiang T., Hou C.-C., She Z.-Y., Yang W.-X.* The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol Biol Rep, 2013, 40(3):2187-94.
  8. Hou C.-C., Yang W.-X.* New insights to the ubiquitin-proteasome pathway (UPP) mechanism during spermatogenesis. Mol Biol Rep, 2013, 40(4): 3213-30.
  9. Xiang D.-F., Zhu J.-Q., Jin S., Hu Y.-J., Tan F.-Q., Yang W.-X.* Expression and function analysis of metallothionein in the testis of Portunus trituberculatus exposed to cadmium. Aquat Toxicol, 2013, 140-141: 1-10.
  10. Mao H.-T., Yang W.-X.* Modes of acrosin functioning during fertilization. Gene, 2013, 526(2):75-9.
  11. Hu Y.-J., Wang Y.-D., Tan F.-Q., Yang W.-X.* Regulation of paracellular permeability: factors and mechanisms. Mol Biol Rep, 2013, 40(11):6123-42.
  12. Tan F.-Q., Ma X.-X., Zhu J.-Q., Yang W.-X.* The expression pattern of the C-terminal kinesin gene kifc1 during the spermatogenesis of Sepiella maindroni. Gene. 2013, 532(1):53-62.
  13. Xu X.-R., Zhu J.-Q., Ye T., Wang C.-L., Zhu Y.-F., Dahms H.-U., Jin F., Yang W.-X.* Improvement of single-cell gel electrophoresis (SCGE) alkaline comet assay. Aquat Biol, 2013, 18: 293–295.
  14. Mao H., Wang D.-H., Yang W.-X. * The involvement of metallothionein in the development of aquatic invertebrate. Aquatic Toxicology, 2012, 110–111: 208–213.
  15. Wang Y.-T., Mao H., Hou C.-C., Sun X., Wang D.-H., Zhou H., Yang W.-X. * Characterization and expression pattern of KIFC1-like kinesin gene in the testis of the Macrobrachium nipponense with discussion of its relationship with structure lamellar complex (LCx) and acroframosome (AFS). Mol Biol Rep, 2012, 39: 7591-7598.
  16. Ma X.-X., Zhu J.-Q., Zhou H., Yang W.-X. * The formation of zona radiata in Pseudosciaena crocea revealed by light and transmission electron microscopy. Micron, 2012, 43: 435-444.
  17. Fan Y.-S., Hu Y.-J., Yang W.-X.* TGF-b superfamily: how does it regulate testis development. Mol Biol Rep, 2012, 39: 4727-4741.
  18. Sun X., Kovacs T., Hu Y.-J., Yang W.-X.*. The role of actin and myosin during spermatogenesis. Mol Biol Rep, 2011, 38:3993–4001.
  19. Sun X., He Y., Hou L., Yang W.-X.*. Myosin Va participates in acrosomal formation and nuclear morphogenesis during spermatogenesis of Chinese mitten crab Eriocheir sinensis. PLoS One, 2010, 5(9): e12738.
  20. Wang W., Zhu J.-Q., Yu H.-M., Tan F.-Q., Yang W.-X.* KIFC1-Like Motor Protein Associates with the Cephalopod Manchette and Participates in Sperm Nuclear Morphogenesis in Octopus tankahkeei. PLoS One, 2010, 5(12): e1561.
  21. Wang W., Dang R., Zhu J.-Q., Yang W.-X.*. Identification and dynamic transcription of KIF3A homologue gene in spermiogenesis of Octopus tankahkeei. Comparative Biochemistry and Physiology, Part A,  2010, 157: 237–245.
  22. Wang D.-H., Yang W.-X.* Molecular cloning and characterization of KIFC1-like kinesin gene (es-KIFC1) in the testis of the Chinese mitten crab Eriocheir sinensis. Comparative Biochemistry and Physiology, Part A , 2010, 157: 123–131.
  23. Wang W., Zhu J.-Q., Yang W.-X.*. Molecular cloning and characterization of KIFC1-like kinesin gene (ot-kifc1) from Octopus tankahkeei. Comparative Biochemistry and Physiology, Part B, 2010, 156(3): 174-182.
  24. Zhang T.-T., Jiang Y.-Q., Zhou H., Yang W.-X.* Ultrastructural observation on genesis and morphology of cortical granules in Macrobrachium nipponense (Crustacea, Caridea). Micron, 2010, 41(1): 59-64.
  25. Ying X.-P., Sun X., Wu H.-X., Dahms H.-U., Chullasorne S., Zhang Y.-P., Huang Y.-J., Yang W.-X. The fine structure of coelomocytes in the sipunculid Phascolosoma esculenta. Micron, 2010, 41: 71–78.
  26. Li Z., Zhu J-Q, Yang, W.-X.* Acrosome reaction in Octopus tankahkeei induced by calcium ionophore A23187 and a possible role of the acrosomal screw. Micron, 2010, 41 : 39-46.
  27. Li Z., Pan C.-Y., Zheng B.-H., Xiang L. and Yang W.-X.*. Immunocytochemical studies on the acroframosome during spermiogenesis of the caridean shrimp Macrobrachium nipponense (Crustacea, Natantia). Invertebrate Reproduction and Development, 2010, 54(3): 121–131.
  28. Zhao T.-F., Zhao J.-P., Yang W.-X.*. 2010. Association of the fatty acid-binding protein 2 gene Ala54Thr polymorphism with insulin resistance and blood glucose: a meta-analysis in 13451 subjects. Diabetes Metab Res Rev 2010; 26: 357–364. DOI: 10.1002/dmrr.1085.
  29. Yu, K.-M., Hou, L., Zhu, J.-Q., Ying, X.-P., Yang, W.-X. *. KIFC1 participates in acrosomal biogenesis, with discussion of its importance for the perforatorium in the Chinese mitten crab Eriocheir sinensis. Cell Tissue Res, 2009, 337:113–123.
  30. Lu Q., Zhang, J., Allison R., Gay H., Yang, W.-X., Bhowmick, N.A., Frelix, G., Shappell, S. and Chen, Y.-H.. Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection. The Prostate, 2009, 69: 411-418. (IF: 3.069)
  31. Xu W. M, Shi Q. X., Chen W. Y., Zhou C. X., Ni Y, Rowlands D. K., Liu G. Y., Zhu H., Ma Z. G., Wang X. F., Chen Z. H., S. Zhou C., Dong H. S., Zhang X. H., Chung Y. W., Yuan Y. Y., Yang, W. X. and Chan H. C.. Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2007, 104(23): 9816–9821.
  32. Yang W.-X., Jefferson H. and Sperry AO. The Molecular motor KIFC1 associates with a complex containing nucleoporin NUP62 that is regulated during development and by the small GTPase RAN. Biology of Reproduction. 2006, 74: 684-690. DOI: 10.1095/biolreprod.105.049312.
  33. Zhu, J.-Q., Yang, W.-X.*., You, Z.-J.and Jiao, H.-F.. The Ultrastructure of the spermatozoon of Octopus tankahkeei. Journal of Shellfish Research, 2005, 24 (4): 1203-1207.
  34. Yang W.-X. and Sperry A.O. C-Terminal Kinesin Motor KIFC1 Participates in Acrosome Biogenesis and Vesicle Transport. Biol. Reprod. 2003, 69(5): 1719-1729.
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