Prof. Wanxi Yang
Institute of Cell & Developmental Biology, College of Life Sciences,
Zhejiang University, China
Email: wxyang@spermlab.org
Qualifications
2001-2004 Postdoctoral, Department of Anatomy & Cell Biology, Brody
School of Medicine, East Carolina University
1997 Ph.D., Department of Biology, East China Normal University
1994 M.S., Department of Biology, Hangzhou University
Publications(Selected)
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Zhen-Yu She and Wan-Xi Yang*.
Molecular mechanisms involved in mammalian primary sex determination. Journal
of Molecular Endocrinology, 2014, 53: R21–R37.
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Yi-Ni Ke,Wan-Xi Yang*. Primary cilium: an elaborate structure that
blocks cell division? Gene, 2014, 547: 175–185.
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Yang Lu, Qi Wang, Da-Hui Wang, Hong Zhou, Yan-Jun Hu, Wan-Xi Yang*.
Functional Analysis of KIF3A and KIF3B during Spermiogenesis of Chinese Mitten
Crab Eriocheir sinensis. PLoS ONE, 2014, 9(5): e97645. doi:10.1371/journal.pone.0097645.
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Xiang D.-F., Zhu J.-Q., Hou C.-C., Yang W.-X.* Identification and
expression pattern analysis of Piwi genes during the spermiogenesis of Portunus
trituberculatus. Gene, 2014, 534(2): 240-8.
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Hou C.-C., Yang W.-X.* Acroframosome-dependent KIFC1 facilitates
acrosome formation during spermatogenesis in the caridean shrimp Exopalaemon
modestus. PLoS One, 2013, 8(9): e76065.
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Hou C.-C., Yang W.-X.* Characterization and expression pattern of
p53 during spermatogenesis in the Chinese mitten crab Eriocheir sinensis. Mol
Biol Rep, 2013, 40(2): 1043-51.
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Jiang T., Hou C.-C., She Z.-Y., Yang W.-X.* The SOX gene family:
function and regulation in testis determination and male fertility maintenance.
Mol Biol Rep, 2013, 40(3):2187-94.
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Hou C.-C., Yang W.-X.* New insights to the ubiquitin-proteasome
pathway (UPP) mechanism during spermatogenesis. Mol Biol Rep, 2013,
40(4): 3213-30.
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Xiang D.-F., Zhu J.-Q., Jin S., Hu Y.-J., Tan F.-Q., Yang W.-X.*
Expression and function analysis of metallothionein in the testis of Portunus
trituberculatus exposed to cadmium. Aquat Toxicol, 2013, 140-141: 1-10.
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Mao H.-T., Yang W.-X.* Modes of acrosin functioning during
fertilization. Gene, 2013, 526(2):75-9.
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Hu Y.-J., Wang Y.-D., Tan F.-Q., Yang W.-X.* Regulation of paracellular
permeability: factors and mechanisms. Mol Biol Rep, 2013, 40(11):6123-42.
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Tan F.-Q., Ma X.-X., Zhu J.-Q., Yang W.-X.* The expression pattern
of the C-terminal kinesin gene kifc1 during the spermatogenesis of Sepiella
maindroni. Gene. 2013, 532(1):53-62.
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Xu X.-R., Zhu J.-Q., Ye T., Wang C.-L., Zhu Y.-F., Dahms H.-U., Jin
F., Yang W.-X.* Improvement of single-cell gel electrophoresis (SCGE) alkaline
comet assay. Aquat Biol, 2013, 18: 293–295.
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Mao H., Wang D.-H., Yang W.-X. * The involvement of metallothionein
in the development of aquatic invertebrate. Aquatic Toxicology, 2012, 110–111:
208–213.
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Wang Y.-T., Mao H., Hou C.-C., Sun X., Wang D.-H., Zhou H., Yang
W.-X. * Characterization and expression pattern of KIFC1-like kinesin gene in
the testis of the Macrobrachium nipponense with discussion of its relationship
with structure lamellar complex (LCx) and acroframosome (AFS). Mol Biol Rep,
2012, 39: 7591-7598.
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Ma X.-X., Zhu J.-Q., Zhou H., Yang W.-X. * The formation of zona
radiata in Pseudosciaena crocea revealed by light and transmission electron
microscopy. Micron, 2012, 43: 435-444.
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Fan Y.-S., Hu Y.-J., Yang W.-X.* TGF-b superfamily: how does it
regulate testis development. Mol Biol Rep, 2012, 39: 4727-4741.
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Sun X., Kovacs T., Hu Y.-J., Yang W.-X.*. The role of actin and
myosin during spermatogenesis. Mol Biol Rep, 2011, 38:3993–4001.
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Sun X., He Y., Hou L., Yang W.-X.*. Myosin Va participates in
acrosomal formation and nuclear morphogenesis during spermatogenesis of Chinese
mitten crab Eriocheir sinensis. PLoS One, 2010, 5(9): e12738.
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Wang W., Zhu J.-Q., Yu H.-M., Tan F.-Q., Yang W.-X.* KIFC1-Like
Motor Protein Associates with the Cephalopod Manchette and Participates in
Sperm Nuclear Morphogenesis in Octopus tankahkeei. PLoS One, 2010, 5(12):
e1561.
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Wang W., Dang R., Zhu J.-Q., Yang W.-X.*. Identification and dynamic
transcription of KIF3A homologue gene in spermiogenesis of Octopus tankahkeei.
Comparative Biochemistry and Physiology, Part A, 2010, 157: 237–245.
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Wang D.-H., Yang W.-X.* Molecular cloning and characterization of
KIFC1-like kinesin gene (es-KIFC1) in the testis of the Chinese mitten crab
Eriocheir sinensis. Comparative Biochemistry and Physiology, Part A , 2010,
157: 123–131.
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Wang W., Zhu J.-Q., Yang W.-X.*. Molecular cloning and
characterization of KIFC1-like kinesin gene (ot-kifc1) from Octopus tankahkeei.
Comparative Biochemistry and Physiology, Part B, 2010, 156(3): 174-182.
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Zhang T.-T., Jiang Y.-Q., Zhou H., Yang W.-X.* Ultrastructural
observation on genesis and morphology of cortical granules in Macrobrachium
nipponense (Crustacea, Caridea). Micron, 2010, 41(1): 59-64.
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Ying X.-P., Sun X., Wu H.-X., Dahms H.-U., Chullasorne S., Zhang
Y.-P., Huang Y.-J., Yang W.-X. The fine structure of coelomocytes in the
sipunculid Phascolosoma esculenta. Micron, 2010, 41: 71–78.
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Li Z., Zhu J-Q, Yang, W.-X.* Acrosome reaction in Octopus
tankahkeei induced by calcium ionophore A23187 and a possible role of the
acrosomal screw. Micron, 2010, 41 : 39-46.
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Li Z., Pan C.-Y., Zheng B.-H., Xiang L. and Yang W.-X.*.
Immunocytochemical studies on the acroframosome during spermiogenesis of the
caridean shrimp Macrobrachium nipponense (Crustacea, Natantia). Invertebrate
Reproduction and Development, 2010, 54(3): 121–131.
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Zhao T.-F., Zhao J.-P., Yang W.-X.*. 2010. Association of the fatty
acid-binding protein 2 gene Ala54Thr polymorphism with insulin resistance and
blood glucose: a meta-analysis in 13451 subjects. Diabetes Metab Res Rev 2010;
26: 357–364. DOI: 10.1002/dmrr.1085.
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Yu, K.-M., Hou, L., Zhu, J.-Q., Ying, X.-P., Yang, W.-X. *. KIFC1
participates in acrosomal biogenesis, with discussion of its importance for the
perforatorium in the Chinese mitten crab Eriocheir sinensis. Cell Tissue Res,
2009, 337:113–123.
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Lu Q., Zhang, J., Allison R., Gay H., Yang, W.-X., Bhowmick, N.A.,
Frelix, G., Shappell, S. and Chen, Y.-H.. Identification of Extracellular
d-Catenin Accumulation for Prostate Cancer Detection. The Prostate, 2009, 69:
411-418. (IF: 3.069)
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Xu W. M, Shi Q. X., Chen W. Y., Zhou C. X., Ni Y, Rowlands D. K.,
Liu G. Y., Zhu H., Ma Z. G., Wang X. F., Chen Z. H., S. Zhou C., Dong H. S.,
Zhang X. H., Chung Y. W., Yuan Y. Y., Yang, W. X. and Chan H. C.. Cystic
fibrosis transmembrane conductance regulator is vital to sperm fertilizing
capacity and male fertility. Proceedings of the National Academy of Sciences of
the United States of America (PNAS), 2007, 104(23): 9816–9821.
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Yang W.-X., Jefferson H. and Sperry AO. The Molecular motor KIFC1
associates with a complex containing nucleoporin NUP62 that is regulated during
development and by the small GTPase RAN. Biology of Reproduction. 2006, 74:
684-690. DOI: 10.1095/biolreprod.105.049312.
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Zhu, J.-Q., Yang, W.-X.*., You, Z.-J.and Jiao, H.-F.. The
Ultrastructure of the spermatozoon of Octopus tankahkeei. Journal of Shellfish
Research, 2005, 24 (4): 1203-1207.
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Yang W.-X. and Sperry A.O. C-Terminal Kinesin Motor KIFC1
Participates in Acrosome Biogenesis and Vesicle Transport. Biol. Reprod. 2003,
69(5): 1719-1729.