Dr. Madhu Dhar
Department of
Large Animal Clinical Sciences
University of
Tennessee, USA
E-mail: dliu@psu.edu
Qualifications
Ph.D., Chemistry,
University of Poona, India
M.S.,
Biochemistry, University of Poona, India
B.S., Chemistry,
University of Poona, India
Publications (Selected)
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Madhu S Dhar,
Nancy Neilsen, Kate Beatty, Henry Adair, and Dennis Geiser. Equine peripheral
blood-derived mesenchymal stem cells: isolation, identification, trilineage
differentiation and effect of hyperbaric oxygen treatment.Equine Vet
Journal (2011) In press.
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Sarah Elizabeth Hurst,
Steven Minkin, John Biggerstaff, and Madhu Dhar. Transient Silencing
of a Type IV P-type ATPase, Atp10c, Results in Decreased Glucose
Uptake in C2C12 Myotubes. Journal of Nutrition and Metabolism (2011) In
press.
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Sarah Elizabeth Hurst,
Steven Minkin, John Biggerstaff, and Madhu Dhar Characterization of
ATP10C and multiple signaling pathway proteins in C2C12 cells using immunoblot
assays and immunofluorescence microscopy FASEB J25:530.7 (2011).
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Madhu S Dhar,
Nancy Neilsen, Kate Beatty, Henry Adair, and Dennis Geiser. Equine
peripheral blood-derived mesenchymal stem Cells: isolation, identification,
adipocyte differentiation and effect of hyperbaric oxygen treatment.FASEB J 25:679.4 (2011).
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Roshwalb, S.,
Gormann, S., Hurst, S., Agarwal, S.A., Odoi, A. Bartges, J., Sommardahl, C. and Dhar
M.S. Molecular identification and characterization of canine ATP10C, a
type 4 ATPase involved in body weight and insulin sensitivity. The
Veterinary Journal (2010) Oct 5. [Epub ahead of print]
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Peretich, A.L.,
Cekanova, M., Hurst, S., Baek, S.J. and Dhar, M.S. PPARgamma agonists
PPARgagonists down-regulate the expression of Atp10c mRNA
during adipogenesis. The Open Obesity Journal 1, 41-48
(2009).
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Sarah Elizabeth
Hurst, Amanda Peretich, Steven Minkin, John Dunlap, John Biggerstaff, and Madhu
Dhar. In vitro silencing of a putative phospholipid translocase results in an
increase in glucose uptake in 3T3 L1 adipocytes.FASEB J. 23: 505.2
(2009).
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Peretich, A.L.,
Abbott, L.L., Andrews, F.M. and Dhar M.S. Age-dependent regulation of
sodiumpotassium ATPase and sodium-hydrogen exchanger mRNAs in equine
nonglandular mucosa. American Journal of Veterinary Research
70(9), 1124-1128(2009).
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Michael Hance, Madhu
Dhar and H K Plummer Tobacco carcinogens stimulate different signaling
pathways in breast cancer. Breast Cancer: Basic and Clinical Research
1, 25-34 (2008).
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Abbott, L.L.,
Peretich, A.L., Andrews, F.M. and Dhar M.S. Role of sodium-potassium
ATPase and sodium-hydrogen exchanger in mRNA in equine gastric ulcer syndrome. Proceedings
of the 9thInternational Equine Colic Research Symposium June 15, p28
(2008).
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Peretich, A.,
Pineda, A'Drian, Neilsen, N., Graham, T. and Dhar, M., Regulation of Atp10c mRNA
expression in mouse 3T3-L1 adipocytes. FASEB J., 21: p. 523.8 (2007).
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M.S. Dhar and
H.K. Plummer 3rd Protein expression of G-protein inwardly rectifying potassium
channels (GIRK) in breast cancer cells. BMC Physiol. 6(8) (2006).
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N. Frank, M.Dhar, S.
Elliott and Joshua S. Yuan Effects of long-term levothyroxine administration on
adipose and skeletal muscle tissue glucose transporter gene expression in
mares. Journal of VeterinaryInternal Medicine 20:743 (2006).
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Madhu S. Dhar,
Joshua S. Yuan, Sarah B. Elliott and Carla Sommardahl A type IV P-type ATPase
affects insulin-mediated glucose uptake in adipose tissue and skeletal muscle
in mice. Journal ofNutritional Biochemistry 17(12), 811-20 (2006) Epub
2006 Feb 3.
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F. Ding , Y.
Prints , M. S. Dhar, D.K. Johnson, C. Garnacho-Montero, R.D. Nicholls and
U. Francke Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in
Prader-Willi syndrome mouse models.Mammalian Genome. 16(6), 424-31 (2005).
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H.K. Plummer 3rd, M.S.
Dhar, M. Cekanova and H.M. Schuller Expression of G-protein inwardly rectifying
potassium channels (GIRKs) in lung cancer cell lines. BMC Cancer.
18(5), 104 (2005).
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Howard Plummer
3rd, Madhu Dhar and Hildergarde Schuller Expression of the alpha 7
nicotinic acetylcholine receptor in human lung cells. Respiratory
Research 6, 29-38 (2005).
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Madhu Dhar, Loren
Hauser, Robert Nicholls and Dabney Johnson Physical mapping of the pink-eyed
dilution complex in mouse chromosome 7 shows that Atp10c is
the only transcript between Gabrb3 andUbe3a. DNA
Sequence 15(4), 306-309 (2004).
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Y. Wang, Brynn
Voy Jones, Sumitra Urs, Suyeon Kim, Morvarid Soltani-Bejnood, Neal Quigley,
Y.R. Heo, Melissa Standridge, Brett Andersen, Madhu Dhar, Rashika Joshi,
Patrick Wortman, J.W. Taylor, J. Chun, M. Leuze, Kate Claycombe, Alan Saxton
and Naima Moustaid-Moussa The human fatty acid synthase gene and de novo
lipogenesis are coordinately regulated in human adipose tissue. Journal
ofNutrition 134(5), 1032-8, (2004).
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Madhu Dhar, Carla
Sommardahl, Sarah Nelson, Tanisa Kirkland, Larry Castellani, Robert Donnell and
Dabney Johnson Mice heterozygous for Atp10c, a putative amphipath,
represent a novel mouse model of obesity and type 2 diabetes.Journal of
Nutrition 134, 799-805 (2004).
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R.D. Nicholls, M.
Stefan, H. Ji, Y. Qi, R.S. Frayo, R.H. Wharton, M.S. Dhar, D.E. Cummings,
M.I. Friedman and R.S. Ahima Mouse models for Prader-Willi and Angelman
syndromes offer insights into novel obesity mechanisms. In: Progress in
Obesity Research, 9, Medeiros-Neto, G., Halpern, A. and Bouchard,
C. eds. John Libbey Eurotext Ltd. 313-319 (2003).
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Madhu Dhar, Loren
Hauser, and Dabney Johnson An aminophospholipid translocase associated with
body fat and type 2 diabetes phenotypes. Obesity Research 10(7), 695-702, (2002).
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Madhu S. Dhar Ferritin:
A novel human ferritin heavy chain mRNA is predominantly expressed in the adult
brain. In: Nutrition and Gene Expression, Berdanier, C.D. and Moussa,
N.M. eds. CRC Press, Boca Raton, Florida. (Chapter 18, 449-459) (2001).
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Jennifer L.
Aponte, Gary A. Sega, Loren Hauser, Madhu S. Dhar, Catherine M. Withrow,
Donald A. Carpenter, Eugene M. Rinchik, Cymbeline T. Culiat, and Dabney Johnson
Point Mutations in the Murine Fumarylacetoacetate gene: Animal Models for the
Human Genetic Disorder Hereditary Tyrosinemia Type I. PNAS, USA, 98(2),
641-645, (2001).
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Madhu Dhar, Lisa
Webb, Laurel Smith, Loren Hauser, Dabney Johnson and David West A Novel ATPase
on Mouse Chromosome 7 is a candidate gene for increased Body Fat. Physiological
Genomics 4, 93-100, (2000).
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Paulus, M. J., S.
S. Gleason, H. Sari-Sarraf, D. K. Johnson, C. J. Foltz, D. W. Austin, M. E.
Easterly, E. J. chaud, M. S. Dhar, P. R. Hunsicker, J. W. Wall, M.
Schell.. High-resolution X-ray CT screening f mutant mouse models.Proc. SPIE
3921:270-279, (2000).
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M. Shuster, M.S.
Dhar, A.L. Olins, D.E. Olins, C.Y. Howell, S.M. Gollin and J.R. Chaillet
Parental alleles of an imprinted mouse transgene replicate synchronously. Dev.
Genet. 23 (4), 275-284, (1998).
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M.E. Percy, S.
Wong, S. Bauer, N. Liaghati, M.D. Perry, V.M. Chauthaiwale, M. Dhar and
J.G. Joshi Iron Metabolism and human ferritin heavy chain cDNA from adult brain
with an elongated untranslated region : new findings and insights. Analyst
123, 41, (1998).
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M.S.Dhar and
D.K.Johnson A microsatellite map of the pink-eyed dilution (p) deletion
complex in Mouse Chromosome 7. Mammalian Genome 8(2), 143-145, (1997).
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M.E. Percy, S.J.
Bauer, S. Rainey, D.R.C. McLachlan, M. Dhar and J.G. Joshi
Localization of a new ferritin heavy chain sequence present in human brain mRNA
to chromosome 11. Genome 38, 450-457,(1995).
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L.J. Hauser, M.S.
Dhar and D.E. Olins Dictyostelium discoideum contains a
single-subtype of histone H1 present as a single-copy gene. Gene 154,
119-122, (1995).
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M.S. Dhar and
J.G. Joshi Detection and quantitation of the novel ferritin heavy chain message
in human tissues. Biofactors 4, 147-149, (1994).
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J.G. Joshi, M.S.
Dhar, M. Clauberg and V. Chauthaiwale Iron and aluminum homeostasis in neural
disorders. Environmental Health Perspectives Supplements 102,
Supplement 4, (1994).
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A.L. Olins, L.H.
Cacheiro, A.L. Herrmann, M.S. Dhar and D.E. Olins Inaccessibility of
the Euplotes telomere binding protein. Chromosoma 102,
700-711, (1994).
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M. S. Dhar and
J. G. Joshi Differential processing of the ferritin heavy chain mRNA in human
liver and adult human brain. J. Neurochemistry 61, 2140-2146, (1993).
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K.D. Swanson, M.S.
Dhar and J.G. Joshi The human and bovine 14-3-3n protein mRNAs are highly
conserved in both their translated and untranslated regions. Biochem.
Biophys. Acta 1216, 145-148,(1993).
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J. C. Chen, P. A.
Hardy, W. Kucharczyk, M. Clauberg, J. G. Joshi, A. Vourlas, M. S. Dhar and
R. M. Henkelman. MR of human postmortem brain tissue: Correlative study between
T2 and assays of iron and ferritin in Parkinson and Huntington disease. American
J. of Neuroradiology, 14, 275-281, (1993).
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M. Dhar, V.
Chauthaiwale, and J. G. Joshi Sequence of a cDNA encoding the ferritin H-chain
from an 11-week human fetal brain. Gene, 126 (2), 275-278, (1993).
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J. G. Joshi, M.
Clauberg and M. S. Dhar Role of Aluminum and Iron in brain disorders. In:
Advances in Behavioral Biology, 40, Treatment of Dementias, Ed. Edwin M. Meyer,
J. W. Simkpins, J. Yamamoto and F. T. Crews, 387-396, Plenum press, NY, (1992).
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M. S. Dhar, V. V.
Pethe, V. S. Gupta and P. K. Ranjekar Predominance and tissue specificity of
adenine methylation in rice. Theor. Appl. Genet., 80, 402-408, (1990).
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V.S. Gupta, M.S.
Dhar, B.G. Patil, G.S. Narvekar, S.R. Rawat and P.K. Ranjekar Molecular cloning
and restriction enzyme analysis of a long repetitive DNA sequence in rice. J.
Bioscience (India) 15,145-149, (1990).
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M. S. Dhar, M. M.
Dabak, V. S. Gupta and P. K. Ranjekar Organization and properties of repeated
DNA sequences in rice genome. Plant Science 66 (1), 43-52, (1988).
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S. A. Ranade, M.
D. Lagu, S. M. Patankar, M. M. Dabak, M. S. Dhar, V. S. Gupta and P. K.
Ranjekar Identification of a dispersed Mbo I repeat
family in five higher plant genomes. Bioscience Reports(U.K.), 8 (5),
435-442, (1988).
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M.M. Dabak, S.A.
Ranade, M.S. Dhar, V.S. Gupta and P.K. Ranjekar Molecular characterization
of Pigeonpea genome. Indian Journal of Biochemistry and
Biophysics 25 (3), 230-236, (1988).