Dr. Sydney Chi-Wai Tang
University of Hong Kong, China
Email: scwtang@hku.hk
Qualifications
2005 Ph.D., the University of Hong Kong
2001 M.D., the University of Hong Kong
1991 M.B., B.S., the University of Hong Kong
Publications (Selected)
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Tang S, Zhou W, Sheerin NS, Vaughan RW, Sacks SH: Contribution of renal secreted complement C3 to the circulating pool in humans.J Immunol162: 4336-4341, 1999.
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Tang S, Sheerin NS, Zhou W, Brown Z, Sacks SH: Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells. J Am Soc Nephrol10: 69-76, 1999.
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Tang S, Leung JCK, Lam CWK, Lai FM, Chan TM, Lai KN: In vitro studies of aquaporins 1 and 3 expression in cultured human proximal tubular cells: upregulation by transferrin but not albumin. Am J Kidney Dis38: 317-330, 2001.
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Tang S, Lai KN, Chan TM, Lan HY, Ho SK, Sacks SH: Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells. Am J Kidney Dis37: 94-103, 2001.
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Tang S, Leung JC, Tsang AW, Lan HY, Chan TM, Lai KN: Transferrin up-regulates chemokine synthesis by human proximal tubular epithelial cells: Implication on mechanism of tubuloglomerular communication in glomerulopathic proteinuria. Kidney Int61: 1655-1665, 2002.
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Tang S, Ho SK, Moniri K, Lai KN, Chan TM: Efficacy of famciclovir in the treatment of lamivudine resistance related to an atypical hepatitis B virus mutant.Transplantation 73: 148-151, 2002 Tang S, Leung JC, Abe K, Chan KW, Chan LY, Chan TM, Lai KN: Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest111: 515-527, 2003.
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Tang S, Cheng IK, Leung VK, Kuok UI, Tang AW, Ho YW, Lai KN, Chan TM: Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin. J Hepatol39: 875-878, 2003.
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Tang S, Leung JC, Chan LY, Lui YH, Tang CS, Kan CH, Ho YW, Lai KN: Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy. Kidney Int68: 802-812, 2005.
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Tang S, Lai FM, Lui YH, Tang CS, Kung NN, Ho YW, Chan KW, Leung JC, Lai KN: Lamivudine in hepatitis B-associated membranous nephropathy. Kidney Int68: 1750-1758, 2005.
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TangSC, Leung JC, Chan LY, Tsang AW, Lai KN: Activation of tubular epithelial cells in diabetic nephropathy and the role of the PPAR-gagonist. J Am Soc Nephrol17: 1633-1643, 2006.
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TangSC, Lam B, Ku PP, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN: Alleviation of sleep apnea in patients with chronic renal failure by nocturnal cycler-assisted peritoneal dialysis. J Am Soc Nephrol17: 2607-2616, 2006.
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Lai KN, Leung JCK, Chan LY, Guo H, Tang SC:Interaction between proximal tubular epithelial cells and infiltrating monocytes/T cellsin the proteinuric state. Kidney Int71: 526-538, 2007.
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TangSC, Leung JC, Chan LY, Eddy AA, Lai KN: Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy. Kidney Int73: 288-299, 2008.
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TangSC, Lai KN: The ubiquitin-proteasome pathway and IgA nephropathy: a novel link?Kidney Int75, 457-459, 2009.
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TangSC, Lam B, Lai AS, Pang CB, Tso WK, Khong PL, Ip MS, Lai KN: Improvement in sleep apnea during nocturnal peritoneal dialysis is associated with reduced airway congestion and better uremic clearance. Clin J Am Soc Nephrol4: 410-418, 2009.
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TangSC, Leung VT, Chan LY, Wong SH, Chu DW, Leung JC, Lai KN, Ma L, Elbein SC, Bowden DW, Hicks PJ, Comeau ME, Langefeld, Freedman BI: The acetyl-coenzyme A carboxylase beta gene (ACACB) is associated with nephropathy in Chinese patients with type 2 diabetes. Nephrol Dial Transplant: 25: 3931-3934, 2010.
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TangSC, Leung JC, Chan LY, Lan HY, Lai KN: Renoprotection by rosiglitazone in accelerated type 2 diabetic nephropathy: role of STAT1 inhibition and nephrin restoration. Am J Nephrol32: 145-155, 2010.
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TangSC, Lam B, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN: Sleep apnea as a novel risk predictor for cardiovascular morbidity and death in peritoneal dialysis patients. Kidney Int77: 1031-1038, 2010.
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TangSC, Tang AW, Wong SH, Ho YW, and Lai KN: Long-term study of mycophenolate mofetil in IgA nephropathy. Kidney Int77: 543-549, 2010.
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TangSC, Chan LY, Leung JC, Cheng AS, Lan HY, Lai KN: Synergistic renoprotective effects of B2-kinin receptor blocker and PPAR-gagonist in uninephrectomized db/db mice. Lab Invest.