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Dr. Matthias Klugmann

University of New South Wales, Australia

Email: m.klugmann@unsw.edu.au


1999 Ph.D., University of Heidelberg

1995 M.Sc., University of Heidelberg

Publications (Selected)

1. Haider A., Woodward N.C., Lominac K.D., Sacramento A.D., Klugmann M., Bell R.L., Szumlinski K.K. (in press). Homer2 within the nucleus accumbens core bi-directionally regulates alcohol intake by both P and Wistar rats.

2. Froud K.E., Wong A.C., Cederholm J.M., Klugmann M., Sandow S.L., Julien J.P., Ryan A.F., Housley G.D. (2015). Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. Nat. Commun. 6:7115.

3. Guggenhuber S., Alpar A., Chen R., Schmitz N., Wickert M., Mattheus T., Harasta A.E., Purrio M., Kaiser N., Elphick M.R., Monory K., Kilb W., Luhmann HJ., Harkany T., Lutz B., Klugmann M. (2015). Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus. Brain Struct Funct. Epub ahead of print March 15.

4. Harasta A.E., Power J.M., von Jonquieres G., Karl T., Drucker D.J., Housley G.D., Schneider M., Klugmann M. (2015). Septal glucagon-like peptide 1 receptor expression determines suppression of cocaine-induced behaviour. Neuropsychopharmacology. 40:1969-78.

5. Rowlands B., Lau C., Ryall J., Thomas D., Klugmann M., Beart P., Rae C. (2015). SIRT1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism while SRT1720 increases oxidative metabolism. J. Neurosci. Res. 93:1147-56.

6. Gould A.T., Sacramento A.D., Wroten M.G., Miller B.W., von Jonquieres G., Klugmann M., Ben-Sahar O., Szumlinski K.K. (2015). Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression: implications for relapse. Addict. Biol. 20(1):148-157.

7. von Jonquieres G., Froud K.E., Klugmann C.B., Wong A.C.Y., Housley G.D., Klugmann M. (2014). Loss of central auditory processing in a mouse model of Canavan disease. PLoS ONE. 9(5):e97374.

8. Lin E.-J.D., Symes C.W., Townsend-Nicholson A., Klugmann M., Klugmann C.B., Lehnert K., Fong, D. Young, D. During M.J. (2014). An immunological approach to increase the brain’s resilience to insults. ISRN Neuroscience 2014:103213. doi:10.1155/2014/103213.

9. Pinyon J.L., Tadros S.F., Froud K.E., Wong A.C.Y., Tompson I.T., Crawford E.N., Ko M., Morris R., Klugmann M., Housley G.D. (2014). Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear. Science Translational Medicine 6(233):233ra54. doi:10.1126/scitranslmed.3008177.

10. Vogt-Eisele A., Krüger C., Duning K., Weber D., Spoelgen R., Pitzer C., Plaas C., Eisenhardt G., Meyer A., Vogt G., Krieger M., Handwerker E., Wennmann D.O., Weide T., Skryabin B.V., Klugmann M., Pavenstädt H., Huentelmann M.J., Kremerskothen J., Schneider A. (2014). KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ. J. Neurochem. 128(5):686-700.

11. Cozzoli D.K., Courson J., Wroten M.G., Greentree D.I., Lum E.N., Campbell R.R., Thompson A.B., Maliniak D., Worley P.F., von Jonquieres G., Klugmann M., Finn D.A., Szumlinski K.K. (2014). Binge alcohol drinking by mice requires intact Group1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala. Neuropsychopharmacology.39(2):435-44.

12. Frühbeis C., Fröhlich D., Kuo W.P., Amphornrat J., Thilemann S., Saab A.S., Kirchhoff F., Möbius W., Goebbels S., Nave K.-A., Schneider A., Simons M., Klugmann M., Trotter J. and Krämer-Albers E.-M. (2013). Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 11:e1001604.

13. Obara I., Goulding S.P., Gould A.T., Lominac K.D, Hu J.-H., Zhang P.W., von Jonquieres G., Dehoff M., Xiao B., Seeburg P.H., Worley P.F., Klugmann M., and Szumlinski K.K. Matthias Klugmann 6 (2013). Homers at the interface between reward and pain. Front. Psychiatry. 4:39. doi:10.3389/fpsyt.2013.00039.

14. von Jonquieres G., Mersmann N., Klugmann C.B., Harasta A.E., Lutz B., Teahan O., Housley G.D., Fröhlich D., Krämer-Albers E.-M., Klugmann M. (2013). Glial promoter selectivity following AAV-delivery to the immature brain. PLoS ONE. 8(6): e65646.

15. Obara I., Goulding S.P., Hu J.H., Klugmann M., Worley P.F., Szumlinski K.K. (2013). Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain. Pain. 154:1932-45.

16. El-Kordi A., Kästner A., Grube S., Klugmann M., Werner H., Begemann M., Sperling S., Ronnenberg A., Hammerschmidt K., Hammer C., Stepniak B., Patzig J., Monastero P., Strenzke N., Fluegge G., Pawlak R., Nave K.-A., and Ehrenreich H. (2013). A single gene defect causing claustrophobia. Transl. Psych. 3:e254.

17. Ary A.W., Lominac K.D., Williams A.R., Wroten M.G., Ben-Shahar O., Klugmann M., Szumlinski K.K. (2013). Imbalances in prefrontal cortex CC-Homer1 versus –Homer2 expression promote cocaine seeking behavior. J. Neurosci. 33:8101-13.

18. Freudenberg F., Marx V., Mack V., Layer L.E., Klugmann M., Seeburg P.H., Sprengel R., Celikel T. (2013). GluA1 and its PDZ-interaction: a role in experience-dependent behavioral plasticity in the forced swim test. Neurobiol Dis. 52:160-7.

19. Krieger M., Both M., Kranig S.A., Pitzer C., Klugmann M., Vogt G., Draguhn A., Schneider A. (2012). The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions. Sci Rep. 2:697.

20. Cardinal P., Bellocchio L., Clark S., Cannich A., Klugmann M., Lutz B., Marsicano G., Cota D. (2012). Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice. Endocrinology. 153:4136-43.

21. Kim T., Wong A.C.Y., Power J., Tadros S., Klugmann M., Moorhouse A., Bertrand P., Housley G.D. (2012). Alternative splicing of the TRPC3 ion channel calmodulin - IP3 receptor binding (CIRB) domain in the hind brain enhances cation flux. J. Neurosci. 32:11414-23.

22. Cozzoli D.K., Courson J., Caruana A.L., Miller B.W., Zhang P.W., Xiao B., Hu J.-H., Klugmann M., Metten P., Worley P.F., Crabbe J.C., Szumlinski K.K. (2012). Accumbens shell metabotropic glutamate receptor 5-associated signaling regulates binge alcohol drinking: Evidence from Drinking-in-the-Dark studies. Alcohol Clin Exp Res. 36:1623-33.

23. Bernard G., Massa F., Puente N., Lourenço J., Bellocchio L., Soria-Gomez E., Matias I.,Delamarre A., Metna-Laurent M., Cannich A., Hebert-Chatelain E., Mulle C., Ortega-Gutierrez S., Martín-Fontecha M., Klugmann M., Guggenhuber S., Lutz B., Gertsch J., Chaouloff F., López-Rodríguez M.L., Grandes P., Rossignol R., Marsicano G. (2012). Mitochondrial CB1 receptors regulate neuronal energy metabolism. Nat. Neurosci. 15:558-64.

24. Nagode D.A., Tang A.-H., Karson M.A., Klugmann M., Alger B.E. (2011). Optogenetic release of ACh induces rhythmic bursts of perisomatic IPSCs in hippocampus. PLoS ONE. 6(11):e27691.

25. McClure C., Cole K., Wulff P., *Klugmann M., Murray A.J. (2011). Production and titering of recombinant adeno-associated viral vectors. J. Vis. Exp. Nov 27;(57):e3348. doi:10.3791/3348. *Corresponding author.

26. Tang A.-H., Karson M.A., Nagode D.A., McIntosh J.M., Uebele V., Renger J., Klugmann M., Milner T.A., Alger B.E. (2011). Nerve terminal nAChRs initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca2+ channels and Ca2+release from stores. J. Neurosci. 31:13546-13561.

27. Klugmann M., Goepfrich A., Friemel C.M., Schneider M. (2011). AAV-mediated overexpression of the CB1 receptor in the mPFC of adult rats alters cognitive flexibility and emotional behavior. Front. Behav. Neurosci. 5:37.

28. Mersmann, M., Tkachev, D., Jelinek, R., Möbius, W., Ruhwedel, T., Ruhle, S., Weber-Fahr, W., Sartorius, A., Klugmann, M. (in revision). An engineered model of Canavan disease for conditionaldeletion of the apsartocylase gene.

29. Klugmann, M., Klippenstein, V., Leweke, M., Spanagel, R., Schneider, M. (2011). Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. Int J Neuropsychopharmacol. Jan 7:1-13. [Epub ahead of print]

30. Guggenhuber, S., Monory, K., Lutz, B., Klugmann, M. (2010). Virus-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects from seizure-induced excitotoxicity. PLoS One. 5(12):e15707.

31. Henriques, A., Pitzer, C., Dittgen, T., Klugmann, M., Dupuis, L., Schneider, A. (2011). CNS-targeted viral delivery of G-CSF in an animal model for ALS: Improved efficacy and preservation of the neuromuscular unit Mol. Ther. 19:284-92.

32. Goulding, S.P., Obara, I., Lominac, K.D., Gould, A.T., Miller, B.W., Klugmann, M., Szumlinski, K.K.(2011). Accumbens Homer2-mediated signaling: A factor contributing to mouse strain differences in alcohol drinking? Genes, Brain and Behav. 10:111-26.

33. Rogalewski, A., Dittgen, T., Klugmann, M., Kirsch, F., Krüger, C., Pitzer, C., Schäbitz, W.-R., Schneider, A. (2010). Semaphorin 6A improves functional recovery in conjunction with motor training after cerebral ischemia. PLoS One. 5:e10737.

35. Knackstedt, L.A., Lalumiere, R., Moussawi, K., Schwendt, M., Klugmann, M., Kalivas, P.W. (2010). Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J. Neurosci. 30:7984-7992.