Dr. Alexander Y. Tsygankov
Temple University, USA
Email: tsygan@temple.edu
Qualifications
1988 Ph.D.,
Bach Institute of Biochemistry, Russia
1982 M.Sc.,
Moscow University, Russia
1980 B.Sc.,
Moscow University, Russia
Publications (Selected)
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Tsygankov, A.Y., Spana, C., Rowley, B.R.,
Penhallow, R.C., Burkhardt, A.L., Bolen, J.B. Activation-dependent tyrosine
phosphorylation of Fyn-associated proteins in T lymphocytes. J. Biol. Chem.
269:7792-7800, 1994. PMID: 8126006
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Feshchenko, E.A., Langdon, W.Y., Tsygankov, A.Y.
Fyn, Yes and Syk phosphorylation sites in c‑Cbl map to the same tyrosine
residues that become phosphorylated in activated T cells. J. Biol. Chem.
273:8323-8331, 1998. PMID: 9525940
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Feshchenko, E.A., Shore, S.K., Tsygankov, A.Y.
Tyrosine phosphorylation of c‑Cbl facilitates adhesion and spreading of NIH 3T3
cells while suppressing their transformation by v‑Abl. Oncogene 18:3703-3715,
1999. PMID: 10391678
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HIV Henderson, E.E., Tsygankov, A.Y., Merlo,
J.J., Romano, G., Guan, M. Altered replication of human immunodeficiency virus
type 1 (HIV-1) in T cell lines retrovirally transduced to express Herpesvirus
saimiri proteins StpC and/or Tip. Virology. 264:125-33,1999. PMID: 10544137
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Levkowitz, G., Waterman, H., Ettenberg, S.A.,
Tsygankov, A.Y., Alroy, I., Lavi, S., Iwai, K., Reiss, Y., Ciechanover, A.,
Lipkowitz, S., Yarden, Y. Ubiquitin conjugation to EGF-receptors is mediated by
Cbl proto-oncogenic proteins and tyrosine phosphorylation. Molecular Cell
4:1029-1040, 1999. PMID: 10635327
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Teckchandani, A.M., Feshchenko, E.A., Tsygankov,
A.Y. c‑Cbl facilitates fibronectin matrix production by v‑Abl-transformed NIH
3T3 cells via activation of small GTPases. Oncogene 20:1739-1755, 2001. PMID:
11313921
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HIV Hasham, M.G., Tsygankov, A.Y. Tip, an
Lck-interacting protein of Herpesvirus saimiri, causes Fas- and Lck-dependent
apoptosis of T lymphocytes. Virology. 320:313-329, 2004. PMID: 1501655
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Feshchenko, E.A., Swaminathan, G., Teckchandani,
A.M., Agrawal, R., Smirnova, E.V., Zhang, X., Annan, R.S., Carr, S.A.,
Tsygankov, A.Y. TULA: An SH3- and UBA-containing protein that binds to c-Cbl
and ubiquitin. Oncogene, 23:4690-4706, 2004. PMID: 15107835
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Sorokina, E.M., Merlo, J.J. Jr., Tsygankov, A.Y.
Molecular mechanisms of the effect of Herpesvirus saimiri protein StpC on the
signaling pathway leading to NF-kappaB activation. J. Biol. Chem.,
279:13469-77, 2004. PMID: 14724292
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HIV Raymond, A.D., Hasham, M., Tsygankov, A.Y.,
Henderson, E.E. Herpesvirus saimiri-encoded proteins Tip and StpC modulate
human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes
independently of viral tropism. Virology. 324:60-6, 2004. PMID: 15183053
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Dangelmaier, C.A., Quinter, P.G., Jin, J.,
Tsygankov, A.Y., Kunapuli, S.P., Daniel, J.L. Rapid ubiquitination of Syk
following GPVI activation in platelets. Blood, 105:3918-3924, 2005. PMID:
15701717
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Teckchandani, A.M., Panetti, T.S., Tsygankov,
A.Y. c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via
Rac1. Exp Cell Res 307, 247-258, 2005.PMID: 15922744
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Swaminathan, G., Tsygankov, A.Y. The Cbl family
proteins: ring leaders in regulation of cell signaling. J Cell Physiol 209,
21-43, 2006.PMID: 16741904
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HIV Raymond, A.D., Hasham, M., Tsygankov, A.Y.,
Henderson, E.E. H. saimiri tyrosine-kinase interacting protein inhibits Tat
function: a prototypic strategy for restricting HIV-1-induced cytopathic
effects in immune cells. Virology. 352:253-67, 2006. PMID: 16780912
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HIV Turner, L.S., Tsygankov, A.Y., Henderson,
E.E. StpC-based gene therapy targeting latent reservoirs of HIV-1. Antiviral
Res. 72:233-41, 2006. PMID: 16891001
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Swaminathan, G., Feshchenko, E.A. Tsygankov, A.Y.
c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are
regulated by membrane association of c-Cbl. Oncogene, 26:4095-105, 2007. PMID:
17237826
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Collingwood, T.S., Smirnova, E.V., Bogush, M.,
Carpino, N., Annan, R.S., Tsygankov, A.Y. TULA affects cell death through a
functional interaction with AIF, a key factor of caspase-independent apoptosis.
J. Biol. Chem. 282:30920-30928, 2007. PMID: 17709377
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HIV Raymond, A.D., Hasham, M., Tsygankov, A.Y.,
Henderson, E.E. Herpesvirus saimiri terminal membrane proteins modulate HIV-1
replication by altering Nef and Tat functions. Curr HIV Res. 5:79-86, 2007.
PMID: 17266559
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HIV Smirnova, E.V., Collingwood, T.S.,
Tsygankova, O.M., Bogush, M., Meinkoth, J., Bisbal, C., Annan, R.S., Tsygankov,
A.Y. The SH3- and UBA-containing protein TULA binds to ABCE-1, a host factor of
HIV-1 assembly, and inhibits HIV-1 biogenesis. Virology, 372:10-23, 2008. PMID:
18006034
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Agrawal, R., Carpino, N., Tsygankov, A. TULA
proteins regulate activity of the protein tyrosine kinase Syk. J. Cell.
Biochem. 104:953-964, 2008. PMID: 18189269
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Lee, H., Gaughan, J.P., Tsygankov, A.Y. c-Cbl
facilitates cytoskeletal effects in v-Abl transformed fibroblast through
Rac1-and Rap1-mediated signaling. Int. J. Biochem. Cell Biol. 40:1930-1943,
2008. PMID: 18403249
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Tsygankov, A.Y. Multidomain STS/TULA proteins are
novel cellular regulators. IUBMB Life. 60:224-231, 2008. PMID: 1834418
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Tsygankov, A.Y. TULA-family proteins: an odd
couple. Cell Mol Life Sci. 66:2949-2952, 2009. PMID: 19585081.
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HIV Tsygankov, A.Y Current developments in
anti-HIV/AIDS gene therapy. Curr Opin Investig Drugs. 10:137-49, 2009.PMID:
19197791
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Adapala, N.S., Barbe, M.F., Langdon, W.Y.,
Tsygankov, A.Y., Sanjay, A. Cbl-phosphatidylinositol 3 kinase interaction
differentially regulates macrophage colony-stimulating factor-mediated
osteoclast survival and cytoskeletal reorganization. Ann N Y Acad Sci.
1192:376-384, 2010. PMID: 20392263
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Daniel, J.L., Dangelmaier, C.A., Mada, S.,
Buitrago, L., Jin, J., Langdon, W.Y., Tsygankov, A.Y., Kunapuli, S.P., Sanjay,
A. Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet
activation. J Biol Chem. 285:17282-17291, 2010. PMID: 20400514
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Thomas, D.H., Getz,T.M., Newman, T.N.,
Dangelmaier,C.A., Carpino, N., Kunapuli, S.P., Tsygankov,A.Y.*, Daniel, J.L.*A
Novel histidine tyrosine phosphatase, TULA-2, associates with Syk and
negatively regulates GPVI signaling in platelets. Blood, 116:2570-8, 2010.
PMID: 20585042
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Chen, X., Ren, L., Kim, S., Carpino, N., Daniel,
J.L., Kunapuli, S.P., Tsygankov, A.Y.*, Pei, D.* Determination of the substrate
specificity of protein tyrosine phosphatase TULA-2 and identification of Syk as
a TULA-2 substrate. J Biol Chem. 285:31268-7, 2010. PMID: 20670933
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Adapala, N.S., Barbe, M.F., Langdon, W.Y.,
Nakamura, M.C., Tsygankov, A.Y., Sanjay, A. The loss of
Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated
signaling, inhibiting bone resorption and promoting osteoclast survival. J Biol
Chem. 285:36745-58, 2010. PMID: 20851882
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Lee, H, Tsygankov, A.Y. c-Cbl regulates glioma
invasion through matrix metalloproteinase 2. J Cell Biochem. 111:1169-78, 2010.
PMID: 20717917