Dr. Julio Martín-García

Drexel University, USA

Email: julio.martin-garcia@drexelmed.edu

Qualifications

1997  Ph.D., Universidad Autónoma of Madrid, Spain

1990  B.Sc., Universidad Complutense of Madrid, Spain

Publications (Selected)

1. Navas S, Martín J, Quiroga JA, Castillo I, Carreño V. Genetic diversity and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients. Journal of Virology 1998; 72: 1640-1646.
2. Martín J, Navas S, Quiroga JA, Colucci G, Pardo M, Carreño V. Quantitation of hepatitis C virus (HCV) RNA in liver and peripheral blood mononuclear cells from patients with chronic HCV infection. Journal of Medical Virology 1998; 54: 265-270.
3. Martín J, Navas S, Quiroga JA, Pardo M, Carreño V. Effects of the ribavirin-interferon a combination on cultured peripheral blood mononuclear cells from chronic hepatitis C patients. Cytokine 1998; 10: 635-644.
4. Martín J, Navas S, Fernández M, Rico M, Pardo M, Quiroga JA, Zahm F, Carreño V. Antiviral effect of amantadine and interferon a-2a against hepatitis C virus on peripheral blood mononuclear cells from chronic hepatitis C patients. Antiviral Research 1999; 42: 59-70.
5. Shieh JTC, Martín J, Baltuch G, Malim MH, González-Scarano F. Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domains. Journal of Virology 2000; 74: 693-701.
6. Albright AV, Martín J, O’Connor M, González-Scarano F. Interactions between HIV-1 gp120, chemokines, and cultured adult microglial cells. Journal of Neurovirology 2001; 7: 196-207.
7. Martín J, LaBranche CC, González-Scarano F. Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate. Journal of Virology 2001; 75: 3568-3580.
8. Martín-García J, Kolson DL, González-Scarano F. Chemokine receptors in the brain: their role in HIV infection and pathogenesis. AIDS 2002; 16: 1709-1730.
9. González-Scarano F, Martín-García J. The neuropathogenesis of AIDS. Nature Reviews Immunology 2005; 5: 69-81.
10. Martín-García J, Cocklin S, Chaiken IM, González-Scarano F. Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglia-adapted human immunodeficiency virus type 1 isolate. Journal of Virology 2005, 79: 6703-6713.
11. Plassmeyer ML, Soldan SS, Stachelek KM, Martín-García J, González-Scarano F. California serogroup Gc (G1) glycoprotein is the principal determinant of pH-dependent cell fusion and entry. Virology 2005, 338: 121-132.
12. Martín-García J, Cao W, Varela-Rohena A, Plassmeyer ML, González-Scarano F. HIV-1 tropism for the central nervous system: brain-derived envelope glycoproteins with lower CD4-dependence and reduced sensitivity to a fusion inhibitor. Virology 2006, 346: 169-179.
13. Chen MF, Westmoreland S, Ryzhova EV, Martín-García J, Soldan SS, Lackner A, González-Scarano F. Simian immunodeficiency virus envelope compartmentalizes in brain regions independent of neuropathology. Journal of Neurovirology 2006, 12: 73-89.
14. Plassmeyer ML, Soldan SS, Stachelek KM, Roth SM, Martín-García J, González-Scarano F. Mutagenesis of the La Crosse virus glycoprotein supports a role for Gc (1066-1087) as the fusion peptide. Virology 2007, 358: 273-282.
15. Cocklin S, Gopi H, Querido B, Nimmagadda M, Kuriakose S, Cicala C, Ajith S, Baxter S, Arthos J, Martín-García J, Chaiken IM. Broad-spectrum anti-HIV potential of a peptide HIV-1 entry inhibitor. Journal of Virology 2007, 81: 3645-3648.
16. Rossi F, Querido B, Nimmagadda D, Cocklin S, Navas-Martín S, Martín-García J. The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors. Retrovirology 2008, 5:89.
17. Rajagopalan N, Suchitra JB, Shet A, Khan ZK, Martín-García J, Nonnemacher MR, Jacobson JM, Wigdahl B.  Mortality among HIV-infected patients in resource limited settings: A case controlled analysis of inpatients at a community care center.  American Journal of Infectious Diseases 2009, 5: 226-231.
18. Li L, Aiamkitsumrit B, Pirrone V, Nonnemacher MR, Wojno A, Passic S, Flaig K, Kilareski E, Blakey B, Ku J, Parikh N, Shah R, Martín-García J, Moldover B, Servance L, Downie D, Lewis S, Jacobson JM, Kolson D, Wigdahl B. Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment. Journal of Neurovirology 2011; 17:92-109.