Advances in Pediatric Medulloblastoma

Medulloblastoma is a common type of primary brain cancer in children. It originates in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa. Medulloblastomas are invasive, rapidly growing tumors that, unlike most brain tumors, spread through the cerebrospinal fluid and frequently metastasize to different locations along the surface of the brain and spinal cord. Metastasis all the way down to the cauda equina at the base of the spinal cord is termed "drop metastasis".

In the present book, twelve typical literatures about pediatric medulloblastoma published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on pediatric medulloblastoma. We hope this book can demonstrate advances in pediatric medulloblastoma as well as give references to the researchers, students and other related people.

Sample Chapter(s)
preface (95 KB)
Components of the Book:
  • Chapter 1
    Subtyping of Group 3/4 medulloblastoma as a potential prognostic biomarker among patients treated with reduced dose of craniospinal irradiation: a Japanese Pediatric Molecular Neuro‑Oncology Group study
  • Chapter 2
    Prognostic value of microRNA‑125a expression status in molecular groups of pediatric medulloblastoma
  • Chapter 3
    Radiomic‑ and dosiomic‑based clustering development for radio‑induced neurotoxicity in pediatric medulloblastoma
  • Chapter 4
    Outcomes of a radiation sparing approach in medulloblastoma by subgroup in young children: an institutional review
  • Chapter 5
    Mass spectrometry‑based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta‑analysis of individual patient data
  • Chapter 6
    Outcomes of intraventricular 131‑I‑omburtamab and external beam radiotherapy in patients with recurrent medulloblastoma and ependymoma
  • Chapter 7
    Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism‑dependent vulnerabilities in medulloblastoma
  • Chapter 8
    IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma
  • Chapter 9
    MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
  • Chapter 10
    The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma
  • Chapter 11
    Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC‑amplified medulloblastoma cells
  • Chapter 12
    Dynamic profiling of medulloblastoma surfaceome
Readership: Students, academics, teachers and other people attending or interested in Pediatric Medulloblastoma.
Stefano Piffer
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence,Italy

Rebecca Ronsley
Division of Hematology, Oncology & Bone Marrow Transplant, department of Pediatrics, Seattle Children’s Hospital and the University of Washington, Seattle, WA, USA

Kathryn R. Tringale
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

and more...
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