Infectomics: Holo-Omics Studies on Microbial Infections
Infectomics has become one of the original members of the medical “omics” family since the completion of the Human Genome Project. The first paper that was accepted for publication on this emerging discipline was in 2001 in the first issue of Functional and Integrative Genomics. It was also published in Nature Encyclopedia of Human Genome in 2003. These early publications serve as the foundation of this book, along with papers I have published over the past 18 years while studying Infectomics. This book focuses on holo-omic studies of microbial infections, and is structured into five parts that explore the history of Infectomics, its major issues.
Sample Chapter(s)
Preface (57 KB)
Components of the Book:
  • PREFACE
  • CONTENTS
  • Chapter 1
    Overture: Why Infectomics?
  • Chapter 2
    Infectomics: Genomics and Proteomics of Microbial Infections
  • Chapter 3
    Infectomics: Study of Response to Infection Using Microarrys
  • Chapter 4
    Infectomic Analysis of Microbial Infections Using Proteomics
  • Chapter 5
    Infectomics Overview: Holistical and Integrative Studies of Infectious Diseases
  • Chapter 6
    Infectomics: Study of Microbial Infections Using Omic Approaches
  • Chapter 7
    Infectomic Analysis of Gene Expression Profiles of Human Brain Microvascular Endothelial Cells Infected with Cryptococcus neoformans
  • Chapter 8
    Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections
  • Chapter 9
    Duality Natures of the Genetic Island GimA
  • Chapter 10
    Ecological Infectomics (Ecoinfectomics): Symbiotic Solutions to Microbial Infections
  • Chapter 11
    Lactobacillus rhamnosus GG Suppresses Meningitic E. coli K1 Penetration across Human Intestinal Epithelial Cells in Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis
  • Chapter 12
    Mucin2 Is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities
  • Chapter 13
    Exploring Novel Immunological Interventions Using Immunoinfectomics
  • Chapter 14
    Mathematical Modeling of Cytotoxic Lymphocyte-Mediated Immune Response to Hepatitis B Virus Infection
  • Chapter 15
    Chemoinfectomics in Drug Design and Development
  • Chapter 16
    Infectomics in the Discovery and Development of New Antimicrobial Agents
  • Chapter 17
    Blood-Brain Barrier Drug Discovery for Central Nervous System Infections
  • Chapter 18
    The Evolving Role of Infectomics in Drug Discovery
Readership: Students, academics, teachers and other people attending or interested in Holo-Omics Studies on Microbial Infections
1
PREFACE
Sheng-He Huang
PDF (57 KB)
5
CONTENTS
Sheng-He Huang
PDF (356 KB)
7
Chapter 1
Overture: Why Infectomics?

Sheng-He Huang
PDF (678 KB)
24
Chapter 2
Infectomics: Genomics and Proteomics of Microbial Infections

Sheng-He Huang
PDF (17313 KB)
39
Chapter 3
Infectomics: Study of Response to Infection Using Microarrys

Sheng-He Huang
PDF (48 KB)
46
Chapter 4
Infectomic Analysis of Microbial Infections Using Proteomics

Sheng-He Huang
PDF (9116 KB)
57
Chapter 5
Infectomics Overview: Holistical and Integrative Studies of Infectious Diseases

Sheng-He Huang
PDF (5776 KB)
78
Chapter 6
Infectomics: Study of Microbial Infections Using Omic Approaches

Sheng-He Huang
PDF (47 KB)
87
Chapter 7
Infectomic Analysis of Gene Expression Profiles of Human Brain Microvascular Endothelial Cells Infected with Cryptococcus neoformans

Sheng-He Huang
PDF (4399 KB)
96
Chapter 8
Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections

Sheng-He Huang
PDF (5077 KB)
105
Chapter 9
Duality Natures of the Genetic Island GimA

Sheng-He Huang
PDF (913 KB)
117
Chapter 10
Ecological Infectomics (Ecoinfectomics): Symbiotic Solutions to Microbial Infections

Sheng-He Huang
PDF (2543 KB)
126
Chapter 11
Lactobacillus rhamnosus GG Suppresses Meningitic E. coli K1 Penetration across Human Intestinal Epithelial Cells in Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis

Sheng-He Huang
PDF (4385 KB)
134
Chapter 12
Mucin2 Is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities

Sheng-He Huang
PDF (7214 KB)
145
Chapter 13
Exploring Novel Immunological Interventions Using Immunoinfectomics

Sheng-He Huang
PDF (3417 KB)
153
Chapter 14
Mathematical Modeling of Cytotoxic Lymphocyte-Mediated Immune Response to Hepatitis B Virus Infection

Sheng-He Huang
PDF (3721 KB)
163
Chapter 15
Chemoinfectomics in Drug Design and Development

Sheng-He Huang
PDF (3921 KB)
174
Chapter 16
Infectomics in the Discovery and Development of New Antimicrobial Agents

Sheng-He Huang
PDF (4854 KB)
186
Chapter 17
Blood-Brain Barrier Drug Discovery for Central Nervous System Infections

Sheng-He Huang
PDF (3215 KB)
195
Chapter 18
The Evolving Role of Infectomics in Drug Discovery

Sheng-He Huang
PDF (2807 KB)
Sheng-He Huang, University of Southern California
Graduated from Chinese Academy of Medical Sciences/ Peking Union Medical College and College of Life Science and Technology, Huazhong University of Science & Technology (HUST). Emeritus Professor, Department of Pediatrics, University of Southern California, Keck School of Medicine; Visiting Professor, School of Public Health Southern Medical University, Guangzhou, China; Visiting Professor, KingMed College of Laboratory Medicine Guangzhou Medical University, Guangzhou, China.

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