The author began to understand the molecular mechanisms underlying regulation of hormone and metabolism in 1996 when he completed my bachelor’s degree in the Department of Clinical Medicine in Tianjin Medical University and began my master’s degree in the National Key Laboratory of Hormone and Brain Development, Tianjin Institute of Endocrinology. After getting his master’s degree in Biochemistry in 1999, he went to the University of Florida, one of the public Ivy League in the United States, to pursue his doctor’s degree in the Department of Neuroscience, College of Medicine. During the next five years, he systematically learned and studied, from the neuroscience and molecular biology perspectives, the retina, one of the most important tissues at the posterior part of the eye. After acquiring his Ph.D. degree as one of the outstanding graduate students in 2004, he started his brief 1st round of postdoctoral training. He went to Pennington Biomedical Research Center in the United Sytates in 2007 to receive his 2nd and 3rd rounds of postdoctoral training in the Department of Neuroscience and the Department of Neurobiology, respectively. His work during this period focused on the molecular interactions between the signaling pathways mediated by ɑ-melanocyte-stimulating hormone (ɑ-MSH) and leptin at the interface of blood-brain barrier as well as the neural circuits regulating the physiological functions of ɑ-MSH and leptin in the hypothalamus. He came back to his hometown Tianjin, China in 2010 and started to work as a full Professor and Principal Investigator in the Laboratory of Translational Medicine. He adjusted his research direction to the novel molecular interventions to retinal diseases and their mechanisms of action by integrating the knowledge and expertise during his training and education. Ten years have passed since he followed this direction. His research group has published a number of papers on the protective effects of ɑ-MSH in several animal models of eye diseases, such as the rat models of diabetic retinopathy and dry eye, the mouse model of retinopathy of prematurity, and the chick model of glutamate-induced retinal excitotoxicity. He feel it necessary to summarize these results and integrate them with the current advances, thereby offering the scholars, graduate students, and medical doctors a monograph on ɑ-MSH in the field of eye research.
Components of the Book:
- Head Page
- Copyright
- Preface
- Content
- Chapter 1.Expression of α-Melanocyte-Stimulating Hormone and Melanocortin Receptors
- 1.Generation of α-Melanocyte-Stimulating Hormone
- 2.Systemic and Ocular Distribution of α-MSH
- 3.Distribution of Melanocortin Receptors
- References
- Chapter 2.Physiological Functions of α-Melanocyte-Stimulating Hormone
- 1.Regulation of Skin Physiology and Eye Pigmentation by α-MSH
- 2.Immune System
- 3.Nervous System
- References
- Chapter 3.The Role of α-MSH in Ocular Surface Diseases
- 1.Application of α-MSH in Dry Eye
- 2.Application of α-MSH in Cornea Injury
- 3.Application of α-MSH in Cornea Anti-Lymphangiogenesis
- References
- Chapter 4.The Role of α-MSH in Uveitis and Uveal Melanoma
- 1.The Role of α-MSH in Uveitis
- 2.The Effects of α-MSH on Uveal Melanoma
- References
- Chapter 5.The Role of α-MSH on Blood-Aqueous Barrier, Intraocular Pressure, and Lens
- 1.Effects and Mechanism of α-MSH on Blood-Aqueous Barrier
- 2.The Regulation of α-MSH on Intraocular Pressure
- 3.The Effect of α-MSH on Lens
- References
- Chapter 6.The Application of α-MSH in Retinal Diseases
- 1.Regulation of α-MSH in Diabetic Retinopathy
- 2.Role of α-MSH in Retinal Ischemia/Reperfusion
- 3.Role of α-MSH in Glutamate-Induced Excitotoxicity
- 4.Regulation of α-MSH in Age-Related Macular
Degeneration
- 5.Regulation of α-MSH in Retinal Dystrophy
- References
- Chapter 7.The Role of α-MSH in Neovascular Eye Diseases
- 1.Vascular Development and Blood Supply of Eyes
- 2.Pathophysiology of Neovascularization
- 3.Angiogenesis-Related Factors
- 4.The Role of α-MSH in Neovascular Eye Diseases
- References
- Acknowledgement
Readership:
Readers who are interested in α-melanocyte-stimulating hormone in eye diseases
Zhang Yan
Yan Zhang, male, 47 years old, Professor, Principle Investigator of the Laboratory of Translational Medicine, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital.