Changes of IL-1, TNF-Alpha, IL-12 and IL-10 Levels with Chronic Liver Failure ()
Abstract
[Aim] To investigate the action of cytokines in patients with chronic liver failure and to explore the roles of cytokines in chronic liver failure. [Methods] Thirty-one patients with chronic liver failure admitted from May 2006 to November 2009 were included. Thirty cases with mild to moderate chronic type B hepatitis admitted concomitantly were regarded as control. IL-1, TNF-alpha, IL-12, IL-10 Levels in serum was the factors to determine at clinical diagnosis and 2-week treatment. We analyzed levels of cytokines action in 31 chronic liver failure patients both at clinical diagnosis and 2-week treatment in comparison with control group. [Results] We analyzed IL-1 level in death group at clinical diagnosis and 2-week treatment were sig- nificant higher than in survival and control groups, furthermore it was also higher in survival group than in control group. At clinical diagnosis, TNF-alpha level in death group was higher than that in control. How- ever, there was no obviously difference between the death group and the survival group in TNF-alpha level. With the progression of the disease, TNF-alpha level was remarkably risen in death group, but decreased in survival group. IL-10 level was dramatically increased in death group, but no changed in survival group. IL-12 level in death group was higher than in survival group, but lower than in control group. [Conclusions] The levels of TNF-alpha, IL-1, IL-10 and IL-12 in patients with chronic liver failure was increased and the increase of IL-10 is secondary to elevation of IL-12.
Share and Cite:
G. Liu, K. Tang, Q. Li, G. Yuan, W. Cao and W. Lu, "Changes of IL-1, TNF-Alpha, IL-12 and IL-10 Levels with Chronic Liver Failure,"
Surgical Science, Vol. 2 No. 2, 2011, pp. 69-72. doi:
10.4236/ss.2011.22015.
Conflicts of Interest
The authors declare no conflicts of interest.
References
[1]
|
H. Isoniemi, A. M. Koivusalo, H. Repo and et a1. “The Effect of Albumin Dialysis on Cytokine Levels in Acute Liver Failure and Need for Liver Transplantation,” Transplantation Proceedings, Vol. 37, No. 2, 2005, pp. 1088-1090. doi:10.1016/j.transproceed.2004.11.060
|
[2]
|
Tao Wen and Hao Wu, “Research Progress of Interleukin-12 and Its Application in Management of HIV Infection,” Foreign Medical Sciences (Epidemiology Lemology Fascicle), Vol. 30, No. 5, 2003, pp. 271-274.
|
[3]
|
J. Clin Hepatol, “Diagnostic and treatment guidelines for liver failure,” Vol. 9, No. 6, 2006.
|
[4]
|
R. F. Schwabe and D. A. Brenner, “Mechanisms of Liver Injury Tnf-Alpha-Induced Liver Injury: Role of IKK, JNK, and ROS Pathways,” American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 290, No. 4, 2006, pp. 583-589. doi:10.1152/ajpgi.00422.2005
|
[5]
|
E. Yumoto, T. Higashi and K. Nouso, “Serum Gamma-Interferon-Inducing Factor (Il-18) and IL-10 Levels in Patients with Acute Hepatitis and Fulminant Hepatic Failure,” Journal of Gastroenterology and Hepatology, Vol. 17, 2002, pp. 285-294.
doi:10.1046/j.1440-1746.2002.02690.x
|