[1]
|
McGeer, E.G. and McGeer, P.L. (2010) Neuroinflammation in Alzheimer’s Disease and Mild Cognitive Impairment: A Field in Its Infancy. Journal of Alzheimer’s Disease, 19, 355-361.
|
[2]
|
Qian, L., Flood, P.M. and Hong, J.S. (2010) Neuroinflammation is a Key Player in Parkinson’s Disease and a Prime Target for Therapy. Journal of Neural Transmission, 117, 971-979. http://dx.doi.org/10.1007/s00702-010-0428-1
|
[3]
|
Broussard, G.J., Mytar, J., Li, R.C. and Klapstein, G.J. (2012) The Role of Inflammatory Processes in Alzheimer’s Disease. Inflammopharmacology, 20, 109-126.
|
[4]
|
Luessi, F., Siffrin, V. and Zipp, F. (2012) Neurodegeneration in Multiple Sclerosis: Novel Treatment Strategies. Expert Review of Neurotherapeutics, 12, 1061-1076. http://dx.doi.org/10.1586/ern.12.59
|
[5]
|
Rao, J.S., Kellom, M., Kim, H.W., Rapoport, S.I. and Reese, E.A. (2012) Neuroinflammation and Synaptic Loss. Neurochemical Research, 37, 903-910. http://dx.doi.org/10.1007/s11064-012-0708-2
|
[6]
|
Blandini, F. (2013) Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease. Journal of Neuro-Immune Pharmacology, 8, 189-201. http://dx.doi.org/10.1007/s11481-013-9435-y
|
[7]
|
Breunig, J.J., Guillot-Sestier, M.V. and Town, T. (2013) Brain Injury, Neuroinflammation and Alzheimer’s Disease. Frontiers in Aging Neuroscience, 11, 26.
|
[8]
|
Enciu, A.M. and Popescu, B.O. (2013) Is There a Causal Link between Inflammation and Dementia? BioMed Research International, 2013, 316495. http://dx.doi.org/10.1155/2013/316495
|
[9]
|
Ownby, R.L. (2010) Neuroinflammation and Cognitive Aging. Current Psychiatry Reports, 12, 39-45.
http://dx.doi.org/10.1007/s11920-009-0082-1
|
[10]
|
Pizza, V., Agresta, A., D’Acunto, C.W., Festa, M. and Capasso, A. (2011) Neuroinflammation and Ageing: Current Theories and an Overview of the Data. Reviews on Recent Clinical Trials, 6, 189-203.
http://dx.doi.org/10.2174/157488711796575577
|
[11]
|
Cagnin, A., Brooks, D.J., Kennedy, A.M., Gunn, R.N., Myers, R. and Turkheimer, F.E. (2001) In-Vivo Measurement of Activated Microglia in Dementia. Lancet, 358, 461-467. http://dx.doi.org/10.1016/S0140-6736(01)05625-2
|
[12]
|
Butcher, S.K. and Lord, J.M. (2004) Stress Responses and Innate Immunity: Aging as a Contributory Factor. Aging Cell, 3, 151-160. http://dx.doi.org/10.1111/j.1474-9728.2004.00103.x
|
[13]
|
Eikelenboom, P., van Exel, E., Hoozemans, J.J., Veerhuis, R., Rozemuller, A.J. and van Gool, W.A. (2010) Neuroinflammation—An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease. Neurodegenerative Diseases, 7, 38-41. http://dx.doi.org/10.1159/000283480
|
[14]
|
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.G. and Zhu, X. (2013) Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease. Biochimica et Biophysica Acta, S0925-4439(13)00323-2.
|
[15]
|
Katafuchi, T., Ifuku, M., Mawatari, S., Noda, M., Miake, K., Sugiyama, M. and Fujino, T. (2012) Effects of Plasmalogens on Systemic Lipopolysaccharide-Induced Glial Activation and β-Amyloid Accumulation in Adult Mice. Annals of the New York Academy of Sciences, 1262, 85-92. http://dx.doi.org/10.1111/j.1749-6632.2012.06641.x
|
[16]
|
Krstic, D., Madhusudan, A., Doehner, J., Vogel, P., Notter, T., Imhof, C., Manalastas, A., Hilfiker, M., Pfister, S., Schwerdel, C., Riether, C., Meyer, U. and Knuesel, I. (2012) Systemic Immune Challenges Trigger and Drive Alzheimer- Like Neuropathology in Mice.Journal of Neuroinflammation, 9, 151. http://dx.doi.org/10.1186/1742-2094-9-151
|
[17]
|
Kraft, A.W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wan, Y., Gil, S.C., Brown, J., Wilhelmsson, U., Restivo, J.L., Cirrito, J.R., Holtzman, D.M., Kim, J., Pekny, M. and Lee, J.M. (2013) Attenuating Astrocyte Activation Accelerates Plaque Pathogenesis in APP/PS1 Mice. FASEB Journal, 27, 187-198. http://dx.doi.org/10.1096/fj.12-208660
|
[18]
|
Medeiros, R. and LaFerla, F.M. (2013) Astrocytes: Conductors of the Alzheimer Disease Neuroinflammatory Symphony. Experimental Neurology, 239, 133-138. http://dx.doi.org/10.1016/j.expneurol.2012.10.007
|
[19]
|
Zhao, J., O’Connor, T. and Vassar, R. (2011) The Contribution of Activated Astrocytes to Aβ Production: Implications for Alzheimer’s Disease Pathogenesis. Journal of Neuroinflammation, 8, 150.
http://dx.doi.org/10.1186/1742-2094-8-150
|
[20]
|
Sondag, C.M., Dhawan, G. and Combs, C.K. (2009) Beta Amyloid Oligomers and Fibrils Stimulate Differential Activation of Primary Microglia. Journal of Neuroinflammation, 6, 1. http://dx.doi.org/10.1186/1742-2094-6-1
|
[21]
|
Maezawa, I., Zimin, P.I., Wulff, H. and Jin, L.W. (2011) Amyloid-Beta Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity. Journal of Biological Chemistry, 286, 3693-3706.
http://dx.doi.org/10.1074/jbc.M110.135244
|
[22]
|
DeKosky, S.T. and Scheff, S.W. (1990) Synapse Loss in Frontal Cortex Biopsies in Alzheimer’s Disease: Correlation with Cognitive Severity. Annals of Neurology, 27, 457-464. http://dx.doi.org/10.1002/ana.410270502
|
[23]
|
Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., Deteresa, R., Hill, R., Hansen, L.A. and Katzman, R. (1991) Physical Basis of Cognitive Alterations in Alzheimer’s Disease: Synapse Loss Is the Major Correlate of Cognitive Impairment. Annals of Neurology, 30, 572-580.
http://dx.doi.org/10.1002/ana.410300410
|
[24]
|
Masliah, E., Mallory, M., Alford, M., DeTeresa, R., Hansen, L.A., McKeel Jr., D.W. and Morris, J.C. (2001) Altered Expression of Synaptic Proteins Occurs Early during Progression of Alzheimer’s Disease. Neurology, 56, 127-129.
http://dx.doi.org/10.1212/WNL.56.1.127
|
[25]
|
Heinonen, O., Soininen, H., Sorvari, H., Kosunen, O., Paljarvi, L., Koivisto, E. and Riekkinen, P.J. (1995) Loss of Synaptophysin-Like Immunoreactivity in the Hippocampal Formation Is an Early Phenomenon in Alzheimer’s Disease. Neuroscience, 64, 375-384. http://dx.doi.org/10.1016/0306-4522(94)00422-2
|
[26]
|
Reddy, P.H., Mani, G., Park, B.S., Jacques, J., Murdoch, G., Whetsell Jr., W., Kaye, J. and Manczak, M. (2005) Differential Loss of Synaptic Proteins in Alzheimer’s Disease: Implications for Synaptic Dysfunction. Journal of Alzheimer’s Disease, 7, 103-117.
|
[27]
|
Scheff, S.W., Price, D.A., Schmitt, F.A., Scheff, M.A. and Mufson, E.J. (2011) Synaptic Loss in the Inferior Temporal Gyrus in Mild Cognitive Impairment and Alzheimer’s Disease. Journal of Alzheimer’s Disease, 24, 547-557.
|
[28]
|
D’Amelio, M. and Rossini, P.M. (2012) Brain Excitability and Connectivity of Neuronal Assemblies in Alzheimer’s Disease: From Animal Models to Human Findings. Progress in Neurobiology, 99, 42-60.
http://dx.doi.org/10.1016/j.pneurobio.2012.07.001
|
[29]
|
Berchtold, N.C., Coleman, P.D., Cribbs, D.H., Rogers, J., Gillen, D.L. and Cotman, C.W. (2013) Synaptic Genes Are Extensively Downregulated across Multiple Brain Regions in Normal Human Aging and Alzheimer’s Disease. Neurobiology of Aging, 34, 1653-1661. http://dx.doi.org/10.1016/j.neurobiolaging.2012.11.024
|
[30]
|
Knobloch, M. and Mansuy, I.M. (2008) Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease. Mole-cular Neurobiology, 37, 73-82.
http://dx.doi.org/10.1007/s12035-008-8018-z
|
[31]
|
Kanaan, N.M., Pigino, G.F., Brady, S.T., Lazarov, O., Binder, L.I. and Morfini, G.A. (2013) Axonal Degeneration in Alzheimer’s Disease: When Signaling Abnormalities Meet the Axonal Transport System. Experimental Neurology, 246, 44-53. http://dx.doi.org/10.1016/j.expneurol.2012.06.003
|
[32]
|
Yan, X.X., Ma, C., Gai, W.P., Cai, H. and Luo, X.G. (2014) Can BACE1 Inhibition Mitigate Early Axonal Pathology in Neurological Diseases? Journal of Alzheimer’s Disease, 38, 705-718.
|
[33]
|
Zhang, X.M., Cai, Y., Xiong, K., Cai, H., Luo, X.G., Feng, J.C., Clough, R.W., Struble, R.G., Patrylo, P.R. and Yan, X.X. (2009) β-Secretase-1 Elevation in Transgenic Mouse Models of Alzheimer’s Disease Is Associated with Synaptic/ Axonal Pathology and Amyloidogenesis: Implications for Neuritic Plaque Development. European Journal of Neuroscience, 30, 2271-2283. http://dx.doi.org/10.1111/j.1460-9568.2009.07017.x
|
[34]
|
Cai, Y., Zhang, X.M., Macklin, L.N., Cai, H., Luo, X.G., Oddo, S., Laferla, F.M., Struble, R.G., Rose, G.M., Patrylo, P.R. and Yan, X.X. (2012) BACE1 Elevation Is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimer’s Disease: Differential Aβ Antibody Labeling of Early-Onset Axon Terminal Pathology. Neurotoxicity Research, 21, 160-174. http://dx.doi.org/10.1007/s12640-011-9256-9
|
[35]
|
Li, J.M., Xue, Z.Q., Deng, S.H., Luo, X.G., Patrylo, P.R., Rose, G.W., Cai, H., Cai, Y. and Yan, X.X. (2013) Amyloid Plaque Pathogenesis in 5XFAD Mouse Spinal Cord: Retrograde Transneuronal Modulation after Peripheral Nerve Injury. Neurotoxicity Research, 24, 1-14. http://dx.doi.org/10.1007/s12640-012-9355-2
|
[36]
|
Xu, J. and Ling, E.A. (1994) Upregulation and Induction of Surface Antigens with Special Reference to MHC Class II Expression in Microglia in Postnatal Rat Brain Following Intravenous or Intraperitoneal Injections of Lipopolysaccharide. Journal of Anatomy, 184, 285-296.
|
[37]
|
Hauss-Wegrzyniak, B., Dobrzanski, P., Stoerh, J.D. and Wenk, G.L. (1998) Chronic Neuroinflammation in Rats Re produces Components of the Neurobiology of Alzheimer’s Disease. Brain Research, 780, 294-303.
http://dx.doi.org/10.1016/S0006-8993(97)01215-8
|
[38]
|
Sugaya, K., Chou, S., Xu, S.J. and McKinney, M. (1998) Indicators of Glial Activation and Brain Oxidative Stress after Intraventricular Infusion of Endotoxin. Molecular Brain Research, 58, 1-9.
http://dx.doi.org/10.1016/S0169-328X(97)00365-3
|
[39]
|
Tanaka, S., Ide, M., Shibutani, T., Ohtaki, H., Numazawa, S., Shioda, S. and Yoshida, T. (2006) Lipopolysaccharide- Induced Microglial Activation Induces Learning and Memory Deficits without Neuronal Cell Death in Rats. Journal of Neuroscience Research, 83, 557-566. http://dx.doi.org/10.1002/jnr.20752
|
[40]
|
Lee, J.W., Lee, Y.K., Yuk, D.Y., Choi, D.Y., Ban, S.B., Oh, K.W. and Hong, J.T. (2008) Neuroinflammation Induced by Lipopolysaccharide Causes Cognitive Impairment through Enhancement of Beta-Amyloid Generation. Journal of Neuroinflammation, 5, 37. http://dx.doi.org/10.1186/1742-2094-5-37
|
[41]
|
Deng, X.H., Ai, W.M., Lei, D.L., Luo, X.G., Yan, X.X. and Li, Z. (2012) Lipopolysaccharide Induces Paired Immu- noglobulin-Like Receptor B (PirB) Expression, Synaptic Alteration, and Learning-Memory Deficit in Rats. Neuroscience, 209, 161-170. http://dx.doi.org/10.1016/j.neuroscience.2012.02.022
|
[42]
|
Laird, F.M., Cai, H., Savonenko, A.V., Farah, M.H., He, K., Melnikova, T., Wen, H., Chiang, H.C., Xu, G., Koliatsos, V.E., Borchelt, D.R., Price, D.L., Lee, H.K. and Wong, P.C. (2005) BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, Is Essential for Cognitive, Emotional, and Synaptic Functions. Journal of Neuroscience, 25, 11693-11709. http://dx.doi.org/10.1523/JNEUROSCI.2766-05.2005
|
[43]
|
Xiong, K., Cai, H., Luo, X.G., Struble, R.G., Clough, R.W. and Yan, X.X. (2007) Mitochondrial Respiratory Inhibition and Oxidative Stress Elevate β-Secretase (BACE1) Proteins and Activity in Vivo in the Rat Retina. Experimental Brain Research, 181, 435-446. http://dx.doi.org/10.1007/s00221-007-0943-y
|
[44]
|
Dutta, G., Zhang, P. and Liu, B. (2008) The Lipopolysaccharide Parkinson’s Disease Animal Model: Mechanistic Studies and Drug Discovery. Fundamental & Clinical Pharmacology, 22, 453-464.
http://dx.doi.org/10.1111/j.1472-8206.2008.00616.x
|
[45]
|
Lee, D.C., Rizer, J., Selenica, M.L., Reid, P., Kraft, C., Johnson, A., Blair, L., Gordon, M.N., Dickey, C.A. and Morgan, D. (2010) LPS-Induced Inflammation Exacerbates Phospho-Tau Pathology in rTg4510 Mice. Journal of Neuroinflammation, 7, 56. http://dx.doi.org/10.1186/1742-2094-7-56
|
[46]
|
Hoban, D.B., Connaughton, E., Connaughton, C., Hogan, G., Thornton, C., Mulcahy, P., Moloney, T.C. and Dowd, E. (2013) Further Characterisation of the LPS Model of Parkinson’s Disease: A Comparison of Intra-Nigral and Intra- Striatal Lipopolysaccharide Administration on Motor Function, Microgliosis and Nigrostriatal Neurodegeneration in the Rat. Brain, Behavior, and Immunity, 27, 91-100. http://dx.doi.org/10.1016/j.bbi.2012.10.001
|
[47]
|
Ifuku, M., Katafuchi, T., Mawatari, S., Noda, M., Miake, K., Sugiyama, M. and Fujino, T. (2012) Anti-Inflammatory/ Anti-Amyloidogenic Effects of Plasmalogens in Lipopolysaccharide-Induced Neuroinflammation in Adult Mice. Journal of Neuroinflammation, 9, 197. http://dx.doi.org/10.1186/1742-2094-9-197
|
[48]
|
Martin, S.A., Pence, B.D., Greene, R.M., Johnson, S.J., Dantzer, R., Kelley, K.W. and Woods, J.A. (2013) Effects of Voluntary Wheel Running on LPS-Induced Sickness Behavior in Aged Mice. Brain, Behavior, and Immunity, 29, 113- 123. http://dx.doi.org/10.1016/j.bbi.2012.12.014
|
[49]
|
Samanani, S., Mishra, M., Silva, C., Verhaeghe, B., Wang, J., Tong, J. and Yong, V.W. (2013) Screening for Inhibitors of Microglia to Reduce Neuroinflammation. CNS & Neurological Disorders-Drug Targets, 12, 741-749.
http://dx.doi.org/10.2174/18715273113126660177
|
[50]
|
Asti, A. and Gioglio, L. (2014) Can a Bacterial Endotoxin Be a Key Factor in the Kinetics of Amyloid Fibril Formation? Journal of Alzheimer’s Disease, 39, 169-179.
|
[51]
|
Morga, E., Faber, C. and Heuschling, P. (1999) Regional Heterogeneity of the Astroglial Immunoreactive Phenotype: Effect of Lipopolysaccharide. Journal of Neuroscience Research, 57, 941-952.
http://dx.doi.org/10.1002/(SICI)1097-4547(19990915)57:6<941::AID-JNR20>3.0.CO;2-Z
|
[52]
|
Hauss-Wegrzyniak, B., Lynch, M.A., Vraniak, P.D. and Wenk, G.L. (2002) Chronic Brain Inflammation Results in Cell Loss in the Entorhinal Cortex and Impaired LTP in Perforant Path-Granule Cell Synapses. Experimental Neurology, 176, 336-341. http://dx.doi.org/10.1006/exnr.2002.7966
|
[53]
|
Burguillos, M.A., Hajji, N., Englund, E., Persson, A., Cenci, A.M., Machado, A., Cano, J., Joseph, B. and Venero, J.L. (2011) Apoptosis-Inducing Factor Mediates Dopaminergic Cell Death in Response to LPS-Induced Inflammatory Stimulus: Evidence in Parkinson’s Disease Patients. Neurobiology of Disease, 41, 177-188.
http://dx.doi.org/10.1016/j.nbd.2010.09.005
|
[54]
|
Lee, J.W., Lee, Y.K., Yuk, D.Y., Choi, D.Y., Ban, S.B., Oh, K.W. and Hong, J.T. (2008) Neuro-Inflammation Induced by Lipopolysaccharide Causes Cognitive Impairment through Enhancement of Beta-Amyloid Generation. Journal of Neuroinflammation, 5, 37. http://dx.doi.org/10.1186/1742-2094-5-37
|
[55]
|
Richwine, A.F., Parkin, A.O., Buchanan, J.B., Chen, J., Markham, J.A., Juraska, J.M. and Johnson, R.W. (2008) Architectural Changes to CA1 Pyramidal Neurons in Adult and Aged Mice after Peripheral Immune Stimulation. Psycho- neuroendocrinology, 33, 1369-1377. http://dx.doi.org/10.1016/j.psyneuen.2008.08.003
|
[56]
|
Chugh, D., Nilsson, P., Afjei, S.A., Bakochi, A. and Ekdahl, C.T. (2013) Brain Inflammation Induces Post-Synaptic Changes during Early Synapse Formation in Adult-Born Hippocampal Neurons. Experimental Neurology, 250, 176- 188. http://dx.doi.org/10.1016/j.expneurol.2013.09.005
|
[57]
|
Jakubs, K., Bonde, S., Iosif, R.E., Ekdahl, C.T., Kokaia, Z., Kokaia, M. and Lindvall, O. (2008) Inflammation Regulates Functional Integration of Neurons Born in Adult Brain. Journal of Neuroscience, 28, 12477-12488.
http://dx.doi.org/10.1523/JNEUROSCI.3240-08.2008
|
[58]
|
Commins, S., O’Neill, L.A. and O’Mara, S.M. (2001) The Effects of the Bacterial Endotoxin Lipopolysaccharide on Synaptic Transmission and Plasticity in the CA1-Subiculum Pathway in Vivo. Neuroscience, 102, 273-280.
http://dx.doi.org/10.1016/S0306-4522(00)00498-X
|
[59]
|
Jo, J.H., Park, E.J., Lee, J.K., Jung, M.W. and Lee, C.J. (2001) Lipopolysaccharide Inhibits Induction of Long-Term Potentiation and Depression in the Rat Hippocampal CA1 Area. European Journal of Pharmacology, 422, 69-76.
http://dx.doi.org/10.1016/S0014-2999(01)01075-5
|
[60]
|
Min, S.S., Quan, H.Y., Ma, J., Lee, K.H., Back, S.K., Na, H.S., Han, S.H., Yee, J.Y., Kim, C., Han, J.S. and Seol, G.H. (2009) Impairment of Long-Term Depression Induced by Chronic Brain Inflammation in Rats. Biochemical and Biophysical Research Communications, 383, 93-97. http://dx.doi.org/10.1016/j.bbrc.2009.03.133
|
[61]
|
Gentleman, S.M., Nash, M.J., Sweeting, C.J., Graham, D.I. and Roberts, G.W. (1993) β-Amyloid Precursor Protein (βAPP) as a Marker for Axonal Injury after Head Injury. Neuroscience Letters, 160, 139-144.
http://dx.doi.org/10.1016/0304-3940(93)90398-5
|
[62]
|
Chen, X.H., Johnson, V.E., Uryu, K., Trojanowski, J.Q. and Smith, D.H. (2009) A Lack of Amyloid Beta Plaques Despite Persistent Accumulation of Amyloid β in Axons of Long-Term Survivors of Traumatic Brain Injury. Brain Pathology, 19, 214-223.
http://dx.doi.org/10.1111/j.1750-3639.2008.00176.x
|
[63]
|
Mongiat, L.A. and Schinder, A.F. (2011) Adult Neurogenesis and the Plasticity of the Dentate Gyrus Network. Euro-pean Journal of Neuroscience, 33, 1055-1061. http://dx.doi.org/10.1111/j.1460-9568.2011.07603.x
|
[64]
|
Lee, J.W., Lee, Y.K., Yuk, D.Y., Choi, D.Y., Ban, S.B., Oh, K.W. and Hong, J.T. (2008) Neuro-Inflammation Induced by Lipopolysaccharide Causes Cognitive Impairment through Enhancement of Beta-Amyloid Generation. Journal of Neuroinflammation, 5, 37. http://dx.doi.org/10.1186/1742-2094-5-37
|
[65]
|
Sheng, J.G., Bora, S.H., Xu, G., Borchelt, D.R., Price, D.L. and Koliatsos, V.E. (2003) Lipopolysaccharide-Induced- Neuroinflammation Increases Intracellular Accumulation of Amyloid Precursor Protein and Amyloid β Peptide in APPswe Transgenic Mice. Neurobiology of Disease, 14, 133-145. http://dx.doi.org/10.1016/S0969-9961(03)00069-X
|
[66]
|
Joshi, Y.B., Giannopoulos, P.F., Chu, J. and Praticò, D. (2014) Modulation of Lipopolysaccharide-Induced Memory Insult, γ-Secretase, and Neuroinflammation in Triple Transgenic Mice by 5-Lipoxygenase. Neurobiology of Aging, 35, 1024-1031. http://dx.doi.org/10.1016/j.neurobiolaging.2013.11.016
|
[67]
|
Qiao, X., Cummins, D.J. and Paul, S.M. (2001) Neuroinflammation-Induced Acceleration of Amyloid Deposition in the APPV717F Transgenic Mouse. European Journal of Neuroscience, 14, 474-482.
http://dx.doi.org/10.1046/j.0953-816x.2001.01666.x
|
[68]
|
DiCarlo, G., Wilcock, D., Henderson, D., Gordon, M. and Morgan, D. (2001) Intrahippocampal LPS Injections Reduce Aβ Load in APP+PS1 Transgenic Mice. Neurobiology of Aging, 22, 1007-1012.
http://dx.doi.org/10.1016/S0197-4580(01)00292-5
|
[69]
|
Herber, D.L., Mercer, M., Roth, L.M., Symmonds, K., Maloney, J., Wilson, N., Freeman, M.J., Morgan, D. and Gordon, M.N. (2007) Microglial Activation Is Required for Aβ Clearance after Intracranial Injection of Lipopolysaccharide in APP Transgenic Mice. Journal of Neuroimmune Pharmacology, 2, 222-231.
http://dx.doi.org/10.1007/s11481-007-9069-z
|
[70]
|
Kandalepas, P.C., Sadleir, K.R., Eimer, W.A., Zhao, J., Nicholson, D.A. and Vassar, R. (2013) The Alzheimer’s β-Secretase BACE1 Localizes to Normal Presynaptic Terminals and to Dystrophic Presynaptic Terminals Surrounding Amyloid Plaques. Acta Neuropathologica, 126, 329-352. http://dx.doi.org/10.1007/s00401-013-1152-3
|