Al-Noor, T.H., Al-Jeboori, A.T. and Aziz, M.R. (2013) Preparation, Characterization and Antimicrobial Activities of Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) Mixed Ligand Complexes Schiff Base Derived from Cephalexin Drug and 4(Dimethylamino) Benzaldehyde with Nicotinamide. Advances in Physics Theories and Applications, 18, 1-8.

has been cited by the following article:

• TITLE: Synthesis and Characterization of Schiff Base Metal Complexes Derived from Cefotaxime with 1H-indole-2,3-dione (Isatin) and 4-N,N-dimethyl-aminobenzaldehyde

  AUTHORS: Ahlam Jameel Abdulghani, Rasha Khuder Hussain

  KEYWORDS: Cefotaxime, Schiff Bases, Metal Complexes, Antibacterial Activity

  JOURNAL NAME: Open Journal of Inorganic Chemistry, Vol.5 No.4, August 31, 2015

  ABSTRACT: This work involved the synthesis of two Schiff base derivatives of cefotaxime antibiotic (CFX) namely: [sodium3-(acetoxymethyl)-7-((Z)-2-(methoxyimino)-2-(2-((E)-2–oxoindolin-3-ylide-neamino) thiazol-4-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate]. (0.5) Methanol (LI) and [sodium3-(acetoxymethyl)-7-((2Z)-2-(2-(4-dimethylamino) benzylideneamino) thiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylate]. (0.5) Methanol (LII) from the condensation reaction of the antibiotic with 1H-Indole-2,3-dione(isatin) and -N, N-dimethyl amino benzaldehyde respectively. Metal complexes of the two Schiff base ligands with Co(II), Ni(II), Cu(II), Cd(II), Pd(II) and Pt(IV) ions were prepared by reacting each ligand with the metal salts in refluxing ethanol. The chemical structures of the two ligands as well as the stereo-chemical structures and geometries of the studied metal complexes were suggested depending the results obtained from CHN and TG analysis, NMR, FTIR, and atomic absorption spectrophotometry, electronic spectra, magnetic moments and conductivity measurements. The mole ratio of the ligands to the metal ion was 1:1 with tridentate bonding behaviors of the coordinating ligands with the metal ions.